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Aliases for CCNB2 Gene

Aliases for CCNB2 Gene

  • Cyclin B2 2 3 5
  • G2/Mitotic-Specific Cyclin-B2 3
  • HsT17299 3

External Ids for CCNB2 Gene

Previous GeneCards Identifiers for CCNB2 Gene

  • GC15P054954
  • GC15P052444
  • GC15P056976
  • GC15P057113
  • GC15P057184
  • GC15P059397
  • GC15P036219

Summaries for CCNB2 Gene

Entrez Gene Summary for CCNB2 Gene

  • Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNB2 Gene

CCNB2 (Cyclin B2) is a Protein Coding gene. Diseases associated with CCNB2 include Anauxetic Dysplasia 1 and Breast Cancer. Among its related pathways are Cyclin A/B1 associated events during G2/M transition and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNB1.

UniProtKB/Swiss-Prot for CCNB2 Gene

  • Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Gene Wiki entry for CCNB2 Gene

Additional gene information for CCNB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNB2 Gene

Genomics for CCNB2 Gene

GeneHancer (GH) Regulatory Elements for CCNB2 Gene

Promoters and enhancers for CCNB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J059104 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.3 295 2.1 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CCNB2 SLTM BNIP2 PIGHP1 PIR47582 GC15M059055
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNB2 gene promoter:
  • POU2F1
  • IRF-1
  • POU2F1a
  • Nkx3-1 v2
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v1
  • Nkx3-1
  • Sox9
  • GATA-2

Genomic Locations for CCNB2 Gene

Genomic Locations for CCNB2 Gene
19,968 bases
Plus strand
19,968 bases
Plus strand

Genomic View for CCNB2 Gene

Genes around CCNB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB2 Gene

Proteins for CCNB2 Gene

  • Protein details for CCNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G2/mitotic-specific cyclin-B2
    Protein Accession:
    Secondary Accessions:
    • B3KM93
    • Q6FI99

    Protein attributes for CCNB2 Gene

    398 amino acids
    Molecular mass:
    45282 Da
    Quaternary structure:
    • Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

neXtProt entry for CCNB2 Gene

Post-translational modifications for CCNB2 Gene

  • Ubiquitination at posLast=367367, posLast=360360, and Lys328
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNB2 Gene

Domains & Families for CCNB2 Gene

Gene Families for CCNB2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for CCNB2 Gene

Suggested Antigen Peptide Sequences for CCNB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin AB subfamily.
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNB2: view

Function for CCNB2 Gene

Molecular function for CCNB2 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Gene Ontology (GO) - Molecular Function for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 15232106
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with CCNB2: view
genes like me logo Genes that share phenotypes with CCNB2: view

Animal Models for CCNB2 Gene

MGI Knock Outs for CCNB2:

Animal Model Products

miRNA for CCNB2 Gene

Clone Products

  • Addgene plasmids for CCNB2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNB2 Gene

Localization for CCNB2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNB2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol IDA,TAS --
GO:0015630 microtubule cytoskeleton IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCNB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNB2 Gene

Pathways & Interactions for CCNB2 Gene

genes like me logo Genes that share pathways with CCNB2: view

Gene Ontology (GO) - Biological Process for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0001701 in utero embryonic development IEA --
GO:0007049 cell cycle IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0040007 growth IEA --
genes like me logo Genes that share ontologies with CCNB2: view

No data available for SIGNOR curated interactions for CCNB2 Gene

Drugs & Compounds for CCNB2 Gene

(3) Drugs for CCNB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCNB2: view

Transcripts for CCNB2 Gene

mRNA/cDNA for CCNB2 Gene

Unigene Clusters for CCNB2 Gene

Cyclin B2:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCNB2

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9

Relevant External Links for CCNB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNB2 Gene

mRNA differential expression in normal tissues according to GTEx for CCNB2 Gene

This gene is overexpressed in Testis (x12.5).

