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Aliases for TP53INP1 Gene

Aliases for TP53INP1 Gene

  • Tumor Protein P53 Inducible Nuclear Protein 1 2 3 5
  • P53DINP1 3 4 4
  • P53-Dependent Damage-Inducible Nuclear Protein 1 3 4
  • Stress-Induced Protein 3 4
  • SIP 3 4
  • Tumor Protein P53-Inducible Nuclear Protein 1 3
  • P53-Inducible P53DINP1 3
  • TP53DINP1 3
  • TP53INP1A 3
  • TP53INP1B 3
  • Teap 3

External Ids for TP53INP1 Gene

Previous GeneCards Identifiers for TP53INP1 Gene

  • GC08M094561
  • GC08M095909
  • GC08M095606
  • GC08M095894
  • GC08M096007
  • GC08M091146
  • GC08M095938

Summaries for TP53INP1 Gene

GeneCards Summary for TP53INP1 Gene

TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include antioxidant activity. An important paralog of this gene is TP53INP2.

UniProtKB/Swiss-Prot for TP53INP1 Gene

  • Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Gene Wiki entry for TP53INP1 Gene

Additional gene information for TP53INP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53INP1 Gene

Genomics for TP53INP1 Gene

GeneHancer (GH) Regulatory Elements for TP53INP1 Gene

Promoters and enhancers for TP53INP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J094946 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 659.8 +0.1 107 4.7 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 TP53INP1 ENSG00000253878 NDUFAF6 C8orf37 CCNE2
GH08J094822 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.2 +125.7 125734 2.6 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B INTS8 TP53INP1 CCNE2 ENSG00000254307 ENSG00000253878 ESRP1 NDUFAF6 ENSG00000272509
GH08J095132 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.4 -189.0 -189047 12.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A ZBTB7B IRF4 PLEKHF2 VIRMA INTS8 TP53INP1 ENSG00000254248 RNU6-1209P ENSG00000253878 MIR3150BHG GC08P095140
GH08J095024 Promoter/Enhancer 1.6 Ensembl ENCODE 18 -75.8 -75771 2.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 VIRMA INTS8 TP53INP1 MIR3150BHG ENSG00000253878 CCNE2 RNU6-1209P ENSG00000254307 GC08P094978 NDUFAF6
GH08J094904 Enhancer 1.1 Ensembl ENCODE 19 +43.1 43141 3.6 HDGF FOXA2 ARNT ARID4B YBX1 YY1 ZNF143 ATF7 RUNX3 KDM4B INTS8 VIRMA TP53INP1 ENSG00000253878 NDUFAF6 CCNE2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TP53INP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TP53INP1 gene promoter:
  • p53
  • Nkx2-5
  • GATA-6
  • USF1
  • AML1a
  • USF2
  • USF-1:USF-2
  • USF-1
  • C/EBPbeta
  • AREB6

Genomic Locations for TP53INP1 Gene

Genomic Locations for TP53INP1 Gene
chr8:94,925,972-94,949,411
(GRCh38/hg38)
Size:
23,440 bases
Orientation:
Minus strand
chr8:95,938,200-95,961,639
(GRCh37/hg19)
Size:
23,440 bases
Orientation:
Minus strand

Genomic View for TP53INP1 Gene

Genes around TP53INP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53INP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53INP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53INP1 Gene

Proteins for TP53INP1 Gene

  • Protein details for TP53INP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A56-T53I1_HUMAN
    Recommended name:
    Tumor protein p53-inducible nuclear protein 1
    Protein Accession:
    Q96A56
    Secondary Accessions:
    • B2RCE5
    • Q969R9

    Protein attributes for TP53INP1 Gene

    Size:
    240 amino acids
    Molecular mass:
    27366 Da
    Quaternary structure:
    • Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B AND MAP1LC3C.

    Alternative splice isoforms for TP53INP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53INP1 Gene

Post-translational modifications for TP53INP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TP53INP1 Gene

No data available for DME Specific Peptides for TP53INP1 Gene

Domains & Families for TP53INP1 Gene

Gene Families for TP53INP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TP53INP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TP53INP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A56

UniProtKB/Swiss-Prot:

T53I1_HUMAN :
  • The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.
Domain:
  • The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.
genes like me logo Genes that share domains with TP53INP1: view

Function for TP53INP1 Gene

Molecular function for TP53INP1 Gene

UniProtKB/Swiss-Prot Function:
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
UniProtKB/Swiss-Prot Induction:
By adriamycin, gamma irradiation and H(2)O(2), in a p53/TP53-dependent way. At lower levels by UV irradiation. By TP73.

