Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSTPIP2 Gene

Aliases for PSTPIP2 Gene

  • Proline-Serine-Threonine Phosphatase Interacting Protein 2 2 3 5
  • PEST Phosphatase-Interacting Protein 2 3 4
  • Proline-Serine-Threonine Phosphatase-Interacting Protein 2 3
  • MAYP 3

External Ids for PSTPIP2 Gene

Previous GeneCards Identifiers for PSTPIP2 Gene

  • GC18M043875
  • GC18M043350
  • GC18M043451
  • GC18M041815
  • GC18M041817
  • GC18M043563
  • GC18M040420

Summaries for PSTPIP2 Gene

GeneCards Summary for PSTPIP2 Gene

PSTPIP2 (Proline-Serine-Threonine Phosphatase Interacting Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is PSTPIP1.

UniProtKB/Swiss-Prot for PSTPIP2 Gene

  • Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).

Gene Wiki entry for PSTPIP2 Gene

Additional gene information for PSTPIP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSTPIP2 Gene

Genomics for PSTPIP2 Gene

GeneHancer (GH) Regulatory Elements for PSTPIP2 Gene

Promoters and enhancers for PSTPIP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J046068 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 656.2 +1.7 1693 4 PKNOX1 ATF1 SIN3A ZNF2 IRF4 ZNF48 GLIS2 ZNF143 ZFP91 RUNX3 PSTPIP2 HAUS1 ATP5F1A LOC100422497
GH18J046073 Enhancer 0.8 ENCODE dbSUPER 650.7 -1.6 -1623 0.2 CTCF ZNF654 TRIM22 REST ZEB2 RAD21 ARID2 GLIS1 SMC3 ZNF143 PSTPIP2 GC18M046078 RNY4P37
GH18J046074 Enhancer 0.7 ENCODE dbSUPER 650.7 -1.4 -1353 0.2 CTCF GLIS1 TRIM22 PRDM10 PSTPIP2 ATP5F1A GC18M046078 RNY4P37
GH18J046096 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.5 -25.6 -25551 2.9 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF207 ZNF143 ATP5F1A GC18P046096 HAUS1 RNY4P37 PSTPIP2 RN7SKP26 EPG5
GH18J046008 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 20.7 +62.8 62809 1.8 RXRA TEAD4 TAL1 CBFA2T3 EP300 RAD21 TCF12 NCOR1 CBFA2T2 HNF4A PSTPIP2 EPG5 RNY4P37 SLC14A2 RN7SKP26 LOC100422497
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSTPIP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSTPIP2 gene promoter:
  • CUTL1
  • POU3F2
  • NF-kappaB1
  • NF-kappaB
  • CREB
  • deltaCREB
  • En-1
  • Max1
  • HEN1
  • Pax-4a

Genomic Locations for PSTPIP2 Gene

Genomic Locations for PSTPIP2 Gene
88,762 bases
Minus strand
88,749 bases
Minus strand

Genomic View for PSTPIP2 Gene

Genes around PSTPIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSTPIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSTPIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSTPIP2 Gene

Proteins for PSTPIP2 Gene

  • Protein details for PSTPIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-serine-threonine phosphatase-interacting protein 2
    Protein Accession:

    Protein attributes for PSTPIP2 Gene

    334 amino acids
    Molecular mass:
    38858 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PSTPIP2 Gene


neXtProt entry for PSTPIP2 Gene

Post-translational modifications for PSTPIP2 Gene

Other Protein References for PSTPIP2 Gene

No data available for DME Specific Peptides for PSTPIP2 Gene

Domains & Families for PSTPIP2 Gene

Gene Families for PSTPIP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSTPIP2 Gene


Suggested Antigen Peptide Sequences for PSTPIP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PSTPIP2: view

No data available for UniProtKB/Swiss-Prot for PSTPIP2 Gene

Function for PSTPIP2 Gene

Molecular function for PSTPIP2 Gene

UniProtKB/Swiss-Prot Function:
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).

