Aliases for NRXN2 Gene
External Ids for NRXN2 Gene
Previous GeneCards Identifiers for NRXN2 Gene
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
GeneCards Summary for NRXN2 Gene
NRXN2 (Neurexin 2) is a Protein Coding gene. Diseases associated with NRXN2 include Spinal Cord Glioma and Leukocyte Adhesion Deficiency, Type Iii. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and calcium channel regulator activity. An important paralog of this gene is NRXN1.
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.