Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTA2 Gene

Aliases for MTA2 Gene

  • Metastasis Associated 1 Family Member 2 2 3 5
  • Metastasis Associated Gene Family, Member 2 2 3
  • P53 Target Protein In Deacetylase Complex 3 4
  • Metastasis-Associated 1-Like 1 3 4
  • MTA1-L1 Protein 3 4
  • MTA1L1 3 4
  • PID 3 4
  • Metastasis -Associated Gene 1-Like 1 3
  • Metastasis-Associated Protein MTA2 3
  • Metastasis-Associated Protein 2 3

External Ids for MTA2 Gene

Previous HGNC Symbols for MTA2 Gene

  • MTA1L1

Previous GeneCards Identifiers for MTA2 Gene

  • GC11M062136
  • GC11M062119
  • GC11M062360
  • GC11M058689

Summaries for MTA2 Gene

Entrez Gene Summary for MTA2 Gene

  • This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

GeneCards Summary for MTA2 Gene

MTA2 (Metastasis Associated 1 Family Member 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is MTA1.

UniProtKB/Swiss-Prot for MTA2 Gene

  • May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Gene Wiki entry for MTA2 Gene

Additional gene information for MTA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTA2 Gene

Genomics for MTA2 Gene

GeneHancer (GH) Regulatory Elements for MTA2 Gene

Promoters and enhancers for MTA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062597 Promoter/Enhancer 2.3 VISTA EPDnew Ensembl ENCODE 663.4 +1.2 1220 6.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 IRF4 MTA2 ROM1 EML3 TTC9C SNHG1 CSKMT GANAB LOC105369332 EEF1G TUT1
GH11J062838 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 98.8 -239.0 -239006 4.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WDR74 GC11M062842 RNU2-2P NXF1 CSKMT INTS5 SNHG1 UBXN1 MTA2 GANAB
GH11J062852 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 72.1 -254.0 -253997 5.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NXF1 SNHG1 SLC3A2 ENSG00000278527 GC11M062934 GC11M062938 GC11M062939 GC11M062942 SNORD25 SNORD26
GH11J061960 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 52.2 +632.9 632916 16.4 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 FTH1 GC11M061968 GC11M061969 GC11M061970 LOC399900 NXF1 INTS5 LOC105369332 CPSF7 UBXN1
GH11J062669 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 64.4 -69.6 -69649 4.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 GC11M062588 LBHD1 UQCC3 EML3 LOC105369332 MTA2 GANAB WDR74 STX5 CSKMT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTA2 gene promoter:
  • p53
  • deltaCREB
  • CREB
  • Sp1
  • CUTL1
  • YY1

Genomic Locations for MTA2 Gene

Genomic Locations for MTA2 Gene
chr11:62,593,203-62,601,840
(GRCh38/hg38)
Size:
8,638 bases
Orientation:
Minus strand
chr11:62,360,675-62,369,312
(GRCh37/hg19)
Size:
8,638 bases
Orientation:
Minus strand

Genomic View for MTA2 Gene

Genes around MTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTA2 Gene

Proteins for MTA2 Gene

  • Protein details for MTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94776-MTA2_HUMAN
    Recommended name:
    Metastasis-associated protein MTA2
    Protein Accession:
    O94776
    Secondary Accessions:
    • Q68DB1
    • Q9UQB5

    Protein attributes for MTA2 Gene

    Size:
    668 amino acids
    Molecular mass:
    75023 Da
    Quaternary structure:
    • Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with PIMREG. Interacts with NACC2.
    SequenceCaution:
    • Sequence=AAH23656.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTA2 Gene

Post-translational modifications for MTA2 Gene

  • Ubiquitination at Lys611, Lys522, isoforms=2508, and Lys152
  • Modification sites at PhosphoSitePlus

Other Protein References for MTA2 Gene

No data available for DME Specific Peptides for MTA2 Gene

Domains & Families for MTA2 Gene

Gene Families for MTA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for MTA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MTA2: view

No data available for UniProtKB/Swiss-Prot for MTA2 Gene

Function for MTA2 Gene

Molecular function for MTA2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Phenotypes From GWAS Catalog for MTA2 Gene

Gene Ontology (GO) - Molecular Function for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 contributes_to transcription regulatory region sequence-specific DNA binding IDA 16217013
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0000989 transcription factor activity, transcription factor binding IEA --
GO:0001085 RNA polymerase II transcription factor binding IPI 15920471
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
genes like me logo Genes that share ontologies with MTA2: view
genes like me logo Genes that share phenotypes with MTA2: view

