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Aliases for NAPSA Gene

Aliases for NAPSA Gene

  • Napsin A Aspartic Peptidase 2 3 5
  • Kidney-Derived Aspartic Protease-Like Protein 2 3
  • Aspartyl Protease 4 3 4
  • TA01/TA02 3 4
  • Napsin-1 3 4
  • Asp 4 3 4
  • ASP4 3 4
  • NAP1 3 4
  • NAPA 3 4
  • Pronapsin A 3
  • EC 3.4.23.- 4
  • Napsin-A 3
  • SNAPA 3
  • Kdap 3
  • KAP 3

External Ids for NAPSA Gene

Previous GeneCards Identifiers for NAPSA Gene

  • GC19M055554
  • GC19M055555
  • GC19M050861
  • GC19M047199
  • GC19M050366
  • GC19M050367
  • GC19M050368
  • GC19M050369
  • GC19M050370
  • GC19M050371
  • GC19M050373
  • GC19M050374

Summaries for NAPSA Gene

Entrez Gene Summary for NAPSA Gene

  • This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

GeneCards Summary for NAPSA Gene

NAPSA (Napsin A Aspartic Peptidase) is a Protein Coding gene. Diseases associated with NAPSA include Ovarian Clear Cell Adenofibroma and Krukenberg Carcinoma. Among its related pathways are Metabolism of proteins and Lysosome. Gene Ontology (GO) annotations related to this gene include peptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is CTSD.

UniProtKB/Swiss-Prot for NAPSA Gene

  • May be involved in processing of pneumocyte surfactant precursors.

Gene Wiki entry for NAPSA Gene

Additional gene information for NAPSA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPSA Gene

Genomics for NAPSA Gene

GeneHancer (GH) Regulatory Elements for NAPSA Gene

Promoters and enhancers for NAPSA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J050368 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.3 274 1.8 CLOCK ARNT SIN3A ZNF2 ZNF48 YY1 ARID2 ZNF207 ZNF143 FOS ENSG00000269392 NAPSA NAPSB NR1H2
GH19J050365 Promoter 0.8 EPDnew 650.7 +3.7 3672 0.1 POLR2A IKZF1 EED ZFP91 ATF7 DPF2 IKZF2 NAPSA ENSG00000269392 NAPSB NR1H2
GH19J050346 Enhancer 1.1 Ensembl ENCODE 12.8 +21.3 21302 3.9 PKNOX1 FOXA2 SMAD1 ARID4B DMAP1 IRF4 ZNF48 ZNF143 ATF7 RUNX3 NAPSB KCNC3 NAPSA POLD1 JOSD2 ASPDH EMC10 FAM71E1 KLK2 NR1H2
GH19J050479 Enhancer 1 ENCODE dbSUPER 11.8 -110.2 -110180 0.7 ELF3 HDGF PKNOX1 RB1 ARID4B SIN3A ZNF2 RAD21 ZNF48 CBX5 GC19P050481 NAPSA NR1H2 CLEC11A LOC100506114 EMC10 FAM71E1
GH19J050537 Enhancer 1.1 ENCODE dbSUPER 10.7 -168.5 -168548 0.1 SIN3A ZNF2 IRF4 ZNF48 ARID2 ZNF143 ATF7 REST ZNF592 MEF2D ASPDH JOSD2 LRRC4B GPR32 SNORD88A SNORD88B SNORD88C NAPSA NR1H2 C19orf48
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAPSA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAPSA gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • Elk-1
  • HOXA3

Genomic Locations for NAPSA Gene

Genomic Locations for NAPSA Gene
10,860 bases
Minus strand
7,354 bases
Minus strand

Genomic View for NAPSA Gene

Genes around NAPSA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPSA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPSA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPSA Gene

Proteins for NAPSA Gene

  • Protein details for NAPSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8WWD9

    Protein attributes for NAPSA Gene

    420 amino acids
    Molecular mass:
    45387 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAPSA Gene

Post-translational modifications for NAPSA Gene

  • Glycosylation at Asn336, isoforms=133, and isoforms=90
  • Modification sites at PhosphoSitePlus

Other Protein References for NAPSA Gene

Antibody Products

No data available for DME Specific Peptides for NAPSA Gene

Domains & Families for NAPSA Gene

Gene Families for NAPSA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for NAPSA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase A1 family.
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with NAPSA: view

Function for NAPSA Gene

Molecular function for NAPSA Gene

UniProtKB/Swiss-Prot Function:
May be involved in processing of pneumocyte surfactant precursors.

