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Aliases for ZNF598 Gene

Aliases for ZNF598 Gene

  • Zinc Finger Protein 598 2 3 4 5
  • E3 Ubiquitin-Protein Ligase ZNF598 3
  • EC 2.3.2.27 4
  • HEL2 3

External Ids for ZNF598 Gene

Previous GeneCards Identifiers for ZNF598 Gene

  • GC16M001989
  • GC16M001990
  • GC16M002047
  • GC16M001971
  • GC16M001998
  • GC16M002000
  • GC16M002009
  • GC16M002050
  • GC16M002059
  • GC16M002069
  • GC16M002079

Summaries for ZNF598 Gene

Entrez Gene Summary for ZNF598 Gene

  • Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]

GeneCards Summary for ZNF598 Gene

ZNF598 (Zinc Finger Protein 598) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF598 Gene

  • E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931).

Additional gene information for ZNF598 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF598 Gene

Genomics for ZNF598 Gene

GeneHancer (GH) Regulatory Elements for ZNF598 Gene

Promoters and enhancers for ZNF598 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002003 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 680.6 +2.6 2602 7.8 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 ZNF610 ZNF598 NPW CRAMP1 ENSG00000261505 TBL3 ENSG00000255513 SRRM2 ENSG00000260051 SNORA64 TELO2
GH16J001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 54.9 +699.1 699069 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 ENSG00000261505 TELO2 ENSG00000260051 E4F1 TSC2 IFT140
GH16J002147 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.9 -146.0 -145967 17.4 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 TRAF7 SNORD60 SNHG19 ENSG00000281010 GC16M002158 GC16M002156 RAB26 ENSG00000261505 CRAMP1 ENSG00000260051
GH16J002266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 40 -258.4 -258389 3.2 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 RNPS1 ENSG00000260778 GC16M002266 GC16M002267 ZNF263 ENSG00000260051 ENSG00000261505 E4F1 AMDHD2 TSC2
GH16J001962 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 33.7 +45.6 45601 4.1 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000255513 SNORA64 SNHG9 RPS2 GC16M001962 GC16M001963 GC16M001965 GC16P002236 GC16P002239 SNORA10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF598 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF598 gene promoter:
  • AP-1
  • GATA-2
  • Egr-3
  • Nkx2-5
  • AREB6
  • Pax-5
  • Elk-1
  • USF1

Genomic Locations for ZNF598 Gene

Genomic Locations for ZNF598 Gene
chr16:1,997,652-2,009,823
(GRCh38/hg38)
Size:
12,172 bases
Orientation:
Minus strand
chr16:2,047,655-2,059,824
(GRCh37/hg19)
Size:
12,170 bases
Orientation:
Minus strand

Genomic View for ZNF598 Gene

Genes around ZNF598 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF598 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF598 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF598 Gene

Proteins for ZNF598 Gene

  • Protein details for ZNF598 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UK7-ZN598_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ZNF598
    Protein Accession:
    Q86UK7
    Secondary Accessions:
    • Q8IW49
    • Q8N3D9
    • Q96FG3
    • Q9H7J3

    Protein attributes for ZNF598 Gene

    Size:
    904 amino acids
    Molecular mass:
    98637 Da
    Quaternary structure:
    • Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598 (PubMed:22751931).
    SequenceCaution:
    • Sequence=BAB15777.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF598 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF598 Gene

Post-translational modifications for ZNF598 Gene

  • Ubiquitination at posLast=263263
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF598 Gene

No data available for DME Specific Peptides for ZNF598 Gene

Domains & Families for ZNF598 Gene

Gene Families for ZNF598 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF598 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF598 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UK7

UniProtKB/Swiss-Prot:

ZN598_HUMAN :
  • Belongs to the ZNF598 family.
Family:
  • Belongs to the ZNF598 family.
genes like me logo Genes that share domains with ZNF598: view

Function for ZNF598 Gene

Molecular function for ZNF598 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931).
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for ZNF598 Gene

Phenotypes From GWAS Catalog for ZNF598 Gene

Gene Ontology (GO) - Molecular Function for ZNF598 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 28065601
GO:0043022 ribosome binding IDA 28065601
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IMP 28132843
genes like me logo Genes that share ontologies with ZNF598: view
genes like me logo Genes that share phenotypes with ZNF598: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF598

