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Aliases for CD86 Gene

Aliases for CD86 Gene

  • CD86 Molecule 2 3 5
  • CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen) 2 3
  • CTLA-4 Counter-Receptor B7.2 3 4
  • CD28LG2 3 4
  • FUN-1 3 4
  • BU63 3 4
  • B70 3 4
  • B-Lymphocyte Activation Antigen B7-2 3
  • T-Lymphocyte Activation Antigen CD86 3
  • B-Lymphocyte Antigen B7-2 2
  • Activation B7-2 Antigen 4
  • CD86 Antigen 4
  • LAB72 3
  • B7-2 3
  • B7.2 3

External Ids for CD86 Gene

Previous HGNC Symbols for CD86 Gene

  • CD28LG2

Previous GeneCards Identifiers for CD86 Gene

  • GC03P118451
  • GC03P121633
  • GC03P123055
  • GC03P123095
  • GC03P123256
  • GC03P121774
  • GC03P119148

Summaries for CD86 Gene

Entrez Gene Summary for CD86 Gene

  • This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

GeneCards Summary for CD86 Gene

CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Gallbladder Squamous Cell Carcinoma and Myocarditis. Among its related pathways are Cytokine Signaling in Immune system and Th2 Differentiation Pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and coreceptor activity. An important paralog of this gene is CD80.

UniProtKB/Swiss-Prot for CD86 Gene

  • Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

  • (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Wiki entry for CD86 Gene

Additional gene information for CD86 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD86 Gene

Genomics for CD86 Gene

GeneHancer (GH) Regulatory Elements for CD86 Gene

Promoters and enhancers for CD86 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I122073 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562.7 +22.1 22068 7.1 HDGF PKNOX1 FOXA2 BMI1 BATF IRF4 ZNF143 ATF7 ETV6 BCLAF1 CD86 ENSG00000202388 DTX3L PARP9 CCDC58 FAM162A IQCB1 EAF2 CSTA HCLS1
GH03I122054 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 205 1.5 BATF IRF4 RELA POLR2A ATF7 ETV6 BCLAF1 IKZF2 RUNX3 ZNF687 CD86 ENSG00000202388 ILDR1
GH03I122002 Enhancer 1.3 FANTOM5 Ensembl ENCODE 13.9 -51.3 -51299 2.9 BMI1 BATF KLF5 IRF4 EGR1 ZNF207 ATF7 ETV6 BCLAF1 IKZF2 IQCB1 SLC15A2 CD86 ENSG00000202388 ILDR1 CSTA EAF2 HCLS1 LOC101927010 GC03M121324
GH03I121997 Enhancer 1.3 FANTOM5 Ensembl ENCODE 13.5 -56.9 -56861 2.2 ZBTB21 JUN EBF1 BMI1 BATF IRF4 RELA FOSL1 ZFHX2 POLR2A SLC15A2 CD86 EAF2 ENSG00000202388 ILDR1 IQCB1 CSTA HCLS1 LOC101927010 GC03M121324
GH03I122056 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +3.2 3184 4.3 NR2F1 JUNB ATF2 RELA BCL11A TARDBP IKZF1 NR2C1 MLLT1 RUNX3 ILDR1 ENSG00000202388 CD86 IQCB1 HCLS1 EAF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD86 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD86 gene promoter:

Genomic Locations for CD86 Gene

Genomic Locations for CD86 Gene
chr3:122,055,362-122,121,143
(GRCh38/hg38)
Size:
65,782 bases
Orientation:
Plus strand
chr3:121,774,209-121,839,990
(GRCh37/hg19)

Genomic View for CD86 Gene

Genes around CD86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD86 Gene

Proteins for CD86 Gene

  • Protein details for CD86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42081-CD86_HUMAN
    Recommended name:
    T-lymphocyte activation antigen CD86
    Protein Accession:
    P42081
    Secondary Accessions:
    • A0N0P0
    • B7Z2F3
    • B7Z702
    • E7ETN5
    • E9PC27
    • Q13655
    • Q6FHB1
    • Q6GTS4
    • Q7M4L5

    Protein attributes for CD86 Gene

    Size:
    329 amino acids
    Molecular mass:
    37682 Da
    Quaternary structure:
    • Homodimer. Interacts with MARCH8.
    • (Microbial infection) Interacts with adenovirus subgroup b fiber protein.

    Three dimensional structures from OCA and Proteopedia for CD86 Gene

    Alternative splice isoforms for CD86 Gene

neXtProt entry for CD86 Gene

Post-translational modifications for CD86 Gene

  • Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
  • Glycosylation at Asn33, Asn47, posLast=135135, posLast=146146, Asn154, posLast=177177, posLast=192192, and Asn213
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CD86

No data available for DME Specific Peptides for CD86 Gene

Domains & Families for CD86 Gene

Gene Families for CD86 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD86 Gene

Suggested Antigen Peptide Sequences for CD86 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD86: view

No data available for UniProtKB/Swiss-Prot for CD86 Gene

Function for CD86 Gene

Molecular function for CD86 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD86,80kDa,identified by monoclonal antibody FUN1,B7.2 expressed on monocytes,dendritic cells and activated B,T and natural killer cells (antigen presenting cells)
UniProtKB/Swiss-Prot Function:
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for adenovirus subgroup B.

