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Aliases for GSTO1 Gene

Aliases for GSTO1 Gene

  • Glutathione S-Transferase Omega 1 2 3 5
  • Glutathione-Dependent Dehydroascorbate Reductase 3 4
  • Glutathione S-Transferase Omega 1-1 3 4
  • S-(Phenacyl)Glutathione Reductase 3 4
  • Monomethylarsonic Acid Reductase 3 4
  • MMA(V) Reductase 3 4
  • EC 2.5.1.18 4 56
  • GSTO 1-1 3 4
  • GSTTLp28 3 4
  • SPG-R 3 4
  • Epididymis Secretory Protein Li 21 3
  • Glutathione S-Transferase Omega-1 3
  • Glutathione-S-Transferase Like 3
  • EC 1.20.4.2 4
  • EC 1.8.5.1 4
  • HEL-S-21 3
  • GSTO-1 4
  • P28 3

External Ids for GSTO1 Gene

Previous GeneCards Identifiers for GSTO1 Gene

  • GC10P106145
  • GC10P105679
  • GC10P106004
  • GC10P099645

Summaries for GSTO1 Gene

Entrez Gene Summary for GSTO1 Gene

  • The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for GSTO1 Gene

GSTO1 (Glutathione S-Transferase Omega 1) is a Protein Coding gene. Diseases associated with GSTO1 include Proliferative Type Fibrocystic Change Of Breast and Intracystic Papillary Adenoma. Among its related pathways are Cytochrome P450 - arranged by substrate type and ascorbate recycling (cytosolic). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.

UniProtKB/Swiss-Prot for GSTO1 Gene

  • Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Gene Wiki entry for GSTO1 Gene

Additional gene information for GSTO1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTO1 Gene

Genomics for GSTO1 Gene

GeneHancer (GH) Regulatory Elements for GSTO1 Gene

Promoters and enhancers for GSTO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I104249 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 566.7 +18.4 18361 7.6 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GSTO1 GSTO2 ENSG00000260461 PDCD11 CFAP58 CFAP58-AS1 GC10M104249 MIR4482
GH10I104258 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.9 +25.1 25056 3 TEAD4 TAL1 JUN FOSL1 TCF12 POLR2A NCOR1 CBFA2T2 FOS TRIM24 GSTO2 GSTO1 MIR609 SFR1 SLK CFAP58 ITPRIP GC10M104249 MIR4482
GH10I104267 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 16.6 +33.2 33173 2.8 HDGF PKNOX1 SIN3A ZNF2 BRCA1 ETS1 ZNF207 ZNF143 FOS RUNX3 GSTO2 MIR4482 PDCD11 TAF5 GSTO1 PCGF6 CFAP58 CFAP58-AS1 GC10P104302
GH10I104274 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 16.5 +39.8 39804 1.7 CLOCK MZF1 SIN3A KLF5 RAD21 YY1 ZNF335 ZNF121 GLIS2 ZNF143 GSTO2 GSTO1 ENSG00000260461 PDCD11 CFAP58 CFAP58-AS1 GC10P104302
GH10I104316 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 +93.4 93415 24.8 FEZF1 YY1 ZNF213 ZNF143 ZNF548 SP3 MEF2D ZNF610 GLIS1 NBN ITPRIP GSTO2 PDCD11 CFAP58 SFR1 CFAP58-AS1 PCGF6 TAF5 ENSG00000260461 GSTO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GSTO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GSTO1 gene promoter:

Genomic Locations for GSTO1 Gene

Genomic Locations for GSTO1 Gene
chr10:104,235,356-104,267,464
(GRCh38/hg38)
Size:
32,109 bases
Orientation:
Plus strand
chr10:105,995,114-106,027,222
(GRCh37/hg19)

