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Aliases for FHL5 Gene

Aliases for FHL5 Gene

  • Four And A Half LIM Domains 5 2 3 5
  • Activator Of CAMP-Responsive Element Modulator In Testis 3 4
  • FHL-5 3 4
  • ACT 3 4
  • Activator Of CAMP-Responsive Element Modulator (CREM) In Testis 3
  • Four And A Half LIM Domains Protein 5 3
  • Activator Of CREM In Testis 4
  • LIM Protein ACT 3
  • 1700027G07Rik 3
  • DJ393D12.2 3

External Ids for FHL5 Gene

Previous GeneCards Identifiers for FHL5 Gene

  • GC06P097056
  • GC06P097117
  • GC06P094444

Summaries for FHL5 Gene

Entrez Gene Summary for FHL5 Gene

  • The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]

GeneCards Summary for FHL5 Gene

FHL5 (Four And A Half LIM Domains 5) is a Protein Coding gene. Among its related pathways are Transcription_CREM signaling in testis. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is FHL2.

UniProtKB/Swiss-Prot for FHL5 Gene

  • May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.

Gene Wiki entry for FHL5 Gene

Additional gene information for FHL5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL5 Gene

Genomics for FHL5 Gene

GeneHancer (GH) Regulatory Elements for FHL5 Gene

Promoters and enhancers for FHL5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J096562 Promoter 0.6 EPDnew 650.7 +0.0 7 0.1 CREB1 FHL5 GC06M096651
GH06J096563 Promoter 0.5 EPDnew 650.7 +0.6 561 0.1 FHL5 GC06M096651
GH06J096014 Promoter/Enhancer 1.1 EPDnew ENCODE 5.6 -546.7 -546706 1.8 GTF2F1 ZNF202 CTCF MXI1 E2F1 MTA1 POLR2A TARDBP ZNF444 PRDM10 FUT9 MANEA-DT FHL5 KRT18P50
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FHL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FHL5 gene promoter:
  • Pax-3
  • Nkx2-5
  • RORalpha1
  • STAT5A
  • IRF-7A
  • Evi-1
  • LCR-F1
  • STAT5B

Genomic Locations for FHL5 Gene

Genomic Locations for FHL5 Gene
56,073 bases
Plus strand
54,089 bases
Plus strand

Genomic View for FHL5 Gene

Genes around FHL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHL5 Gene

Proteins for FHL5 Gene

  • Protein details for FHL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Four and a half LIM domains protein 5
    Protein Accession:
    Secondary Accessions:
    • B2RBD1
    • E1P526
    • Q5TD98
    • Q8WW21
    • Q9NQU2

    Protein attributes for FHL5 Gene

    284 amino acids
    Molecular mass:
    32720 Da
    Quaternary structure:
    • Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.

    Three dimensional structures from OCA and Proteopedia for FHL5 Gene

neXtProt entry for FHL5 Gene

Post-translational modifications for FHL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FHL5 Gene

Antibody Products

  • Abcam antibodies for FHL5
  • Boster Bio Antibodies for FHL5
  • Santa Cruz Biotechnology (SCBT) Antibodies for FHL5

No data available for DME Specific Peptides for FHL5 Gene

Domains & Families for FHL5 Gene

Gene Families for FHL5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FHL5 Gene

Suggested Antigen Peptide Sequences for FHL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FHL5: view

No data available for UniProtKB/Swiss-Prot for FHL5 Gene

Function for FHL5 Gene

Molecular function for FHL5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.

