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Aliases for AP1M1 Gene

Aliases for AP1M1 Gene

  • Adaptor Related Protein Complex 1 Subunit Mu 1 2 3
  • Adaptor Related Protein Complex 1 Mu 1 Subunit 2 3 5
  • Clathrin Assembly Protein Complex 1 Mu-1 Medium Chain 1 3 4
  • Golgi Adaptor HA1/AP1 Adaptin Mu-1 Subunit 3 4
  • Adaptor Protein Complex AP-1 Subunit Mu-1 3 4
  • Clathrin Coat-Associated Protein AP47 3 4
  • Clathrin Coat Assembly Protein AP47 3 4
  • AP-Mu Chain Family Member Mu1A 3 4
  • Mu-Adaptin 1 3 4
  • Mu1A-Adaptin 3 4
  • CLTNM 3 4
  • Clathrin Assembly Protein Complex 1 Medium Chain 1 3
  • Clathrin Assembly Protein Complex 1, Medium Chain 3
  • Clathrin Assembly Protein Complex AP1, Mu Subunit 3
  • Adaptor-Related Protein Complex 1, Mu 1 Subunit 2
  • Adapter-Related Protein Complex 1 Subunit Mu-1 3
  • Adaptor-Related Protein Complex 1 Subunit Mu-1 4
  • Adaptor Protein Complex AP-1 Mu-1 Subunit 3
  • Golgi Adaptor AP-1 47 KDa Protein 3
  • Clathrin Adaptor Protein AP47 3
  • AP-1 Complex Subunit Mu-1 3
  • HA1 47 KDa Subunit 3
  • CLAPM2 3
  • MU-1A 3
  • AP47 3

External Ids for AP1M1 Gene

Previous GeneCards Identifiers for AP1M1 Gene

  • GC19M016771
  • GC19P016702
  • GC19P016153
  • GC19P016169
  • GC19P016308
  • GC19P015879
  • GC19P016575
  • GC19P016812
  • GC19P017590
  • GC19P018258
  • GC19P018659
  • GC19P018966
  • GC19P019291
  • GC19P019620

Summaries for AP1M1 Gene

Entrez Gene Summary for AP1M1 Gene

  • The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AP1M1 Gene

AP1M1 (Adaptor Related Protein Complex 1 Subunit Mu 1) is a Protein Coding gene. Among its related pathways are E-cadherin signaling in the nascent adherens junction and Clathrin derived vesicle budding. An important paralog of this gene is AP1M2.

UniProtKB/Swiss-Prot for AP1M1 Gene

  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Gene Wiki entry for AP1M1 Gene

Additional gene information for AP1M1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1M1 Gene

Genomics for AP1M1 Gene

GeneHancer (GH) Regulatory Elements for AP1M1 Gene


GeneHancers around AP1M1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AP1M1 gene promoter:
  • POU3F2
  • LUN-1
  • AML1a
  • POU3F1
  • p53
  • ZIC2
  • HOXA5
  • Arnt
  • RFX1

Genomic Locations for AP1M1 Gene

Genomic Locations for AP1M1 Gene
chr19:16,197,578-16,245,907
(GRCh38/hg38)
Size:
48,330 bases
Orientation:
Plus strand
chr19:16,308,389-16,346,160
(GRCh37/hg19)
Size:
37,772 bases
Orientation:
Plus strand

Genomic View for AP1M1 Gene

Genes around AP1M1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1M1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1M1 Gene

Proteins for AP1M1 Gene

  • Protein details for AP1M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXS5-AP1M1_HUMAN
    Recommended name:
    AP-1 complex subunit mu-1
    Protein Accession:
    Q9BXS5
    Secondary Accessions:
    • Q4TTY5

    Protein attributes for AP1M1 Gene

    Size:
    423 amino acids
    Molecular mass:
    48587 Da
    Quaternary structure:
    • Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Interacts with MARCH11 (By similarity). Interacts with HIV-1 Nef. Associates with the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization.

    Alternative splice isoforms for AP1M1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1M1 Gene

Post-translational modifications for AP1M1 Gene

  • Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.
  • Ubiquitination at posLast=346346, Lys333, posLast=229229, and posLast=217217
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AP1M1 Gene

Domains & Families for AP1M1 Gene

Gene Families for AP1M1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for AP1M1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXS5

UniProtKB/Swiss-Prot:

AP1M1_HUMAN :
  • Belongs to the adaptor complexes medium subunit family.
Family:
  • Belongs to the adaptor complexes medium subunit family.
genes like me logo Genes that share domains with AP1M1: view

Function for AP1M1 Gene

Molecular function for AP1M1 Gene

UniProtKB/Swiss-Prot Function:
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Phenotypes From GWAS Catalog for AP1M1 Gene

Gene Ontology (GO) - Molecular Function for AP1M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14691137
genes like me logo Genes that share ontologies with AP1M1: view
genes like me logo Genes that share phenotypes with AP1M1: view

Animal Models for AP1M1 Gene

MGI Knock Outs for AP1M1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AP1M1 Gene

Localization for AP1M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1M1 Gene

