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Aliases for STK17A Gene

Aliases for STK17A Gene

  • Serine/Threonine Kinase 17a 2 3 5
  • DAP Kinase-Related Apoptosis-Inducing Protein Kinase 1 3 4
  • Serine/Threonine Kinase 17a (Apoptosis-Inducing) 2 3
  • Death-Associated Protein Kinase-Related 1 2 3
  • DRAK1 3 4
  • Serine/Threonine-Protein Kinase 17A 3
  • EC 4

External Ids for STK17A Gene

Previous GeneCards Identifiers for STK17A Gene

  • GC07P043269
  • GC07P043363
  • GC07P043395
  • GC07P043589
  • GC07P043507

Summaries for STK17A Gene

Entrez Gene Summary for STK17A Gene

  • This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK17A Gene

STK17A (Serine/Threonine Kinase 17a) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK17B.

UniProtKB/Swiss-Prot for STK17A Gene

  • Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

Additional gene information for STK17A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK17A Gene

Genomics for STK17A Gene

GeneHancer (GH) Regulatory Elements for STK17A Gene

Promoters and enhancers for STK17A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J043582 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 694.5 +5.3 5256 11.1 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 STK17A COA1 DDX56 BLVRA POLM URGCP PIR39554
GH07J043642 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.1 +65.0 65024 10.4 HDGF PKNOX1 SIN3A IRF4 BRCA1 ETS1 ATF7 FOS RUNX3 DEK STK17A COA1 BLVRA TMED4 DDX56 ENSG00000241057 DBNL POLM GC07M043624
GH07J043693 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 27 +111.6 111554 2.6 TFAP4 FOXA2 FOXA3 JUN CEBPB ZNF384 ZNF644 TEAD3 SP1 JUND STK17A BLVRA COA1 MRPS24 LINC00957 DBNL GC07M043624
GH07J043638 Enhancer 1.3 Ensembl ENCODE dbSUPER 26.3 +57.6 57621 3 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ETS1 YY1 NFKBIZ RXRA STK17A BLVRA COA1 LINC00957 GC07M043624
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK17A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STK17A gene promoter:
  • AML1a
  • Hlf
  • FOXJ2 (long isoform)
  • FOXJ2
  • FOXO4
  • FOXC1
  • FOXO1a
  • FOXO1
  • C/EBPalpha

Genomic Locations for STK17A Gene

Genomic Locations for STK17A Gene
44,622 bases
Plus strand
44,622 bases
Plus strand

Genomic View for STK17A Gene

Genes around STK17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK17A Gene

Proteins for STK17A Gene

  • Protein details for STK17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 17A
    Protein Accession:
    Secondary Accessions:
    • A4D1V6
    • Q8IVC8

    Protein attributes for STK17A Gene

    414 amino acids
    Molecular mass:
    46558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STK17A Gene

Post-translational modifications for STK17A Gene

Other Protein References for STK17A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for STK17A
  • Boster Bio Antibodies for STK17A

No data available for DME Specific Peptides for STK17A Gene

Domains & Families for STK17A Gene

Gene Families for STK17A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for STK17A Gene

Suggested Antigen Peptide Sequences for STK17A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
genes like me logo Genes that share domains with STK17A: view

Function for STK17A Gene

Molecular function for STK17A Gene

UniProtKB/Swiss-Prot Function:
Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by thiazolidinedione-type compounds: inhibited by furan- and pyridone- thiazolidinediones.
UniProtKB/Swiss-Prot Induction:
Directly regulated by p53/TP53: induced following cisplatin treatment in a p53/TP53-dependent manner. p53/TP53 activates expression by directly binding to its regulatory regions.