Genomic View for GSTO1 Gene

Genes around GSTO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTO1 Gene

Proteins for GSTO1 Gene

  • Protein details for GSTO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78417-GSTO1_HUMAN
    Recommended name:
    Glutathione S-transferase omega-1
    Protein Accession:
    P78417
    Secondary Accessions:
    • D3DRA3
    • F5H7H0
    • Q5TA03
    • Q7Z3T2

    Protein attributes for GSTO1 Gene

    Size:
    241 amino acids
    Molecular mass:
    27566 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAD97673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GSTO1 Gene

    Alternative splice isoforms for GSTO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTO1 Gene

Selected DME Specific Peptides for GSTO1 Gene

P78417:
  • WPWFERL
  • PVLENSQ
  • PPGPVPEG
  • YSMRFCP

Post-translational modifications for GSTO1 Gene

  • Ubiquitination at posLast=1111
  • Modification sites at PhosphoSitePlus

Other Protein References for GSTO1 Gene

Domains & Families for GSTO1 Gene

Gene Families for GSTO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GSTO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78417

UniProtKB/Swiss-Prot:

GSTO1_HUMAN :
  • Belongs to the GST superfamily. Omega family.
Family:
  • Belongs to the GST superfamily. Omega family.
genes like me logo Genes that share domains with GSTO1: view

Function for GSTO1 Gene

Molecular function for GSTO1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:11511179, ECO:0000269 PubMed:17226937};
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
UniProtKB/Swiss-Prot CatalyticActivity:
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.
UniProtKB/Swiss-Prot Function:
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Enzyme Numbers (IUBMB) for GSTO1 Gene

Phenotypes From GWAS Catalog for GSTO1 Gene

Gene Ontology (GO) - Molecular Function for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0005515 protein binding IPI 25277244
GO:0016491 oxidoreductase activity IEA,IDA 11511179
GO:0016740 transferase activity IEA --
GO:0045174 glutathione dehydrogenase (ascorbate) activity IEA,IDA 11511179
genes like me logo Genes that share ontologies with GSTO1: view
genes like me logo Genes that share phenotypes with GSTO1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTO1

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTO1 Gene

Localization for GSTO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTO1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTO1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11511179
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with GSTO1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GSTO1 Gene

Pathways & Interactions for GSTO1 Gene

genes like me logo Genes that share pathways with GSTO1: view

Gene Ontology (GO) - Biological Process for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IBA --
GO:0008152 metabolic process IEA --
GO:0009407 toxin catabolic process IBA --
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA 11035031
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC 11035031
genes like me logo Genes that share ontologies with GSTO1: view

No data available for SIGNOR curated interactions for GSTO1 Gene

Drugs & Compounds for GSTO1 Gene

(11) Drugs for GSTO1 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Vitamin E Approved, Vet_approved Nutra Enzyme, inhibitor 434,438
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0
Vitamin C Approved Nutra 581,581

(47) Additional Compounds for GSTO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(2) ApexBio Compounds for GSTO1 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with GSTO1: view

Drug Products

Transcripts for GSTO1 Gene

Unigene Clusters for GSTO1 Gene

Glutathione S-transferase omega 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTO1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - -
SP7: - -

Relevant External Links for GSTO1 Gene

GeneLoc Exon Structure for
GSTO1
ECgene alternative splicing isoforms for
GSTO1

Expression for GSTO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTO1 Gene

Protein differential expression in normal tissues from HIPED for GSTO1 Gene

This gene is overexpressed in Liver, secretome (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSTO1 Gene



Protein tissue co-expression partners for GSTO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTO1 Gene:

GSTO1

SOURCE GeneReport for Unigene cluster for GSTO1 Gene:

Hs.190028

mRNA Expression by UniProt/SwissProt for GSTO1 Gene:

P78417-GSTO1_HUMAN
Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.