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AP1M1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
lysosome 5
golgi apparatus 5
mitochondrion 2
endoplasmic reticulum 2
endosome 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for AP1M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005765 lysosomal membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with AP1M1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AP1M1 Gene

Pathways & Interactions for AP1M1 Gene

genes like me logo Genes that share pathways with AP1M1: view

Pathways by source for AP1M1 Gene

1 GeneGo (Thomson Reuters) pathway for AP1M1 Gene
1 Qiagen pathway for AP1M1 Gene

SIGNOR curated interactions for AP1M1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AP1M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0016032 viral process IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with AP1M1: view

Drugs & Compounds for AP1M1 Gene

No Compound Related Data Available

Transcripts for AP1M1 Gene

mRNA/cDNA for AP1M1 Gene

Unigene Clusters for AP1M1 Gene

Adaptor-related protein complex 1, mu 1 subunit:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP1M1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4: - -
SP5:
SP6:
SP7: -
SP8:

Relevant External Links for AP1M1 Gene

GeneLoc Exon Structure for
AP1M1
ECgene alternative splicing isoforms for
AP1M1

Expression for AP1M1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AP1M1 Gene

Protein differential expression in normal tissues from HIPED for AP1M1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AP1M1 Gene



Protein tissue co-expression partners for AP1M1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AP1M1 Gene:

AP1M1

SOURCE GeneReport for Unigene cluster for AP1M1 Gene:

Hs.71040

Evidence on tissue expression from TISSUES for AP1M1 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Liver(4.3)
  • Kidney(3.4)
  • Lung(3.3)
  • Skin(3.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with AP1M1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AP1M1 Gene

Orthologs for AP1M1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP1M1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP1M1 34 33
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AP1M1 34 33
  • 92.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AP1M1 34 33
  • 92.2 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ap1m1 33
  • 90.31 (n)
oppossum
(Monodelphis domestica)
Mammalia AP1M1 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap1m1 16 34 33
  • 89.2 (n)
chicken
(Gallus gallus)
Aves AP1M1 34 33
  • 79.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP1M1 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ap1m1 33
  • 77.86 (n)
MGC75970 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7449 33
zebrafish
(Danio rerio)
Actinopterygii AP1M1 34
  • 96 (a)
OneToOne
ap1m3 33
  • 72.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011374 33
  • 76.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta AP-47 34 35 33
  • 75.93 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apm-1 34 35
  • 72 (a)
ManyToMany
unc-101 34 35 33
  • 65.64 (n)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL017C 33
  • 60.3 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14311g 33
  • 54.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APM1 36 34 33
  • 54.04 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons HAP13 33
  • 59.03 (n)
rice
(Oryza sativa)
Liliopsida Os01g0703600 33
  • 60.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2288 34
  • 81 (a)
OneToMany
Cin.13831 33
bread mold
(Neurospora crassa)
Ascomycetes NCU09688 33
  • 70.18 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes apm1 33
  • 58.61 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13831 33
Species where no ortholog for AP1M1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AP1M1 Gene

ENSEMBL:
Gene Tree for AP1M1 (if available)
TreeFam:
Gene Tree for AP1M1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AP1M1: view image

Paralogs for AP1M1 Gene

Paralogs for AP1M1 Gene

(7) SIMAP similar genes for AP1M1 Gene using alignment to 9 proteins:

  • AP1M1_HUMAN
  • B4DDG7_HUMAN
  • E7ENJ6_HUMAN
  • K7EJL1_HUMAN
  • K7ENA7_HUMAN
  • K7EPJ8_HUMAN
  • K7EQ90_HUMAN
  • K7EQX3_HUMAN
  • K7ER75_HUMAN
genes like me logo Genes that share paralogs with AP1M1: view

Variants for AP1M1 Gene

Sequence variations from dbSNP and Humsavar for AP1M1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs999036825 A breast cancer sample 16,228,789(+) G/A coding_sequence_variant, missense_variant
rs1000002538 -- 16,215,060(+) C/T intron_variant
rs1000168774 -- 16,222,183(+) T/C intron_variant
rs1000225073 -- 16,208,952(+) C/G intron_variant
rs1000227000 -- 16,219,103(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AP1M1 Gene

Variant ID Type Subtype PubMed ID
esv3643792 CNV gain 21293372
nsv473979 CNV novel sequence insertion 20440878
nsv833767 CNV loss 17160897

Variation tolerance for AP1M1 Gene

Residual Variation Intolerance Score: 15.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AP1M1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AP1M1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP1M1 Gene

Disorders for AP1M1 Gene

Additional Disease Information for AP1M1

No disorders were found for AP1M1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AP1M1 Gene

Publications for AP1M1 Gene

  1. AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin. (PMID: 17988225) Medigeshi GR … Schu P (Traffic (Copenhagen, Denmark) 2008) 2 3 58
  2. The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail. (PMID: 18073204) Wonderlich ER … Collins KL (The Journal of biological chemistry 2008) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). (PMID: 9653655) Peyrard M … Dumanski JP (Genomics 1998) 2 3 58
  5. Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage. (PMID: 28031328) An H … Sun FL (Molecular and cellular biology 2017) 3 58

Products for AP1M1 Gene

Sources for AP1M1 Gene

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