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Aliases for TM4SF5 Gene

Aliases for TM4SF5 Gene

  • Transmembrane 4 L Six Family Member 5 2 3 5
  • Transmembrane 4 Superfamily Member 5 2 3
  • Tetraspan Transmembrane Protein L6H 3 4
  • Transmembrane 4 L6 Family Member 5 3

External Ids for TM4SF5 Gene

Previous GeneCards Identifiers for TM4SF5 Gene

  • GC17P005102
  • GC17P005020
  • GC17P004625
  • GC17P004881
  • GC17P004621
  • GC17P004675
  • GC17P004563

Summaries for TM4SF5 Gene

Entrez Gene Summary for TM4SF5 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TM4SF5 Gene

TM4SF5 (Transmembrane 4 L Six Family Member 5) is a Protein Coding gene. An important paralog of this gene is TM4SF1.

Gene Wiki entry for TM4SF5 Gene

Additional gene information for TM4SF5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF5 Gene

Genomics for TM4SF5 Gene

GeneHancer (GH) Regulatory Elements for TM4SF5 Gene

Promoters and enhancers for TM4SF5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J004769 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 650.7 -0.6 -587 3.1 FOXA2 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS PAF1 RXRA SP5 TM4SF5 CXCL16 ZNF232 INCA1 ZMYND15 VMO1 ENSG00000262165 ARRB2 SPAG7 MINK1
GH17J004174 Enhancer 0.9 FANTOM5 Ensembl ENCODE 4.5 -594.6 -594559 5.5 ZBTB11 RUNX3 NR2F2 PIR52300 ZZEF1 CYB5D2 ATP2A3 TM4SF5 UBE2G1 P2RX1 NCBP3 PIR35722 GC17M004177
GH17J003777 Enhancer 0.3 dbSUPER 5.8 -994.1 -994081 1.2 NFIC HASPIN NCBP3 TM4SF5 ITGAE ENSG00000262358
GH17J004759 Enhancer 1.2 FANTOM5 ENCODE 0.4 -12.0 -11956 1 ATF1 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 TCF12 ATF7 NFKBIZ VMO1 ZNF232 ZMYND15 SCIMP ARRB2 CXCL16 TM4SF5 GC17M004737
GH17J004764 Enhancer 1 FANTOM5 Ensembl ENCODE 0.4 -6.0 -5983 3.4 CTCF ZNF792 ZSCAN5C CREB1 ATF7 ATF2 SPI1 ZMYND15 CXCL16 ARRB2 C17orf107 VMO1 ENSG00000262165 SCIMP MINK1 SPAG7 TM4SF5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TM4SF5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TM4SF5 gene promoter:
  • NF-kappaB2
  • NF-kappaB1
  • NF-kappaB
  • RelA
  • Evi-1
  • PPAR-alpha
  • LCR-F1
  • NF-1

Genomic Locations for TM4SF5 Gene

Genomic Locations for TM4SF5 Gene
11,330 bases
Plus strand
11,328 bases
Plus strand

Genomic View for TM4SF5 Gene

Genes around TM4SF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF5 Gene

Proteins for TM4SF5 Gene

  • Protein details for TM4SF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 5
    Protein Accession:
    Secondary Accessions:
    • Q17RW9
    • Q6IB79

    Protein attributes for TM4SF5 Gene

    197 amino acids
    Molecular mass:
    20823 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM4SF5 Gene

Post-translational modifications for TM4SF5 Gene

  • Glycosylation at isoforms=155 and isoforms=138

Other Protein References for TM4SF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TM4SF5 Gene

Domains & Families for TM4SF5 Gene

Gene Families for TM4SF5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TM4SF5 Gene


Suggested Antigen Peptide Sequences for TM4SF5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF5: view

Function for TM4SF5 Gene

Molecular function for TM4SF5 Gene

GENATLAS Biochemistry:
transmembrane 4 superfamily,member 5 (tetraspanin family),overexpressed in pancreas cancer,highly homolog to the tumor associated antigen L6

Phenotypes From GWAS Catalog for TM4SF5 Gene

genes like me logo Genes that share phenotypes with TM4SF5: view

Animal Model Products

miRNA for TM4SF5 Gene

miRTarBase miRNAs that target TM4SF5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF5 Gene

