Aliases for KRT75 Gene
External Ids for KRT75 Gene
Previous GeneCards Identifiers for KRT75 Gene
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008]
GeneCards Summary for KRT75 Gene
KRT75 (Keratin 75) is a Protein Coding gene. Diseases associated with KRT75 include Pseudofolliculitis Barbae and Loose Anagen Hair Syndrome. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT5.
UniProtKB/Swiss-Prot for KRT75 Gene
Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.