Enzyme Numbers (IUBMB) for STK17A Gene

Gene Ontology (GO) - Molecular Function for STK17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 9786912
GO:0005524 ATP binding IDA 9786912
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK17A: view
genes like me logo Genes that share phenotypes with STK17A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK17A

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK17A Gene

Localization for STK17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK17A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK17A gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 9786912
GO:0005886 plasma membrane IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with STK17A: view

Pathways & Interactions for STK17A Gene

SuperPathways for STK17A Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK17A: view

Pathways by source for STK17A Gene

1 Qiagen pathway for STK17A Gene

SIGNOR curated interactions for STK17A Gene


Gene Ontology (GO) - Biological Process for STK17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 9786912
GO:0006915 apoptotic process IEA --
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IDA 9786912
GO:0043065 positive regulation of apoptotic process IMP 21489989
genes like me logo Genes that share ontologies with STK17A: view

Drugs & Compounds for STK17A Gene

(4) Drugs for STK17A Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for STK17A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with STK17A: view

Transcripts for STK17A Gene

mRNA/cDNA for STK17A Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(232) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STK17A Gene

Serine/threonine kinase 17a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK17A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK17A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -

Relevant External Links for STK17A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK17A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK17A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK17A Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for STK17A Gene

This gene is overexpressed in NK cells (29.5), Spleen (15.1), Placenta (11.6), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK17A Gene

Protein tissue co-expression partners for STK17A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STK17A Gene:


SOURCE GeneReport for Unigene cluster for STK17A Gene:


mRNA Expression by UniProt/SwissProt for STK17A Gene:

Tissue specificity: Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for STK17A Gene

  • Intestine(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with STK17A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STK17A Gene

Orthologs for STK17A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK17A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STK17A 34 33
  • 99.76 (n)
(Canis familiaris)
Mammalia STK17A 34
  • 92 (a)
(Bos Taurus)
Mammalia STK17A 34 33
  • 88.49 (n)
(Ornithorhynchus anatinus)
Mammalia STK17A 34
  • 83 (a)
(Monodelphis domestica)
Mammalia STK17A 34
  • 66 (a)
(Gallus gallus)
Aves STK17A 34 33
  • 76.07 (n)
(Anolis carolinensis)
Reptilia STK17A 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk17a 33
  • 68.56 (n)
Str.7458 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.27469 33
(Danio rerio)
Actinopterygii stk17a 34 33
  • 64.63 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Drak 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea unc-22 34
  • 2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEK1 34
  • 15 (a)
(Zea mays)
Liliopsida Zm.41 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for STK17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK17A Gene

Gene Tree for STK17A (if available)
Gene Tree for STK17A (if available)
Evolutionary constrained regions (ECRs) for STK17A: view image

Paralogs for STK17A Gene

Paralogs for STK17A Gene

genes like me logo Genes that share paralogs with STK17A: view

Variants for STK17A Gene

Sequence variations from dbSNP and Humsavar for STK17A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000008037 -- 43,615,780(+) A/G intron_variant
rs1000122265 -- 43,602,505(+) A/G intron_variant
rs1000124924 -- 43,590,692(+) A/G intron_variant
rs1000176967 -- 43,591,129(+) G/A intron_variant
rs1000234734 -- 43,583,949(+) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STK17A Gene

Variant ID Type Subtype PubMed ID
dgv11292n54 CNV loss 21841781
dgv11293n54 CNV loss 21841781
dgv11294n54 CNV loss 21841781
dgv11295n54 CNV loss 21841781
dgv11296n54 CNV loss 21841781
dgv1903e212 CNV loss 25503493
dgv1904e212 CNV loss 25503493
esv22147 CNV loss 19812545
esv2665229 CNV deletion 23128226
esv3541556 CNV deletion 23714750
esv3612993 CNV gain 21293372
esv3612996 CNV gain 21293372
esv3612997 CNV loss 21293372
esv3612999 CNV loss 21293372
nsv518728 CNV loss 19592680
nsv606717 CNV loss 21841781
nsv606722 CNV loss 21841781
nsv606736 CNV loss 21841781
nsv606744 CNV loss 21841781
nsv819718 CNV loss 19587683

Variation tolerance for STK17A Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK17A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK17A Gene

Disorders for STK17A Gene

Additional Disease Information for STK17A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STK17A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK17A Gene

Publications for STK17A Gene

  1. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. (PMID: 9786912) Sanjo H … Akira S (The Journal of biological chemistry 1998) 2 3 4 58
  2. Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. (PMID: 21489989) Mao P … Spinella MJ (The Journal of biological chemistry 2011) 3 4 58
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  4. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I … Robledo M (PLoS genetics 2009) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for STK17A Gene

Sources for STK17A Gene

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