Animal Models for MTA2 Gene

MGI Knock Outs for MTA2:
  • Mta2 Mta2<tm1.1Yzha>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTA2 Gene

Localization for MTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex TAS 10444591
GO:0000790 nuclear chromatin HDA 16217013
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 15920471
genes like me logo Genes that share ontologies with MTA2: view

Pathways & Interactions for MTA2 Gene

genes like me logo Genes that share pathways with MTA2: view

Gene Ontology (GO) - Biological Process for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006306 DNA methylation IEA --
GO:0006333 chromatin assembly or disassembly TAS 10444591
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010762 regulation of fibroblast migration IEA --
genes like me logo Genes that share ontologies with MTA2: view

No data available for SIGNOR curated interactions for MTA2 Gene

Drugs & Compounds for MTA2 Gene

(1) Drugs for MTA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MTA2: view

Transcripts for MTA2 Gene

mRNA/cDNA for MTA2 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTA2 Gene

Metastasis associated 1 family, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1:
SP2:
SP3: - - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 20a · 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MTA2 Gene

GeneLoc Exon Structure for
MTA2
ECgene alternative splicing isoforms for
MTA2

Expression for MTA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTA2 Gene

Protein differential expression in normal tissues from HIPED for MTA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Breast (8.6), and Lymph node (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTA2 Gene



Protein tissue co-expression partners for MTA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MTA2 Gene:

MTA2

SOURCE GeneReport for Unigene cluster for MTA2 Gene:

Hs.173043

mRNA Expression by UniProt/SwissProt for MTA2 Gene:

O94776-MTA2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for MTA2 Gene

  • Nervous system(4.3)
  • Eye(4.2)
  • Liver(4.2)
  • Lymph node(2.6)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MTA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTA2 Gene

Orthologs for MTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTA2 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTA2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTA2 34 33
  • 93.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MTA2 34 33
  • 93.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mta2 16 34 33
  • 91.17 (n)
rat
(Rattus norvegicus)
Mammalia Mta2 33
  • 90.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MTA2 34
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTA2 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mta2 33
  • 75.45 (n)
Str.6927 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.545 33
zebrafish
(Danio rerio)
Actinopterygii mta2 34 33
  • 71.96 (n)
OneToOne
wufi29g02 33
fruit fly
(Drosophila melanogaster)
Insecta MTA1-like 34
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lin-40 34
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToOne
Species where no ortholog for MTA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTA2 Gene

ENSEMBL:
Gene Tree for MTA2 (if available)
TreeFam:
Gene Tree for MTA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MTA2: view image

Paralogs for MTA2 Gene

Paralogs for MTA2 Gene

(4) SIMAP similar genes for MTA2 Gene using alignment to 1 proteins:

  • MTA2_HUMAN
genes like me logo Genes that share paralogs with MTA2: view

Variants for MTA2 Gene

Sequence variations from dbSNP and Humsavar for MTA2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000199823 -- 62,594,840(-) A/C intron_variant
rs1000446112 -- 62,598,835(-) A/G intron_variant
rs1000692205 -- 62,601,142(-) C/T 5_prime_UTR_variant, intron_variant
rs1001183217 -- 62,598,187(-) G/A intron_variant
rs1001237165 -- 62,598,444(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MTA2 Gene

Variant ID Type Subtype PubMed ID
esv3579735 CNV loss 25503493
esv3584599 CNV gain 24956385
nsv514630 CNV gain 21397061
nsv555174 CNV gain 21841781
nsv825939 CNV gain 20364138
nsv832180 CNV loss 17160897
nsv832182 CNV gain+loss 17160897

Variation tolerance for MTA2 Gene

Residual Variation Intolerance Score: 3.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTA2 Gene

Disorders for MTA2 Gene

Additional Disease Information for MTA2

No disorders were found for MTA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTA2 Gene

Publications for MTA2 Gene

  1. Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1. (PMID: 9929979) Futamura M … Tokino T (Journal of human genetics 1999) 2 3 4 22 58
  2. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. (PMID: 22926524) Xuan C … Shang Y (Oncogene 2013) 3 4 58
  3. Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation. (PMID: 19702911) Lee H … Kim KW (Journal of gastroenterology and hepatology 2009) 3 22 58
  4. Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons. (PMID: 18413351) Lee C … Agoston DV (Cerebral cortex (New York, N.Y. : 1991) 2008) 3 22 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for MTA2 Gene

Sources for MTA2 Gene

  • (128)