Phenotypes From GWAS Catalog for TP53INP1 Gene

Gene Ontology (GO) - Molecular Function for TP53INP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22421968
GO:0016209 antioxidant activity ISS --
genes like me logo Genes that share ontologies with TP53INP1: view
genes like me logo Genes that share phenotypes with TP53INP1: view

Animal Models for TP53INP1 Gene

MGI Knock Outs for TP53INP1:

Animal Model Products

CRISPR Products

miRNA for TP53INP1 Gene

miRTarBase miRNAs that target TP53INP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TP53INP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TP53INP1 Gene

Localization for TP53INP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53INP1 Gene

Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53INP1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TP53INP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22470510
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005776 autophagosome IEA,IDA 22421968
GO:0005829 cytosol IDA,IEA 22470510
genes like me logo Genes that share ontologies with TP53INP1: view

Pathways & Interactions for TP53INP1 Gene

genes like me logo Genes that share pathways with TP53INP1: view

Pathways by source for TP53INP1 Gene

SIGNOR curated interactions for TP53INP1 Gene

Gene Ontology (GO) - Biological Process for TP53INP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TP53INP1: view

Drugs & Compounds for TP53INP1 Gene

No Compound Related Data Available

Transcripts for TP53INP1 Gene

mRNA/cDNA for TP53INP1 Gene

Unigene Clusters for TP53INP1 Gene

Tumor protein p53 inducible nuclear protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TP53INP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53INP1 Gene

No ASD Table

Relevant External Links for TP53INP1 Gene

GeneLoc Exon Structure for
TP53INP1
ECgene alternative splicing isoforms for
TP53INP1

Expression for TP53INP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP53INP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53INP1 Gene

This gene is overexpressed in Liver (x5.2) and Pancreas (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TP53INP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TP53INP1 Gene:

TP53INP1

SOURCE GeneReport for Unigene cluster for TP53INP1 Gene:

Hs.492261

mRNA Expression by UniProt/SwissProt for TP53INP1 Gene:

Q96A56-T53I1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for TP53INP1 Gene

  • Lung(4.3)
  • Liver(2.7)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with TP53INP1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53INP1 Gene

Orthologs for TP53INP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53INP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53INP1 34 33
  • 99.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TP53INP1 34 33
  • 90.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TP53INP1 34 33
  • 89.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trp53inp1 16 34 33
  • 87.59 (n)
rat
(Rattus norvegicus)
Mammalia Tp53inp1 33
  • 86.75 (n)
oppossum
(Monodelphis domestica)
Mammalia TP53INP1 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TP53INP1 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TP53INP1 34 33
  • 74.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TP53INP1 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tp53inp1 33
  • 61.68 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3480 33
zebrafish
(Danio rerio)
Actinopterygii tp53inp1 34 33
  • 58.44 (n)
OneToOne
wufb70a09 33
fruit fly
(Drosophila melanogaster)
Insecta DOR 34
  • 14 (a)
OneToMany
Species where no ortholog for TP53INP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TP53INP1 Gene

ENSEMBL:
Gene Tree for TP53INP1 (if available)
TreeFam:
Gene Tree for TP53INP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TP53INP1: view image

Paralogs for TP53INP1 Gene

Paralogs for TP53INP1 Gene

(1) SIMAP similar genes for TP53INP1 Gene using alignment to 2 proteins:

  • T53I1_HUMAN
  • C9JAL6_HUMAN
genes like me logo Genes that share paralogs with TP53INP1: view

Variants for TP53INP1 Gene

Sequence variations from dbSNP and Humsavar for TP53INP1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000127895 -- 94,928,716(-) G/A 3_prime_UTR_variant
rs1000180584 -- 94,929,068(-) T/C 3_prime_UTR_variant
rs1000232876 -- 94,941,317(-) AAA/A intron_variant
rs1000410030 -- 94,935,731(-) A/G intron_variant
rs1000465371 -- 94,942,225(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TP53INP1 Gene

Variant ID Type Subtype PubMed ID
nsv1144230 CNV deletion 24896259
nsv508520 CNV deletion 20534489

Variation tolerance for TP53INP1 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TP53INP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP53INP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53INP1 Gene

Disorders for TP53INP1 Gene

Additional Disease Information for TP53INP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TP53INP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP53INP1 Gene

Publications for TP53INP1 Gene

  1. p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. (PMID: 11511362) Okamura S … Nakamura Y (Molecular cell 2001) 2 3 4 22 58
  2. Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization. (PMID: 12438758) Nowak J … Pébusque MJ (Cytogenetic and genome research 2002) 2 3 22 58
  3. TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death. (PMID: 22421968) Seillier M … Dusetti NJ (Cell death and differentiation 2012) 3 4 58
  4. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. (PMID: 22470510) Sancho A … Zorzano A (PloS one 2012) 3 4 58
  5. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PMID: 20581827) Voight BF … GIANT Consortium (Nature genetics 2010) 3 44 58

Products for TP53INP1 Gene

Sources for TP53INP1 Gene

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