Phenotypes From GWAS Catalog for FHL5 Gene

Gene Ontology (GO) - Molecular Function for FHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IBA --
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FHL5: view
genes like me logo Genes that share phenotypes with FHL5: view

Animal Models for FHL5 Gene

MGI Knock Outs for FHL5:
  • Fhl5 Fhl5<tm1Saco>

Animal Model Products

miRNA for FHL5 Gene

miRTarBase miRNAs that target FHL5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FHL5 Gene

Localization for FHL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FHL5 Gene

Nucleus. Note=Nuclei of round and elongated spermatids.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FHL5 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for FHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0030018 Z disc IBA --
genes like me logo Genes that share ontologies with FHL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FHL5 Gene

Pathways & Interactions for FHL5 Gene

genes like me logo Genes that share pathways with FHL5: view

Pathways by source for FHL5 Gene

1 GeneGo (Thomson Reuters) pathway for FHL5 Gene

Gene Ontology (GO) - Biological Process for FHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with FHL5: view

No data available for SIGNOR curated interactions for FHL5 Gene

Drugs & Compounds for FHL5 Gene

No Compound Related Data Available

Transcripts for FHL5 Gene

mRNA/cDNA for FHL5 Gene

Unigene Clusters for FHL5 Gene

Four and a half LIM domains 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHL5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: -

Relevant External Links for FHL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FHL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FHL5 Gene

mRNA differential expression in normal tissues according to GTEx for FHL5 Gene

This gene is overexpressed in Artery - Tibial (x19.7) and Artery - Coronary (x5.6).

Protein differential expression in normal tissues from HIPED for FHL5 Gene

This gene is overexpressed in Gallbladder (19.2), Testis (17.5), and Plasma (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FHL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FHL5 Gene:


SOURCE GeneReport for Unigene cluster for FHL5 Gene:


mRNA Expression by UniProt/SwissProt for FHL5 Gene:

Tissue specificity: Testis-specific (at protein level).
genes like me logo Genes that share expression patterns with FHL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FHL5 Gene

Orthologs for FHL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FHL5 34 33
  • 99.18 (n)
(Canis familiaris)
Mammalia FHL5 34 33
  • 90.73 (n)
(Bos Taurus)
Mammalia FHL5 34 33
  • 90.61 (n)
(Mus musculus)
Mammalia Fhl5 16 34 33
  • 86.34 (n)
(Rattus norvegicus)
Mammalia Fhl5 33
  • 86.03 (n)
(Monodelphis domestica)
Mammalia FHL5 34
  • 60 (a)
(Gallus gallus)
Aves FHL5 34 33
  • 73 (n)
(Anolis carolinensis)
Reptilia FHL5 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fhl5 33
  • 67.14 (n)
Str.13651 33
(Danio rerio)
Actinopterygii fhl5 34
  • 61 (a)
(Caenorhabditis elegans)
Secernentea lim-9 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for FHL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FHL5 Gene

Gene Tree for FHL5 (if available)
Gene Tree for FHL5 (if available)
Evolutionary constrained regions (ECRs) for FHL5: view image

Paralogs for FHL5 Gene

(4) SIMAP similar genes for FHL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FHL5: view

Variants for FHL5 Gene

Sequence variations from dbSNP and Humsavar for FHL5 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000030124 -- 96,598,063(+) T/C intron_variant
rs1000036928 -- 96,562,659(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000038772 -- 96,577,475(+) C/G intron_variant
rs1000044067 -- 96,591,104(+) G/A intron_variant
rs1000096227 -- 96,561,445(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FHL5 Gene

Variant ID Type Subtype PubMed ID
esv3439889 CNV insertion 20981092
nsv507350 OTHER sequence alteration 20534489

Variation tolerance for FHL5 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.06; 98.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FHL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHL5 Gene

Disorders for FHL5 Gene

Additional Disease Information for FHL5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FHL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FHL5 Gene

Publications for FHL5 Gene

  1. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. (PMID: 22319020) Davies RW … McPherson R (Circulation. Cardiovascular genetics 2012) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston KI … Carrell DT (Human reproduction (Oxford, England) 2010) 3 44 58
  4. A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD. (PMID: 17368652) Belbin O … Morgan K (Neurobiology of aging 2008) 3 44 58
  5. Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males. (PMID: 16687568) Christensen GL … Carrell DT (Molecular human reproduction 2006) 3 44 58

Products for FHL5 Gene

Sources for FHL5 Gene

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