Aliases for GCM2 Gene
External Ids for GCM2 Gene
Previous HGNC Symbols for GCM2 Gene
Previous GeneCards Identifiers for GCM2 Gene
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008]
GeneCards Summary for GCM2 Gene
GCM2 (Glial Cells Missing Homolog 2) is a Protein Coding gene. Diseases associated with GCM2 include Hypoparathyroidism, Familial Isolated and Hyperparathyroidism 4. Among its related pathways are Parathyroid hormone synthesis, secretion and action. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is GCM1.
UniProtKB/Swiss-Prot for GCM2 Gene
Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.