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Aliases for TRIM41 Gene

Aliases for TRIM41 Gene

  • Tripartite Motif Containing 41 2 3 5
  • RING-Finger Protein That Interacts With C Kinase 2 3
  • RING Finger-Interacting Protein With C Kinase 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM41 3 4
  • RINCK 3 4
  • Tripartite Motif-Containing Protein 41 4
  • E3 Ubiquitin-Protein Ligase TRIM41 3
  • Tripartite Motif-Containing 41 2
  • EC 4

External Ids for TRIM41 Gene

Previous GeneCards Identifiers for TRIM41 Gene

  • GC05M181702
  • GC05P180712
  • GC05P180759
  • GC05P180582
  • GC05P180649
  • GC05P175377

Summaries for TRIM41 Gene

Entrez Gene Summary for TRIM41 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TRIM41 Gene

TRIM41 (Tripartite Motif Containing 41) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot for TRIM41 Gene

  • Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.

Gene Wiki entry for TRIM41 Gene

Additional gene information for TRIM41 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM41 Gene

Genomics for TRIM41 Gene

GeneHancer (GH) Regulatory Elements for TRIM41 Gene

Promoters and enhancers for TRIM41 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J181221 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 753 4.4 CLOCK ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 MIR4638 PIR62653 PIR33457 TRIM41 TRK-CTT2-3 TRV-CAC1-5 ENSG00000233937 TRIM52 RACK1 CNOT6
GH05J181280 Enhancer 1.1 Ensembl ENCODE 10.9 +58.9 58899 2.2 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A POLR2B FOS ATF7 NFYC ENSG00000248103 TRIM52-AS1 RACK1 TRIM52 ENSG00000233937 ENSG00000247049 TRIM41 TRIM7 ENSG00000250900 ENSG00000274525
GH05J181184 Enhancer 0.9 ENCODE 11.9 -40.4 -40363 0.2 HDGF ELF3 RB1 ARID4B SIN3A RAD21 ZNF614 ARID2 ZNF143 ATF7 ENSG00000248514 TRIM7 TRIM41 ENSG00000247049 GC05P181179 TRL-AAG2-1
GH05J181182 Enhancer 0.5 ENCODE 11.9 -39.9 -39903 0.3 CTCF E2F1 ERF KDM1A MLLT1 RBPJ ZXDB ENSG00000248514 TRIM7 TRIM41 ENSG00000247049 GC05P181179 TRL-AAG2-1
GH05J181179 Enhancer 0.5 dbSUPER 11.9 -42.7 -42670 1.2 MITF IKZF1 ZNF24 ZNF2 IKZF2 ZBTB17 GC05P181179 TRIM7 TRIM41 ENSG00000247049 ENSG00000248514 ENSG00000233937 RACK1 MGAT1 ENSG00000248103 TRL-AAG2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM41 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM41 gene promoter:
  • AREB6
  • Sp1
  • FAC1
  • Tal-1
  • E47
  • HEN1
  • MyoD

Genomic Locations for TRIM41 Gene

Genomic Locations for TRIM41 Gene
13,311 bases
Plus strand
13,311 bases
Plus strand

Genomic View for TRIM41 Gene

Genes around TRIM41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM41 Gene

Proteins for TRIM41 Gene

  • Protein details for TRIM41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM41
    Protein Accession:
    Secondary Accessions:
    • B3KNJ6
    • D3DWR9
    • Q5BKT0
    • Q7L484
    • Q96Q10
    • Q9BSL8

    Protein attributes for TRIM41 Gene

    630 amino acids
    Molecular mass:
    71670 Da
    Quaternary structure:
    • Interacts with PRKCA.