Phenotypes From GWAS Catalog for CD86 Gene

Gene Ontology (GO) - Molecular Function for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity TAS 7694363
GO:0005515 protein binding IPI 9915850
GO:0015026 coreceptor activity NAS 9915850
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS --
genes like me logo Genes that share ontologies with CD86: view
genes like me logo Genes that share phenotypes with CD86: view

Animal Models for CD86 Gene

MGI Knock Outs for CD86:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD86 Gene

Localization for CD86 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD86 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD86 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
nucleus 2
cytosol 2
lysosome 2
endosome 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS,TAS --
GO:0009986 cell surface HDA,IDA 23981064
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 15908444
genes like me logo Genes that share ontologies with CD86: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD86 Gene

Pathways & Interactions for CD86 Gene

genes like me logo Genes that share pathways with CD86: view

Gene Ontology (GO) - Biological Process for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006955 immune response TAS 7694363
GO:0007165 signal transduction IEA --
GO:0007267 cell-cell signaling IC --
genes like me logo Genes that share ontologies with CD86: view

No data available for SIGNOR curated interactions for CD86 Gene

Drugs & Compounds for CD86 Gene

(18) Drugs for CD86 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abatacept Approved Pharma Target, antagonist, binder 210
Belatacept Approved, Investigational Pharma Target, inhibitor 0
Antithymocyte immunoglobulin (rabbit) Approved Pharma Target 0
antithymocyte globulin Pharma binder 0
ASP2408 Pharma 0

(10) Additional Compounds for CD86 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD86: view

Transcripts for CD86 Gene

Unigene Clusters for CD86 Gene

CD86 molecule:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD86 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - - - - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for CD86 Gene

GeneLoc Exon Structure for
CD86
ECgene alternative splicing isoforms for
CD86

Expression for CD86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD86 Gene

mRNA differential expression in normal tissues according to GTEx for CD86 Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for CD86 Gene

This gene is overexpressed in Heart (31.5), Monocytes (26.3), and Retina (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD86 Gene



Protein tissue co-expression partners for CD86 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD86 Gene:

CD86

SOURCE GeneReport for Unigene cluster for CD86 Gene:

Hs.171182

mRNA Expression by UniProt/SwissProt for CD86 Gene:

P42081-CD86_HUMAN
Tissue specificity: Expressed by activated B-lymphocytes and monocytes.

Evidence on tissue expression from TISSUES for CD86 Gene

  • Nervous system(4.4)
  • Lymph node(4.1)
  • Spleen(4.1)
  • Blood(3.8)
  • Bone marrow(3)
  • Intestine(2.8)
  • Lung(2.7)
  • Skin(2.6)
  • Liver(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CD86: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD86 Gene

Orthologs for CD86 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD86 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD86 33 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia CD86 33 34
  • 78.84 (n)
cow
(Bos Taurus)
Mammalia CD86 33 34
  • 74.38 (n)
rat
(Rattus norvegicus)
Mammalia Cd86 33
  • 68.86 (n)
mouse
(Mus musculus)
Mammalia Cd86 33 16 34
  • 68.37 (n)
oppossum
(Monodelphis domestica)
Mammalia CD86 34
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD86 34
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD86 33 34
  • 51.17 (n)
Species where no ortholog for CD86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD86 Gene

ENSEMBL:
Gene Tree for CD86 (if available)
TreeFam:
Gene Tree for CD86 (if available)

Paralogs for CD86 Gene

Paralogs for CD86 Gene

genes like me logo Genes that share paralogs with CD86: view

Variants for CD86 Gene

Sequence variations from dbSNP and Humsavar for CD86 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000050127 -- 122,118,948(+) C/T intron_variant
rs1000050980 -- 122,071,952(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000162711 -- 122,091,831(+) G/A intron_variant
rs1000219103 -- 122,057,809(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000231377 -- 122,061,269(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD86 Gene

Variant ID Type Subtype PubMed ID
esv1959984 CNV deletion 18987734
esv2500835 CNV deletion 19546169
esv33139 CNV loss 17666407
nsv3972 CNV insertion 18451855
nsv528646 CNV loss 19592680

Variation tolerance for CD86 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD86 Gene

Human Gene Mutation Database (HGMD)
CD86
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD86

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD86 Gene

Disorders for CD86 Gene

MalaCards: The human disease database

(27) MalaCards diseases for CD86 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gallbladder squamous cell carcinoma
  • epidermoid gallbladder carcinoma
myocarditis
  • myocardial inflammation
plague
  • yersiniosis
lymphohistiocytoid mesothelioma
skin carcinoma in situ
  • carcinoma in situ of skin
- elite association - COSMIC cancer census association via MalaCards
Search CD86 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD86

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD86: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD86 Gene

Publications for CD86 Gene

  1. A functional CD86 polymorphism associated with asthma and related allergic disorders. (PMID: 17513529) Corydon TJ … Børglum AD (Journal of medical genetics 2007) 3 22 44 58
  2. A polymorphism in the promoter region of the CD86 (B7.2) gene is associated with systemic sclerosis. (PMID: 16712644) Abdallah AM … Welsh KI (International journal of immunogenetics 2006) 3 22 44 58
  3. Evaluation of CD86 gene polymorphism at +1057 position in liver transplant recipients. (PMID: 16223675) Marín LA … Alvarez-López MR (Transplant immunology 2005) 3 22 44 58
  4. Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. (PMID: 12606712) Zhang X … Nathenson SG (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 22 58
  5. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M … Tokunaga K (Genes and immunity 2000) 3 22 44 58

Products for CD86 Gene

Sources for CD86 Gene

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