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Aliases for RAB29 Gene

Aliases for RAB29 Gene

  • RAB29, Member RAS Oncogene Family 2 3 5
  • RAB7, Member RAS Oncogene Family-Like 1 2 3
  • Ras-Related Protein Rab-29 3 4
  • Rab-7-Like Protein 1 3 4
  • RAB7L1 3 4
  • Ras-Related Protein Rab-7L1 3
  • RAB7L 3

External Ids for RAB29 Gene

Previous HGNC Symbols for RAB29 Gene

  • RAB7L
  • RAB7L1

Summaries for RAB29 Gene

GeneCards Summary for RAB29 Gene

RAB29 (RAB29, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RAB geranylgeranylation. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB32.

UniProtKB/Swiss-Prot for RAB29 Gene

  • Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.

Additional gene information for RAB29 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB29 Gene

Genomics for RAB29 Gene

GeneHancer (GH) Regulatory Elements for RAB29 Gene

Promoters and enhancers for RAB29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J205772 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 678.4 +1.0 953 4.7 HDGF CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 SLC30A9 RAB29 LOC105371702 PM20D1 ELK4 NUCKS1
GH01J205747 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE 25 +25.8 25772 4.1 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC NUCKS1 ELK4 EIF2D PM20D1 RAB29 LOC100420878 RPL7AP20 LOC101929459 ENSG00000236108 DSTYK
GH01J205667 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 27.4 +105.1 105138 4.8 HDGF CLOCK FOXA2 ARID4B SIN3A IRF4 ETS1 ZNF143 ATF7 RUNX3 SLC45A3 RAB29 RNU6-418P NUCKS1 ELK4 LOC100420878 MFSD4A CDK18 PM20D1 LOC105371701
GH01J205674 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.6 +97.6 97622 6.3 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A ZNF2 ZNF766 FOS SP3 SLC45A3 PM20D1 RAB29 TMCC2 CDK18 MFSD4A DSTYK LOC105371701 ELK4
GH01J205663 Enhancer 1.3 Ensembl ENCODE dbSUPER 24.9 +109.8 109789 3.4 CLOCK ARID4B SIN3A ZNF48 YY1 ZNF121 FOS RUNX3 RXRA REST RAB29 RNU6-418P NUCKS1 ELK4 LOC100420878 MFSD4A CDK18 SLC45A3 LOC105371701
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB29 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RAB29 Gene

Genomic Locations for RAB29 Gene
chr1:205,767,986-205,775,487
(GRCh38/hg38)
Size:
7,502 bases
Orientation:
Minus strand
chr1:205,737,114-205,744,610
(GRCh37/hg19)
Size:
7,497 bases
Orientation:
Minus strand

Genomic View for RAB29 Gene

Genes around RAB29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB29 Gene

Proteins for RAB29 Gene

  • Protein details for RAB29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14966-RAB7L_HUMAN
    Recommended name:
    Ras-related protein Rab-7L1
    Protein Accession:
    O14966
    Secondary Accessions:
    • B4E1K3
    • C9JE77

    Protein attributes for RAB29 Gene

    Size:
    203 amino acids
    Molecular mass:
    23155 Da
    Quaternary structure:
    • Interacts with LRRK2.

    Alternative splice isoforms for RAB29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB29 Gene

Post-translational modifications for RAB29 Gene

  • In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB29 Gene

Domains & Families for RAB29 Gene

Gene Families for RAB29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAB29 Gene

Graphical View of Domain Structure for InterPro Entry

O14966

UniProtKB/Swiss-Prot:

RAB7L_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB29: view

Function for RAB29 Gene

Molecular function for RAB29 Gene

UniProtKB/Swiss-Prot Function:
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.