Evidence on tissue expression from TISSUES for GSTO1 Gene

  • Liver(4.6)
  • Eye(4.2)
  • Skin(3.9)
  • Nervous system(3.8)
  • Lung(3.6)
  • Muscle(2.8)
  • Heart(2.7)
  • Kidney(2.4)
  • Blood(2.3)
  • Bone marrow(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with GSTO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTO1 Gene

Orthologs for GSTO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GSTO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTO1 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia GSTO1 34 33
  • 86.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GSTO1 33
  • 85.48 (n)
-- 34
  • 83 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gsto1 33
  • 80.08 (n)
mouse
(Mus musculus)
Mammalia Gsto1 33 16 34
  • 76.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GSTO1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves GSTO1 34 33
  • 66.95 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1986 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24164 33
zebrafish
(Danio rerio)
Actinopterygii gsto1 34 33
  • 62.71 (n)
ManyToMany
gsto2 34
  • 56 (a)
ManyToMany
Dr.16014 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11014 33
fruit fly
(Drosophila melanogaster)
Insecta se 33 34
  • 52.61 (n)
CG6776 34
  • 35 (a)
ManyToMany
CG6662 34
  • 31 (a)
ManyToMany
CG6673 34
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GSTO1 33
  • 48.27 (n)
worm
(Caenorhabditis elegans)
Secernentea gst-44 33 34
  • 48.38 (n)
gsto-2 34
  • 33 (a)
ManyToMany
C02D5.4 34
  • 33 (a)
ManyToMany
gsto-1 34
  • 32 (a)
ManyToMany
gsto-3 34
  • 24 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00549 33
  • 48.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3044 34
  • 35 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
Species where no ortholog for GSTO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTO1 Gene

ENSEMBL:
Gene Tree for GSTO1 (if available)
TreeFam:
Gene Tree for GSTO1 (if available)

Paralogs for GSTO1 Gene

Paralogs for GSTO1 Gene

(1) SIMAP similar genes for GSTO1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GSTO1 Gene

genes like me logo Genes that share paralogs with GSTO1: view

Variants for GSTO1 Gene

Sequence variations from dbSNP and Humsavar for GSTO1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000117213 -- 104,256,127(+) C/A intron_variant
rs1000490830 -- 104,255,806(+) G/T intron_variant
rs1000711862 -- 104,258,798(+) C/G/T intron_variant
rs1000825968 -- 104,265,893(+) T/G intron_variant
rs1000997548 -- 104,264,667(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GSTO1 Gene

Variant ID Type Subtype PubMed ID
nsv1039166 CNV loss 25217958
nsv552062 CNV loss 21841781
nsv831971 CNV gain 17160897

Variation tolerance for GSTO1 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.70; 86.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTO1 Gene

Human Gene Mutation Database (HGMD)
GSTO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTO1 Gene

Disorders for GSTO1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for GSTO1 Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
proliferative type fibrocystic change of breast
  • fibrocystic change, proliferative type with atypia
intracystic papillary adenoma
  • intracystic papilloma
cavernous sinus meningioma
  • meningioma of the cavernous sinus
patella, chondromalacia of
  • chondromalacia patellae
facial neuralgia
- elite association - COSMIC cancer census association via MalaCards
Search GSTO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSTO1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GSTO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTO1 Gene

Publications for GSTO1 Gene

  1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread AK … Board PG (Pharmacogenetics 2003) 2 3 4 22 58
  2. No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PMID: 19859803) Andonova IE … Brauch H (Breast cancer research and treatment 2010) 3 22 44 58
  3. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 22 44 58
  4. Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia. (PMID: 18941778) Pongstaporn W … Petmitr S (Journal of cancer research and clinical oncology 2009) 3 22 44 58
  5. Diversity of glutathione s-transferase omega 1 (a140d) and 2 (n142d) gene polymorphisms in worldwide populations. (PMID: 18986335) Takeshita H … Kunito T (Clinical and experimental pharmacology & physiology 2009) 3 22 44 58

Products for GSTO1 Gene

Sources for GSTO1 Gene

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