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Aliases for TRIP11 Gene

Aliases for TRIP11 Gene

  • Thyroid Hormone Receptor Interactor 11 2 3 5
  • Clonal Evolution-Related Gene On Chromosome 14 Protein 3 4
  • Golgi-Associated Microtubule-Binding Protein 210 3 4
  • TR-Interacting Protein 11 3 4
  • GMAP-210 3 4
  • TRIP-11 3 4
  • CEV14 3 4
  • Golgi-Microtubule-Associated Protein Of 210 KDa 3
  • Golgi-Microtubule-Associated-Protein Of 210 KDa 2
  • Thyroid Receptor-Interacting Protein 11 3
  • GMAP210 3
  • TRIP230 3
  • Trip230 4
  • ACG1A 3

External Ids for TRIP11 Gene

Previous GeneCards Identifiers for TRIP11 Gene

  • GC14M089942
  • GC14M086251
  • GC14M090423
  • GC14M090425
  • GC14M091505
  • GC14M092435
  • GC14M072615

Summaries for TRIP11 Gene

Entrez Gene Summary for TRIP11 Gene

  • This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]

GeneCards Summary for TRIP11 Gene

TRIP11 (Thyroid Hormone Receptor Interactor 11) is a Protein Coding gene. Diseases associated with TRIP11 include Achondrogenesis, Type Ia and Achondrogenesis. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and structural constituent of ribosome.

UniProtKB/Swiss-Prot for TRIP11 Gene

  • Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

Gene Wiki entry for TRIP11 Gene

Additional gene information for TRIP11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP11 Gene

Genomics for TRIP11 Gene

GeneHancer (GH) Regulatory Elements for TRIP11 Gene

Promoters and enhancers for TRIP11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J092038 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 668.9 +1.0 1041 3.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B TRIP11 PIR36842 PPP4R3A ATXN3 CPSF2 GOLGA5 TC2N CATSPERB NDUFB1 GC14P091891
GH14J091058 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 46.9 +979.6 979628 6.3 HDGF PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 RPS6KA5 DGLUCY PPP4R3A NRDE2 TRIP11 RPS18P2 RNU7-30P RPL21P11 SNORA11B CCDC88C
GH14J091077 Enhancer 0.9 ENCODE 72.9 +962.6 962553 1 ZFP64 STAT5A BATF IRF4 ZNF121 ZNF213 ATF7 ETV6 BCLAF1 IKZF2 NRDE2 PPP4R3A TRIP11 RPS18P2 RPL21P11 RPS6KA5 RNU7-30P DGLUCY
GH14J091507 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.4 +531.2 531214 4.2 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC PPP4R3A TRIP11 ATXN3 CCDC88C RPS18P2 CPSF2 TC2N ENSG00000258446
GH14J091112 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 16.7 +923.8 923766 8.4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B DGLUCY TRIP11 PPP4R3A NRDE2 RNU7-30P ATXN3 RPS6KA5 RPS18P2 RPL21P11 GC14P091127
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIP11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIP11 gene promoter:
  • HOXA3
  • Ik-2
  • Pax-2a
  • Pax-2
  • FOXD1
  • Pax-5
  • STAT3
  • C/EBPbeta
  • CP2

Genomic Locations for TRIP11 Gene

Genomic Locations for TRIP11 Gene
74,906 bases
Minus strand
74,906 bases
Minus strand

Genomic View for TRIP11 Gene

Genes around TRIP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP11 Gene

Proteins for TRIP11 Gene

  • Protein details for TRIP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thyroid receptor-interacting protein 11
    Protein Accession:
    Secondary Accessions:
    • B2RUT2
    • O14689
    • O15154
    • O95949

    Protein attributes for TRIP11 Gene

    1979 amino acids
    Molecular mass:
    227586 Da
    Quaternary structure:
    • Binds RB1.
    • Sequence=AAB84386.1; Type=Frameshift; Positions=1932, 1955; Evidence={ECO:0000305};

neXtProt entry for TRIP11 Gene

Post-translational modifications for TRIP11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIP11 Gene

No data available for DME Specific Peptides for TRIP11 Gene

Domains & Families for TRIP11 Gene

Gene Families for TRIP11 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TRIP11 Gene


Suggested Antigen Peptide Sequences for TRIP11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Extended rod-like protein with coiled-coil domains.
  • Extended rod-like protein with coiled-coil domains.
genes like me logo Genes that share domains with TRIP11: view

Function for TRIP11 Gene

Molecular function for TRIP11 Gene

UniProtKB/Swiss-Prot Function:
Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.
GENATLAS Biochemistry:
thyroid receptor interacting protein 11,expressed in a wide range of tissues,negatively regulated by the retinoblastoma protein

Phenotypes From GWAS Catalog for TRIP11 Gene

Gene Ontology (GO) - Molecular Function for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 9256431
GO:0005515 protein binding IPI 17438371
genes like me logo Genes that share ontologies with TRIP11: view
genes like me logo Genes that share phenotypes with TRIP11: view

Human Phenotype Ontology for TRIP11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRIP11 Gene

MGI Knock Outs for TRIP11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIP11

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TRIP11 Gene

Localization for TRIP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP11 Gene

Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Associates with the ends of centrosome-nucleated microtubules.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIP11 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
cytoskeleton 4
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0002079 inner acrosomal membrane IEA --
GO:0002080 acrosomal membrane IEA --
GO:0002081 outer acrosomal membrane IEA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with TRIP11: view

Pathways & Interactions for TRIP11 Gene

genes like me logo Genes that share pathways with TRIP11: view

SIGNOR curated interactions for TRIP11 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003281 ventricular septum development IEA --
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IEA --
GO:0006366 transcription by RNA polymerase II TAS 9256431
GO:0006486 protein glycosylation IEA --
GO:0007030 Golgi organization IEA --
genes like me logo Genes that share ontologies with TRIP11: view

Drugs & Compounds for TRIP11 Gene

No Compound Related Data Available

Transcripts for TRIP11 Gene

mRNA/cDNA for TRIP11 Gene

Unigene Clusters for TRIP11 Gene

Thyroid hormone receptor interactor 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIP11

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: -
SP2: -
SP3: - - - - -

ExUns: 22b · 22c

Relevant External Links for TRIP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIP11 Gene

This gene is overexpressed in Platelet (45.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIP11 Gene

Protein tissue co-expression partners for TRIP11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIP11 Gene:


SOURCE GeneReport for Unigene cluster for TRIP11 Gene:


mRNA Expression by UniProt/SwissProt for TRIP11 Gene:

Tissue specificity: Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung.

Evidence on tissue expression from TISSUES for TRIP11 Gene

  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIP11 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • chin
  • ear
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • skull
  • chest wall
  • clavicle
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • abdominal wall
  • intestine
  • kidney
  • liver
  • pelvis
  • placenta
  • uterus
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with TRIP11: view

No data available for mRNA differential expression in normal tissues for TRIP11 Gene

Orthologs for TRIP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIP11 34 33
  • 99.66 (n)
(Canis familiaris)
Mammalia TRIP11 34 33
  • 88.16 (n)
(Bos Taurus)
Mammalia TRIP11 34 33
  • 88.06 (n)
(Mus musculus)
Mammalia Trip11 16 34 33
  • 82.97 (n)
(Rattus norvegicus)
Mammalia Trip11 33
  • 82.4 (n)
(Ornithorhynchus anatinus)
Mammalia TRIP11 34
  • 74 (a)
(Monodelphis domestica)
Mammalia TRIP11 34
  • 73 (a)
(Gallus gallus)
Aves TRIP11 34 33
  • 72.18 (n)
(Anolis carolinensis)
Reptilia TRIP11 34
  • 63 (a)
(Danio rerio)
Actinopterygii trip11 34 33
  • 58.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gmap 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea sql-1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for TRIP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIP11 Gene

Gene Tree for TRIP11 (if available)
Gene Tree for TRIP11 (if available)
Evolutionary constrained regions (ECRs) for TRIP11: view image

Paralogs for TRIP11 Gene

(1) SIMAP similar genes for TRIP11 Gene using alignment to 5 proteins:

  • G3V4R7_HUMAN
  • H0YJ97_HUMAN
genes like me logo Genes that share paralogs with TRIP11: view

No data available for Paralogs for TRIP11 Gene

Variants for TRIP11 Gene

Sequence variations from dbSNP and Humsavar for TRIP11 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs10142576 benign, Achondrogenesis 91,968,613(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1050793334 uncertain-significance, Achondrogenesis 92,039,813(-) G/A 5_prime_UTR_variant, non_coding_transcript_variant
rs1051340 benign, not specified, Achondrogenesis 91,974,722(-) C/A/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1085307101 likely-pathogenic, Achondrogenesis, type IA 92,005,475(-) TATTTAT/TAT coding_sequence_variant, frameshift, non_coding_transcript_variant
rs111335604 likely-benign, Achondrogenesis 91,969,427(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIP11 Gene

Variant ID Type Subtype PubMed ID
nsv1045760 CNV gain 25217958
nsv1134398 CNV deletion 24896259
nsv456395 CNV loss 19166990
nsv523854 CNV gain 19592680
nsv527458 CNV loss 19592680
nsv565519 CNV loss 21841781
nsv977498 CNV duplication 23825009

Variation tolerance for TRIP11 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.54; 95.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIP11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP11 Gene

Disorders for TRIP11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIP11 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
achondrogenesis, type ia
  • acg1a
  • achondrogenesis syndrome
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia. {ECO:0000269 PubMed:9373237}.
  • Achondrogenesis 1A (ACG1A) [MIM:200600]: A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues. {ECO:0000269 PubMed:20089971}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TRIP11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIP11: view

No data available for Genatlas for TRIP11 Gene

Publications for TRIP11 Gene

  1. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. (PMID: 9373237) Abe A … Saito H (Blood 1997) 2 3 4 22 58
  2. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. (PMID: 20089971) Smits P … Beier DR (The New England journal of medicine 2010) 3 4 22 58
  3. GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (PMID: 10189370) Infante C … Rios RM (The Journal of cell biology 1999) 3 4 22 58
  4. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee JW … Moore DD (Molecular endocrinology (Baltimore, Md.) 1995) 2 3 4 58
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58

Products for TRIP11 Gene

Sources for TRIP11 Gene

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