Phenotypes From GWAS Catalog for RAB29 Gene

Gene Ontology (GO) - Molecular Function for RAB29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS,IEA --
GO:0005515 protein binding IPI 24510904
GO:0005525 GTP binding IDA 24510904
GO:0017137 Rab GTPase binding IDA 26021297
GO:0019003 GDP binding IDA 24510904
genes like me logo Genes that share ontologies with RAB29: view
genes like me logo Genes that share phenotypes with RAB29: view

Animal Model Products

CRISPR Products

miRNA for RAB29 Gene

miRTarBase miRNAs that target RAB29

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB29

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB29 Gene

Localization for RAB29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB29 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (By similarity). Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847). Colocalizes with TGN46 at the trans-Golgi network (TGN) (PubMed:24788816). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847). {ECO:0000250 UniProtKB:Q63481, ECO:0000269 PubMed:22042847, ECO:0000269 PubMed:24788816}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB29 gene
Compartment Confidence
extracellular 5
mitochondrion 5
golgi apparatus 5
endosome 5
cytosol 4
plasma membrane 3
cytoskeleton 3
nucleus 3
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 24788816
GO:0005739 mitochondrion IDA 25767741
GO:0005769 early endosome IDA 26021297
GO:0005773 vacuole IEA --
GO:0005794 Golgi apparatus IDA 22042847
genes like me logo Genes that share ontologies with RAB29: view

Pathways & Interactions for RAB29 Gene

genes like me logo Genes that share pathways with RAB29: view

Pathways by source for RAB29 Gene

Gene Ontology (GO) - Biological Process for RAB29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IMP 26021297
GO:0006886 intracellular protein transport IBA --
GO:0006888 NOT ER to Golgi vesicle-mediated transport IMP 24788816
GO:0007005 mitochondrion organization IMP 25767741
GO:0007030 Golgi organization IMP 24510904
genes like me logo Genes that share ontologies with RAB29: view

No data available for SIGNOR curated interactions for RAB29 Gene

Drugs & Compounds for RAB29 Gene

No Compound Related Data Available

Transcripts for RAB29 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB29

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB29 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - -
SP10: - -
SP11: - -
SP12: - - - - - - - - - - -
SP13: -
SP14:

Relevant External Links for RAB29 Gene

GeneLoc Exon Structure for
RAB29
ECgene alternative splicing isoforms for
RAB29

Expression for RAB29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB29 Gene

Protein differential expression in normal tissues from HIPED for RAB29 Gene

This gene is overexpressed in Tlymphocyte (18.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB29 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB29 Gene:

RAB29

mRNA Expression by UniProt/SwissProt for RAB29 Gene:

O14966-RAB7L_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RAB29 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with RAB29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB29 Gene

Orthologs for RAB29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAB29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB7L1 34 33
  • 99.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAB7L1 34 33
  • 94.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAB7L1 34 33
  • 91.91 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rab7l1 34 33
  • 90.97 (n)
OneToOne
Rab29 16
rat
(Rattus norvegicus)
Mammalia Rab7l1 33
  • 89.33 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB7L1 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB7L1 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB7L1 34 33
  • 75.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB7L1 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135159 33
  • 68.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32195 33
zebrafish
(Danio rerio)
Actinopterygii si:ch73-173m3.3 34
  • 46 (a)
ManyToMany
Species where no ortholog for RAB29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB29 Gene

ENSEMBL:
Gene Tree for RAB29 (if available)
TreeFam:
Gene Tree for RAB29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB29: view image

Paralogs for RAB29 Gene

Paralogs for RAB29 Gene

genes like me logo Genes that share paralogs with RAB29: view

Variants for RAB29 Gene

Sequence variations from dbSNP and Humsavar for RAB29 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000335662 -- 205,774,301(-) C/A intron_variant
rs1000399272 -- 205,774,495(-) C/T intron_variant
rs1000608558 -- 205,769,070(-) T/G 3_prime_UTR_variant
rs1000673670 -- 205,767,776(-) T/C downstream_transcript_variant
rs1000970962 -- 205,776,157(-) T/C upstream_transcript_variant

Variation tolerance for RAB29 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB29 Gene

Human Gene Mutation Database (HGMD)
RAB29
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB29

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAB29 Gene

Disorders for RAB29 Gene

Additional Disease Information for RAB29

No disorders were found for RAB29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB29 Gene

Publications for RAB29 Gene

  1. Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily. (PMID: 9284931) Shimizu F … Takahashi E (Cytogenetics and cell genetics 1997) 2 3 4 22 58
  2. A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor. (PMID: 24788816) Wang S … Wang T (PloS one 2014) 3 4 58
  3. Thousands of rab GTPases for the cell biologist. (PMID: 22022256) Diekmann Y … Pereira-Leal JB (PLoS computational biology 2011) 2 3 58
  4. Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella. (PMID: 22042847) Spanò S … Galán JE (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RAB29 Gene

Sources for RAB29 Gene

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