Localization for TM4SF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TM4SF5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TM4SF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9479038
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with TM4SF5: view

Pathways & Interactions for TM4SF5 Gene

SuperPathways for TM4SF5 Gene

No Data Available

Interacting Proteins for TM4SF5 Gene

Selected Interacting proteins: O14894-T4S5_HUMAN for TM4SF5 Gene via IID

Gene Ontology (GO) - Biological Process for TM4SF5 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM4SF5 Gene

Drugs & Compounds for TM4SF5 Gene

No Compound Related Data Available

Transcripts for TM4SF5 Gene

mRNA/cDNA for TM4SF5 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TM4SF5 Gene

Transmembrane 4 L six family member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF5 Gene

No ASD Table

Relevant External Links for TM4SF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM4SF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TM4SF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF5 Gene

This gene is overexpressed in Liver (x41.8) and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for TM4SF5 Gene

This gene is overexpressed in Gallbladder (43.5) and Platelet (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TM4SF5 Gene

Protein tissue co-expression partners for TM4SF5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TM4SF5 Gene:


SOURCE GeneReport for Unigene cluster for TM4SF5 Gene:


mRNA Expression by UniProt/SwissProt for TM4SF5 Gene:

Tissue specificity: Intestine. Overexpressed in pancreatic cancers.

Evidence on tissue expression from TISSUES for TM4SF5 Gene

  • Liver(4.5)
genes like me logo Genes that share expression patterns with TM4SF5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TM4SF5 Gene

Orthologs for TM4SF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TM4SF5 34 33
  • 98.48 (n)
(Mus musculus)
Mammalia Tm4sf5 16 34 33
  • 84.01 (n)
(Bos Taurus)
Mammalia TM4SF5 34 33
  • 83.33 (n)
(Canis familiaris)
Mammalia TM4SF5 34 33
  • 82.06 (n)
(Rattus norvegicus)
Mammalia Tm4sf5 33
  • 81.63 (n)
(Monodelphis domestica)
Mammalia TM4SF5 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia TM4SF5 34
  • 60 (a)
(Gallus gallus)
Aves -- 34
  • 39 (a)
(Anolis carolinensis)
Reptilia TM4SF5 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490620 33
  • 66.84 (n)
(Danio rerio)
Actinopterygii tm4sf5 34 33
  • 58.38 (n)
Species where no ortholog for TM4SF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF5 Gene

Gene Tree for TM4SF5 (if available)
Gene Tree for TM4SF5 (if available)
Evolutionary constrained regions (ECRs) for TM4SF5: view image

Paralogs for TM4SF5 Gene

Paralogs for TM4SF5 Gene

(4) SIMAP similar genes for TM4SF5 Gene using alignment to 2 proteins:

  • T4S5_HUMAN
genes like me logo Genes that share paralogs with TM4SF5: view

Variants for TM4SF5 Gene

Sequence variations from dbSNP and Humsavar for TM4SF5 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000053008 -- 4,774,664(+) T/C intron_variant
rs1000193585 -- 4,782,120(+) G/A intron_variant
rs1000270960 -- 4,780,410(+) G/C intron_variant
rs1000476522 -- 4,770,401(+) G/A upstream_transcript_variant
rs1000593828 -- 4,777,055(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF5 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897

Variation tolerance for TM4SF5 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TM4SF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF5 Gene

Disorders for TM4SF5 Gene

Additional Disease Information for TM4SF5

No disorders were found for TM4SF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF5 Gene

Publications for TM4SF5 Gene

  1. Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer. (PMID: 9479038) Müller-Pillasch F … Gress TM (Gene 1998) 2 3 4 22 58
  2. Transmembrane 4 L Six Family Member 5 (TM4SF5)-Mediated Epithelial-Mesenchymal Transition in Liver Diseases. (PMID: 26404468) Lee JW (International review of cell and molecular biology 2015) 2 3 58
  3. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A … EUROSPAN consortium (PLoS genetics 2012) 3 44 58
  4. Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. (PMID: 18357344) Lee SA … Lee JW (The Journal of clinical investigation 2008) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TM4SF5 Gene

Sources for TM4SF5 Gene

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