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Aliases for SCGB3A1 Gene

Aliases for SCGB3A1 Gene

  • Secretoglobin Family 3A Member 1 2 3 3 5
  • Pneumo Secretory Protein 2 2 3 4
  • Uteroglobin-Related Protein 2 3 4
  • Cytokine High In Normal-1 2 3
  • High In Normal 1 3 4
  • Cytokine HIN-1 3 4
  • PnSP-2 3 4
  • UGRP2 3 4
  • HIN1 3 4
  • HIN-1 3
  • LU105 3
  • PNSP2 4

External Ids for SCGB3A1 Gene

Previous GeneCards Identifiers for SCGB3A1 Gene

  • GC05U990164
  • GC05M180995
  • GC05M180081
  • GC05M180126
  • GC05M179949
  • GC05M180017
  • GC05M174741

Summaries for SCGB3A1 Gene

GeneCards Summary for SCGB3A1 Gene

SCGB3A1 (Secretoglobin Family 3A Member 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is SCGB3A2.

UniProtKB/Swiss-Prot for SCGB3A1 Gene

  • Secreted cytokine-like protein. Inhibits cell growth in vitro.

Gene Wiki entry for SCGB3A1 Gene

Additional gene information for SCGB3A1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB3A1 Gene

Genomics for SCGB3A1 Gene

GeneHancer (GH) Regulatory Elements for SCGB3A1 Gene

Promoters and enhancers for SCGB3A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J180591 Promoter 0.5 EPDnew 650.7 +0.0 21 0.1 SCGB3A1 GC05P180589
GH05J180560 Enhancer 0.9 ENCODE 52.4 +29.1 29051 3.6 HDGF HDAC1 PKNOX1 ARNT TCF12 GATA2 ZNF143 SIRT6 ATF7 RUNX3 SCGB3A1 FLT4 CNOT6 ENSG00000248367 GC05P180580 LOC100329129
GH05J180554 Enhancer 1 ENCODE 40.5 +36.3 36268 2.5 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 ARID2 FOS SCGB3A1 LOC100329129 GC05P180580 CNOT6
GH05J180548 Enhancer 0.7 ENCODE 29.3 +42.8 42820 1.2 HDAC1 MEIS2 TEAD4 TAL1 BACH1 MCM2 FOSL1 ZNF316 NFE2 MAFK SCGB3A1 LOC100329129 GC05P180580 CNOT6
GH05J180493 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.1 +96.2 96174 4.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A YBX1 ZNF2 CNOT6 HNRNPH1 MAML1 MRNIP ENSG00000233937 TRIM52 ZFP62 RUFY1 RACK1 LOC100420514
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCGB3A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCGB3A1 gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for SCGB3A1 Gene

Genomic Locations for SCGB3A1 Gene
chr5:180,590,103-180,591,540
(GRCh38/hg38)
Size:
1,438 bases
Orientation:
Minus strand
chr5:180,017,103-180,018,540
(GRCh37/hg19)
Size:
1,438 bases
Orientation:
Minus strand

Genomic View for SCGB3A1 Gene

Genes around SCGB3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB3A1 Gene

Proteins for SCGB3A1 Gene

  • Protein details for SCGB3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QR1-SG3A1_HUMAN
    Recommended name:
    Secretoglobin family 3A member 1
    Protein Accession:
    Q96QR1
    Secondary Accessions:
    • Q96PL0

    Protein attributes for SCGB3A1 Gene

    Size:
    104 amino acids
    Molecular mass:
    10100 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for SCGB3A1 Gene

Post-translational modifications for SCGB3A1 Gene

No Post-translational modifications

Other Protein References for SCGB3A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB3A1 Gene

Domains & Families for SCGB3A1 Gene

Gene Families for SCGB3A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SCGB3A1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SCGB3A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QR1

UniProtKB/Swiss-Prot:

SG3A1_HUMAN :
  • Belongs to the secretoglobin family. UGRP subfamily.
Family:
  • Belongs to the secretoglobin family. UGRP subfamily.
genes like me logo Genes that share domains with SCGB3A1: view

Function for SCGB3A1 Gene

Molecular function for SCGB3A1 Gene

UniProtKB/Swiss-Prot Function:
Secreted cytokine-like protein. Inhibits cell growth in vitro.