Protein differential expression in normal tissues from HIPED for CCNB2 Gene

This gene is overexpressed in Testis (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNB2 Gene

Protein tissue co-expression partners for CCNB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNB2 Gene:


SOURCE GeneReport for Unigene cluster for CCNB2 Gene:


Evidence on tissue expression from TISSUES for CCNB2 Gene

  • Nervous system(4.5)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with CCNB2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNB2 Gene

Orthologs for CCNB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCNB2 34 33
  • 99.58 (n)
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
CCNB2 33
  • 90.85 (n)
-- 34
  • 83 (a)
(Bos Taurus)
Mammalia CCNB2 34 33
  • 87.86 (n)
(Rattus norvegicus)
Mammalia Ccnb2 33
  • 87.57 (n)
(Mus musculus)
Mammalia Ccnb2 16 34 33
  • 86.62 (n)
(Monodelphis domestica)
Mammalia CCNB2 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia CCNB2 34
  • 74 (a)
(Gallus gallus)
Aves CCNB2 34 33
  • 69.71 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnb2 33
  • 63.73 (n)
Ccnb2 33
African clawed frog
(Xenopus laevis)
Amphibia LOC397743 33
(Danio rerio)
Actinopterygii ccnb2 34 33
  • 62.28 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4250 33
fruit fly
(Drosophila melanogaster)
Insecta CycB 34 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea cyb-2.1 34 35
  • 30 (a)
cyb-1 34 35
  • 30 (a)
cyb-2.2 34 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB2 36 34 33
  • 54.32 (n)
CLB3 34
  • 27 (a)
CLB1 34
  • 27 (a)
CLB6 34
  • 23 (a)
CLB4 34
  • 22 (a)
CLB5 34
  • 22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15543g 33
  • 50.38 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR099W 33
  • 48.39 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCB2;4 33
  • 52.17 (n)
(Glycine max)
eudicotyledons Gma.174 33
(Oryza sativa)
Liliopsida Os04g0563700 33
  • 49.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3299 34
  • 39 (a)
Species where no ortholog for CCNB2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNB2 Gene

Gene Tree for CCNB2 (if available)
Gene Tree for CCNB2 (if available)
Evolutionary constrained regions (ECRs) for CCNB2: view image

Paralogs for CCNB2 Gene

Paralogs for CCNB2 Gene

(5) SIMAP similar genes for CCNB2 Gene using alignment to 2 proteins:

  • H0YMP3_HUMAN Pseudogenes for CCNB2 Gene

genes like me logo Genes that share paralogs with CCNB2: view

Variants for CCNB2 Gene

Sequence variations from dbSNP and Humsavar for CCNB2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000387606 -- 59,124,600(+) G/T intron_variant
rs1000682334 -- 59,115,216(+) G/A intron_variant
rs1000779499 -- 59,120,579(+) G/A intron_variant
rs1000985479 -- 59,125,367(+) G/C downstream_transcript_variant
rs1001003991 -- 59,109,589(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNB2 Gene

Variant ID Type Subtype PubMed ID
esv3636638 CNV loss 21293372
nsv527307 CNV gain 19592680
nsv7266 OTHER inversion 18451855
nsv833025 CNV gain 17160897

Variation tolerance for CCNB2 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNB2 Gene

Disorders for CCNB2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCNB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
anauxetic dysplasia 1
  • anxd1
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search CCNB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNB2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCNB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNB2 Gene

Publications for CCNB2 Gene

  1. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham JM … Goode EL (British journal of cancer 2009) 3 44 58
  2. [Molecular mechanism of radiosensitizing effect of paclitaxel]. (PMID: 19664331) Weng WW … Hong CJ (Ai zheng = Aizheng = Chinese journal of cancer 2009) 3 22 58
  3. HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. (PMID: 19223528) De Martino I … Fusco A (Cancer research 2009) 3 22 58
  4. Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2. (PMID: 17533373) Bellanger S … Sobczak-Thépot J (Oncogene 2007) 3 22 58
  5. NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma. (PMID: 17289878) Park SH … Kim DG (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 22 58

Products for CCNB2 Gene

Sources for CCNB2 Gene

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