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF598 Gene

Localization for ZNF598 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF598 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF598 Gene

Pathways & Interactions for ZNF598 Gene

SuperPathways for ZNF598 Gene

No Data Available

Interacting Proteins for ZNF598 Gene

Gene Ontology (GO) - Biological Process for ZNF598 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006513 protein monoubiquitination IDA 28065601
GO:0016567 protein ubiquitination IMP 28132843
GO:0072344 rescue of stalled ribosome IMP 28132843
genes like me logo Genes that share ontologies with ZNF598: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF598 Gene

Drugs & Compounds for ZNF598 Gene

No Compound Related Data Available

Transcripts for ZNF598 Gene

mRNA/cDNA for ZNF598 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF598 Gene

Zinc finger protein 598:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF598

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF598 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:
SP8: - -

ExUns: 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ZNF598 Gene

GeneLoc Exon Structure for
ZNF598
ECgene alternative splicing isoforms for
ZNF598

Expression for ZNF598 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF598 Gene

Protein differential expression in normal tissues from HIPED for ZNF598 Gene

This gene is overexpressed in Serum (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF598 Gene



Protein tissue co-expression partners for ZNF598 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF598 Gene:

ZNF598

SOURCE GeneReport for Unigene cluster for ZNF598 Gene:

Hs.343828

Evidence on tissue expression from TISSUES for ZNF598 Gene

  • Lung(4.3)
  • Liver(4.2)
  • Skin(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with ZNF598: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF598 Gene

Orthologs for ZNF598 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF598 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF598 34 33
  • 98.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF598 34 33
  • 83.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF598 34 33
  • 83.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp598 16 34 33
  • 80.81 (n)
rat
(Rattus norvegicus)
Mammalia Zfp598 33
  • 80.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF598 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF598 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF598 34 33
  • 63.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF598 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf598 33
  • 59.17 (n)
Str.10897 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.20891 33
zebrafish
(Danio rerio)
Actinopterygii znf598 34 33
  • 58.39 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11414 34
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C52E12.1 34
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
OneToOne
Species where no ortholog for ZNF598 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF598 Gene

ENSEMBL:
Gene Tree for ZNF598 (if available)
TreeFam:
Gene Tree for ZNF598 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF598: view image

Paralogs for ZNF598 Gene

Pseudogenes.org Pseudogenes for ZNF598 Gene

genes like me logo Genes that share paralogs with ZNF598: view

No data available for Paralogs for ZNF598 Gene

Variants for ZNF598 Gene

Sequence variations from dbSNP and Humsavar for ZNF598 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000226821 -- 2,005,283(-) A/G intron_variant
rs1000291395 -- 2,007,724(-) T/A intron_variant
rs1000472053 -- 2,004,227(-) G/A intron_variant
rs1000600131 -- 2,005,440(-) G/A intron_variant
rs1000697397 -- 2,009,506(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF598 Gene

Variant ID Type Subtype PubMed ID
dgv336n27 CNV loss 19166990
dgv455n67 CNV gain 20364138
dgv4858n54 CNV loss 21841781
dgv4859n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160329 CNV deletion 26073780
nsv457348 CNV loss 19166990
nsv471070 CNV gain 18288195
nsv471072 CNV loss 18288195
nsv521569 CNV loss 19592680
nsv523037 CNV loss 19592680
nsv571189 CNV loss 21841781
nsv952901 CNV deletion 24416366

Variation tolerance for ZNF598 Gene

Gene Damage Index Score: 7.79; 83.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF598 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF598

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF598 Gene

Disorders for ZNF598 Gene

Additional Disease Information for ZNF598

No disorders were found for ZNF598 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF598 Gene

Publications for ZNF598 Gene

  1. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. (PMID: 28685749) Garzia A … Sonenberg N (Nature communications 2017) 2 3 58
  2. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. (PMID: 28065601) Juszkiewicz S … Hegde RS (Molecular cell 2017) 3 4 58
  3. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. (PMID: 28132843) Sundaramoorthy E … Bennett EJ (Molecular cell 2017) 3 4 58
  4. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. (PMID: 22751931) Morita M … Sonenberg N (Molecular and cellular biology 2012) 3 4 58
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58

Products for ZNF598 Gene

Sources for ZNF598 Gene

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