Phenotypes From GWAS Catalog for PSTPIP2 Gene

Gene Ontology (GO) - Molecular Function for PSTPIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with PSTPIP2: view
genes like me logo Genes that share phenotypes with PSTPIP2: view

Animal Model Products

CRISPR Products

miRNA for PSTPIP2 Gene

miRTarBase miRNAs that target PSTPIP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSTPIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSTPIP2 Gene

Localization for PSTPIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSTPIP2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSTPIP2 gene
Compartment Confidence
cytosol 4
mitochondrion 3
nucleus 3
plasma membrane 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSTPIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PSTPIP2: view

Pathways & Interactions for PSTPIP2 Gene

SuperPathways for PSTPIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSTPIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0016477 cell migration IEA --
genes like me logo Genes that share ontologies with PSTPIP2: view

No data available for Pathways by source and SIGNOR curated interactions for PSTPIP2 Gene

Drugs & Compounds for PSTPIP2 Gene

No Compound Related Data Available

Transcripts for PSTPIP2 Gene

mRNA/cDNA for PSTPIP2 Gene

Unigene Clusters for PSTPIP2 Gene

Proline-serine-threonine phosphatase interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSTPIP2

Alternative Splicing Database (ASD) splice patterns (SP) for PSTPIP2 Gene

No ASD Table

Relevant External Links for PSTPIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSTPIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSTPIP2 Gene

mRNA differential expression in normal tissues according to GTEx for PSTPIP2 Gene

This gene is overexpressed in Whole Blood (x16.5) and Spleen (x7.5).

Protein differential expression in normal tissues from HIPED for PSTPIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.1), Spleen (16.1), and Platelet (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSTPIP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSTPIP2 Gene:


SOURCE GeneReport for Unigene cluster for PSTPIP2 Gene:


Evidence on tissue expression from TISSUES for PSTPIP2 Gene

  • Blood(2.2)
genes like me logo Genes that share expression patterns with PSTPIP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSTPIP2 Gene

Orthologs for PSTPIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PSTPIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSTPIP2 34 33
  • 99.4 (n)
(Bos Taurus)
Mammalia PSTPIP2 34 33
  • 90.29 (n)
(Canis familiaris)
Mammalia PSTPIP2 34 33
  • 88.34 (n)
(Mus musculus)
Mammalia Pstpip2 16 34 33
  • 85.33 (n)
(Rattus norvegicus)
Mammalia Pstpip2 33
  • 85.03 (n)
(Monodelphis domestica)
Mammalia PSTPIP2 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia PSTPIP2 34
  • 70 (a)
(Gallus gallus)
Aves PSTPIP2 34 33
  • 69.26 (n)
(Anolis carolinensis)
Reptilia PSTPIP2 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pstpip2 33
  • 65.03 (n)
(Danio rerio)
Actinopterygii si:ch211-251f6.4 33
  • 61.87 (n)
CU633857.1 34
  • 57 (a)
PSTPIP2 (1 of 2) 34
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for PSTPIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSTPIP2 Gene

Gene Tree for PSTPIP2 (if available)
Gene Tree for PSTPIP2 (if available)
Evolutionary constrained regions (ECRs) for PSTPIP2: view image

Paralogs for PSTPIP2 Gene

Paralogs for PSTPIP2 Gene

(2) SIMAP similar genes for PSTPIP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSTPIP2: view

Variants for PSTPIP2 Gene

Sequence variations from dbSNP and Humsavar for PSTPIP2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000103549 -- 46,044,891(-) AAAAAA/AAAAAAA genic_upstream_transcript_variant, intron_variant
rs1000136214 -- 46,045,142(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000158153 -- 45,995,235(-) T/C intron_variant
rs1000196703 -- 45,989,485(-) G/A intron_variant
rs1000204799 -- 46,018,546(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSTPIP2 Gene

Variant ID Type Subtype PubMed ID
esv2717027 CNV deletion 23290073
esv2717030 CNV deletion 23290073
esv3642418 CNV gain 21293372
esv3642419 CNV loss 21293372
esv3642420 CNV gain 21293372
esv3642421 CNV loss 21293372
esv3642422 CNV gain 21293372
nsv2277 CNV deletion 18451855
nsv477286 CNV novel sequence insertion 20440878

Variation tolerance for PSTPIP2 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSTPIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSTPIP2 Gene

Disorders for PSTPIP2 Gene

Additional Disease Information for PSTPIP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PSTPIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSTPIP2 Gene

Publications for PSTPIP2 Gene

  1. Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PMID: 20032092) Hurtado-Nedelec M … Gérard B (The Journal of rheumatology 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PMID: 9804817) Wu Y … Lasky LA (The Journal of biological chemistry 1998) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PSTPIP2 Gene

Sources for PSTPIP2 Gene

Loading form....