    Three dimensional structures from OCA and Proteopedia for TRIM41 Gene

    Alternative splice isoforms for TRIM41 Gene


neXtProt entry for TRIM41 Gene

Post-translational modifications for TRIM41 Gene

  • Auto-ubiquitinated.
  • Ubiquitination at posLast=575575, posLast=557557, posLast=512512, and posLast=307307
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRIM41 Gene

Domains & Families for TRIM41 Gene

Gene Families for TRIM41 Gene

Suggested Antigen Peptide Sequences for TRIM41 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM41: view

Function for TRIM41 Gene

Molecular function for TRIM41 Gene

UniProtKB/Swiss-Prot Function:
Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for TRIM41 Gene

Gene Ontology (GO) - Molecular Function for TRIM41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 22493164
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM41: view
genes like me logo Genes that share phenotypes with TRIM41: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM41

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM41 Gene

Localization for TRIM41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM41 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM41 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with TRIM41: view

Pathways & Interactions for TRIM41 Gene

genes like me logo Genes that share pathways with TRIM41: view

UniProtKB/Swiss-Prot Q8WV44-TRI41_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM41: view

No data available for SIGNOR curated interactions for TRIM41 Gene

Drugs & Compounds for TRIM41 Gene

No Compound Related Data Available

Transcripts for TRIM41 Gene

Unigene Clusters for TRIM41 Gene

Tripartite motif containing 41:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM41

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM41 Gene

No ASD Table

Relevant External Links for TRIM41 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM41 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM41 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for TRIM41 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.8), Pancreas (9.9), Blymphocyte (7.5), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM41 Gene

Protein tissue co-expression partners for TRIM41 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM41 Gene:


SOURCE GeneReport for Unigene cluster for TRIM41 Gene:


mRNA Expression by UniProt/SwissProt for TRIM41 Gene:

Tissue specificity: Expressed in multiple tissues with the highest levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for TRIM41 Gene

  • Pancreas(4.5)
  • Liver(4.4)
  • Lung(4.2)
  • Nervous system(3.8)
  • Eye(2)
genes like me logo Genes that share expression patterns with TRIM41: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM41 Gene

Orthologs for TRIM41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM41 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM41 33
  • 99.33 (n)
(Canis familiaris)
Mammalia TRIM41 34 33
  • 91.2 (n)
(Bos Taurus)
Mammalia TRIM41 34 33
  • 91.04 (n)
(Rattus norvegicus)
Mammalia Trim41 33
  • 88.16 (n)
(Mus musculus)
Mammalia Trim41 16 34 33
  • 87.39 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 28 (a)
(Gallus gallus)
Aves TRIM41 34 33
  • 64.21 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 54 (a)
(Danio rerio)
Actinopterygii trim105 34
  • 25 (a)
Species where no ortholog for TRIM41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM41 Gene

Gene Tree for TRIM41 (if available)
Gene Tree for TRIM41 (if available)
Evolutionary constrained regions (ECRs) for TRIM41: view image

Paralogs for TRIM41 Gene

(33) SIMAP similar genes for TRIM41 Gene using alignment to 5 proteins:

  • A1A4S2_HUMAN
  • H0Y9T3_HUMAN
genes like me logo Genes that share paralogs with TRIM41: view

Variants for TRIM41 Gene

Sequence variations from dbSNP and Humsavar for TRIM41 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000123221 -- 181,231,791(+) C/T intron_variant
rs1000433535 -- 181,222,227(+) G/A upstream_transcript_variant
rs1000508332 -- 181,222,143(+) C/T upstream_transcript_variant
rs1000781107 -- 181,227,360(+) TTTTTTTT/TTTTTTTTT intron_variant
rs1000859379 -- 181,232,013(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM41 Gene

Variant ID Type Subtype PubMed ID
dgv5862n100 CNV gain 25217958
nsv428133 CNV gain 18775914
nsv462591 CNV loss 19166990
nsv517697 CNV loss 19592680
nsv600731 CNV loss 21841781
nsv830567 CNV loss 17160897
nsv950745 CNV deletion 24416366

Variation tolerance for TRIM41 Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.09; 80.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM41 Gene

Disorders for TRIM41 Gene

Additional Disease Information for TRIM41

No disorders were found for TRIM41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM41 Gene

Publications for TRIM41 Gene

  1. Intracellular localization and domain organization of human TRIM41 proteins. (PMID: 16022281) Tanaka M … Hanai R (Molecular biology reports 2005) 2 3 4 58
  2. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. (PMID: 17893151) Chen D … Newton AC (The Journal of biological chemistry 2007) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58

Products for TRIM41 Gene

Sources for TRIM41 Gene

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