Enzyme Numbers (IUBMB) for NAPSA Gene

Gene Ontology (GO) - Molecular Function for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 14766755
GO:0004190 aspartic-type endopeptidase activity IEA,NAS 9877162
GO:0008233 peptidase activity IEA,TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NAPSA: view
genes like me logo Genes that share phenotypes with NAPSA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAPSA

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NAPSA Gene

Localization for NAPSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPSA Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAPSA gene
Compartment Confidence
extracellular 5
lysosome 5
endosome 4
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 18216060
GO:0005764 lysosome IDA,IEA 14766755
GO:0070062 extracellular exosome HDA 19056867
GO:0097208 alveolar lamellar body IDA 18216060
genes like me logo Genes that share ontologies with NAPSA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NAPSA Gene

Pathways & Interactions for NAPSA Gene

genes like me logo Genes that share pathways with NAPSA: view

Pathways by source for NAPSA Gene

2 Reactome pathways for NAPSA Gene
1 KEGG pathway for NAPSA Gene

Gene Ontology (GO) - Biological Process for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,NAS 9877162
GO:0006914 autophagy IBA --
GO:0030163 protein catabolic process IBA --
GO:0033619 membrane protein proteolysis IDA 14766755
GO:0043129 surfactant homeostasis IDA 18216060
genes like me logo Genes that share ontologies with NAPSA: view

No data available for SIGNOR curated interactions for NAPSA Gene

Drugs & Compounds for NAPSA Gene

(1) Drugs for NAPSA Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pepstatin A Pharma Aspartic proteinases inhibitor 0
genes like me logo Genes that share compounds with NAPSA: view

Transcripts for NAPSA Gene

mRNA/cDNA for NAPSA Gene

Unigene Clusters for NAPSA Gene

Napsin A aspartic peptidase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPSA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -

Relevant External Links for NAPSA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAPSA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAPSA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAPSA Gene

This gene is overexpressed in Lung (x39.1) and Kidney - Cortex (x9.7).

Protein differential expression in normal tissues from HIPED for NAPSA Gene

This gene is overexpressed in Urine (42.8) and Lung (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NAPSA Gene

NURSA nuclear receptor signaling pathways regulating expression of NAPSA Gene:


SOURCE GeneReport for Unigene cluster for NAPSA Gene:


mRNA Expression by UniProt/SwissProt for NAPSA Gene:

Tissue specificity: Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for NAPSA Gene

  • Lung(4.8)
  • Kidney(4.5)
  • Liver(4)
genes like me logo Genes that share expression patterns with NAPSA: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPSA Gene

Orthologs for NAPSA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPSA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAPSA 34 33
  • 99.29 (n)
(Bos Taurus)
Mammalia NAPSA 34 33
  • 85.12 (n)
(Canis familiaris)
Mammalia NAPSA 34 33
  • 84.41 (n)
(Rattus norvegicus)
Mammalia Napsa 33
  • 78.56 (n)
(Mus musculus)
Mammalia Napsa 16 34 33
  • 78.45 (n)
(Monodelphis domestica)
Mammalia NAPSA 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia NAPSA 34
  • 55 (a)
(Gallus gallus)
Aves -- 34
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
(Danio rerio)
Actinopterygii NAPSA 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta cathD 34
  • 48 (a)
CG10104 34
  • 41 (a)
(Caenorhabditis elegans)
Secernentea asp-4 34
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8194 34
  • 45 (a)
Species where no ortholog for NAPSA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAPSA Gene

Gene Tree for NAPSA (if available)
Gene Tree for NAPSA (if available)
Evolutionary constrained regions (ECRs) for NAPSA: view image

Paralogs for NAPSA Gene

Paralogs for NAPSA Gene

(7) SIMAP similar genes for NAPSA Gene using alignment to 2 proteins:

  • M0QXC5_HUMAN Pseudogenes for NAPSA Gene

genes like me logo Genes that share paralogs with NAPSA: view

Variants for NAPSA Gene

Sequence variations from dbSNP and Humsavar for NAPSA Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000184052 -- 50,360,406(-) T/C intron_variant
rs1000219894 -- 50,370,604(-) C/G upstream_transcript_variant
rs1000481143 -- 50,366,500(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001187549 -- 50,359,257(-) G/A intron_variant
rs1001782738 -- 50,370,071(-) C/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAPSA Gene

Variant ID Type Subtype PubMed ID
nsv1066389 CNV gain 25217958
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv2529 CNV insertion 18451855

Variation tolerance for NAPSA Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAPSA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPSA Gene

Disorders for NAPSA Gene

MalaCards: The human disease database

(17) MalaCards diseases for NAPSA Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian clear cell adenofibroma
krukenberg carcinoma
  • krukenberg neoplasm
ovarian clear cell carcinoma
  • clear-cell ovarian carcinoma
sarcomatoid mesothelioma
  • malignant fibrous mesothelioma
desquamative interstitial pneumonia
  • interstitial pneumonitis, desquamative, familial
- elite association - COSMIC cancer census association via MalaCards
Search NAPSA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAPSA

genes like me logo Genes that share disorders with NAPSA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAPSA Gene

Publications for NAPSA Gene

  1. Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. (PMID: 10580105) Chuman Y … Linder S (FEBS letters 1999) 3 4 22 58
  2. Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. (PMID: 19740516) Bishop JA … Illei PB (Human pathology 2010) 3 22 58
  3. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis. (PMID: 18216060) Woischnik M … Griese M (The European respiratory journal 2008) 3 22 58
  4. The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. (PMID: 18195689) Ueno T … Linder S (Laboratory investigation; a journal of technical methods and pathology 2008) 3 22 58
  5. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. (PMID: 13129928) Brasch F … Buhling F (The Journal of biological chemistry 2003) 3 22 58

Products for NAPSA Gene

Sources for NAPSA Gene

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