Gene Ontology (GO) - Molecular Function for SCGB3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 11481438
genes like me logo Genes that share ontologies with SCGB3A1: view
genes like me logo Genes that share phenotypes with SCGB3A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCGB3A1

miRNA for SCGB3A1 Gene

miRTarBase miRNAs that target SCGB3A1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCGB3A1 Gene

Localization for SCGB3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB3A1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB3A1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IEA 11481438
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with SCGB3A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB3A1 Gene

Pathways & Interactions for SCGB3A1 Gene

SuperPathways for SCGB3A1 Gene

No Data Available

Interacting Proteins for SCGB3A1 Gene

Gene Ontology (GO) - Biological Process for SCGB3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010469 regulation of signaling receptor activity IEA --
GO:0030308 negative regulation of cell growth NAS 11481438
GO:0042127 regulation of cell proliferation NAS 11481438
GO:1901741 positive regulation of myoblast fusion IEA --
genes like me logo Genes that share ontologies with SCGB3A1: view

No data available for Pathways by source and SIGNOR curated interactions for SCGB3A1 Gene

Drugs & Compounds for SCGB3A1 Gene

(1) Additional Compounds for SCGB3A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SCGB3A1: view

Transcripts for SCGB3A1 Gene

mRNA/cDNA for SCGB3A1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(55) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB3A1 Gene

Secretoglobin, family 3A, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB3A1 Gene

No ASD Table

Relevant External Links for SCGB3A1 Gene

GeneLoc Exon Structure for
SCGB3A1
ECgene alternative splicing isoforms for
SCGB3A1

Expression for SCGB3A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCGB3A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCGB3A1 Gene

This gene is overexpressed in Minor Salivary Gland (x24.1), Cervix - Endocervix (x12.0), and Lung (x8.1).

Protein differential expression in normal tissues from HIPED for SCGB3A1 Gene

This gene is overexpressed in Fetal gut (56.9) and Plasma (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB3A1 Gene



Protein tissue co-expression partners for SCGB3A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCGB3A1 Gene:

SCGB3A1

SOURCE GeneReport for Unigene cluster for SCGB3A1 Gene:

Hs.62492

mRNA Expression by UniProt/SwissProt for SCGB3A1 Gene:

Q96QR1-SG3A1_HUMAN
Tissue specificity: Highly expressed in lung and prostate (PubMed:11481438). Also found in mammary gland, spleen, pancreas, testis and liver (PubMed:11481438). Detected throughout the airway epithelium in lung, with highest expression in large airways (PubMed:12406855). Found in lung submucosal glands where it localizes to acinar and ductile cells (PubMed:12406855). Not detected in respiratory bronchioles, alveolar ducts or alveolar epithelium (PubMed:12406855). In mammary gland, specifically localizes to luminal epithelial cells (PubMed:11481438).

Evidence on tissue expression from TISSUES for SCGB3A1 Gene

  • Nervous system(4)
  • Lung(3.3)
genes like me logo Genes that share expression patterns with SCGB3A1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB3A1 Gene

Orthologs for SCGB3A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB3A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB3A1 34 33
  • 98.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scgb3a1 33
  • 70.63 (n)
mouse
(Mus musculus)
Mammalia Scgb3a1 16 34 33
  • 69.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SCGB3A1 34
  • 43 (a)
OneToOne
Species where no ortholog for SCGB3A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB3A1 Gene

ENSEMBL:
Gene Tree for SCGB3A1 (if available)
TreeFam:
Gene Tree for SCGB3A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCGB3A1: view image

Paralogs for SCGB3A1 Gene

Paralogs for SCGB3A1 Gene

(2) SIMAP similar genes for SCGB3A1 Gene using alignment to 1 proteins:

  • SG3A1_HUMAN
genes like me logo Genes that share paralogs with SCGB3A1: view

Variants for SCGB3A1 Gene

Sequence variations from dbSNP and Humsavar for SCGB3A1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000275961 -- 180,591,282(-) G/A intron_variant
rs1000423769 -- 180,593,293(-) C/A upstream_transcript_variant
rs1000558855 -- 180,590,106(-) G/A 3_prime_UTR_variant
rs1000610987 -- 180,590,354(-) C/A/T intron_variant
rs1000732168 -- 180,591,565(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SCGB3A1 Gene

Variant ID Type Subtype PubMed ID
esv2762572 CNV gain 21179565
nsv1026417 CNV gain 25217958
nsv509111 CNV insertion 20534489

Variation tolerance for SCGB3A1 Gene

Gene Damage Index Score: 0.54; 11.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCGB3A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB3A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB3A1 Gene

Disorders for SCGB3A1 Gene

Additional Disease Information for SCGB3A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SCGB3A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCGB3A1 Gene

Publications for SCGB3A1 Gene

  1. HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. (PMID: 11481438) Krop IE … Polyak K (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 22 58
  2. Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. (PMID: 12406855) Reynolds SD … Stripp BR (American journal of respiratory and critical care medicine 2002) 3 4 22 58
  3. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3 58
  4. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 44 58
  5. Promoter methylation of HIN-1 in the progression to esophageal squamous cancer. (PMID: 19098448) Guo M … Carraway HE (Epigenetics 2008) 3 22 58

Products for SCGB3A1 Gene

Sources for SCGB3A1 Gene

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