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Aliases for SLC5A6 Gene

Aliases for SLC5A6 Gene

  • Solute Carrier Family 5 Member 6 2 3 4 5
  • Solute Carrier Family 5 (Sodium/Multivitamin And Iodide Cotransporter), Member 6 2 3
  • Solute Carrier Family 5 (Sodium-Dependent Vitamin Transporter), Member 6 2 3
  • Na(+)-Dependent Multivitamin Transporter 3 4
  • SMVT 3 4
  • Sodium-Dependent Multivitamin Transporter 3
  • Na+-Dependent Multivitamin Transporter 3

External Ids for SLC5A6 Gene

Previous GeneCards Identifiers for SLC5A6 Gene

  • GC02M027343
  • GC02M027515
  • GC02M027396
  • GC02M027335
  • GC02M027276
  • GC02M027422

Summaries for SLC5A6 Gene

GeneCards Summary for SLC5A6 Gene

SLC5A6 (Solute Carrier Family 5 Member 6) is a Protein Coding gene. Diseases associated with SLC5A6 include Biotin Deficiency and Thiamine Metabolism Dysfunction Syndrome 2. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity and sodium-dependent multivitamin transmembrane transporter activity. An important paralog of this gene is SLC5A8.

UniProtKB/Swiss-Prot for SLC5A6 Gene

  • Transports pantothenate, biotin and lipoate in the presence of sodium.

Gene Wiki entry for SLC5A6 Gene

Additional gene information for SLC5A6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A6 Gene

Genomics for SLC5A6 Gene

GeneHancer (GH) Regulatory Elements for SLC5A6 Gene

Promoters and enhancers for SLC5A6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I027207 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +2.1 2130 6.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 ATRAID SLC5A6 GTF3C2 SNX17 CAD GPN1 NRBP1 MAPRE3 ENSG00000235267 ENSG00000236099
GH02I027320 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -109.7 -109720 4.2 PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A YBX1 DMAP1 MPV17 PIR47141 ATRAID DNAJC5G SLC30A3 SNX17 ZNF513 SLC5A6 EMILIN1 KHK
GH02I027085 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11 +125.5 125472 4.8 HDGF CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KHK GC02M027085 SNX17 ATRAID GTF3C2 NRBP1 TMEM214 CAD LOC105374363 GPN1
GH02I027031 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.4 +179.8 179795 2.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 ZNF207 GC02M027029 TMEM214 KHK EMILIN1 SLC5A6 ATRAID AGBL5
GH02I027122 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.8 +89.3 89293 1.7 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ATF7 SP3 ABHD1 TCF23 SLC5A6 ATRAID KHK EMILIN1 CAD CENPA SLC35F6 CGREF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC5A6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC5A6 gene promoter:

Genomic Locations for SLC5A6 Gene

Genomic Locations for SLC5A6 Gene
13,372 bases
Minus strand

Genomic View for SLC5A6 Gene

Genes around SLC5A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC5A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC5A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A6 Gene

Proteins for SLC5A6 Gene

  • Protein details for SLC5A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-dependent multivitamin transporter
    Protein Accession:
    Secondary Accessions:
    • B2RB85
    • D6W549
    • Q969Y5

    Protein attributes for SLC5A6 Gene

    635 amino acids
    Molecular mass:
    68642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC5A6 Gene

Post-translational modifications for SLC5A6 Gene

  • Ubiquitination at posLast=579579 and isoforms=599
  • Glycosylation at posLast=138138, isoforms=489, and isoforms=498
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC5A6 Gene

Domains & Families for SLC5A6 Gene

Gene Families for SLC5A6 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for SLC5A6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A6: view

Function for SLC5A6 Gene

Molecular function for SLC5A6 Gene

GENATLAS Biochemistry:
solute carrier family 5,member A6,sodium dependent multivitamin transporter mediating the upstake of pentothenate,biotin,lipoate,expressed in placenta,small intestine,kidney
UniProtKB/Swiss-Prot Function:
Transports pantothenate, biotin and lipoate in the presence of sodium.

Phenotypes From GWAS Catalog for SLC5A6 Gene

Gene Ontology (GO) - Molecular Function for SLC5A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008523 sodium-dependent multivitamin transmembrane transporter activity TAS,IEA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC5A6: view
genes like me logo Genes that share phenotypes with SLC5A6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC5A6

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC5A6 Gene

Localization for SLC5A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC5A6 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC5A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9516450
GO:0012506 vesicle membrane IEA --
GO:0016020 membrane TAS,IEA 9516450
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC5A6: view

Pathways & Interactions for SLC5A6 Gene

genes like me logo Genes that share pathways with SLC5A6: view

Pathways by source for SLC5A6 Gene

Interacting Proteins for SLC5A6 Gene

Gene Ontology (GO) - Biological Process for SLC5A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006768 biotin metabolic process TAS --
GO:0006810 transport IEA,TAS 9516450
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0015878 biotin transport IEA --
genes like me logo Genes that share ontologies with SLC5A6: view

No data available for SIGNOR curated interactions for SLC5A6 Gene

Drugs & Compounds for SLC5A6 Gene

(17) Drugs for SLC5A6 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Biotin Approved, Investigational Nutra Target 53
Gabapentin enacarbil Approved, Investigational Pharma Transporter, substrate 0
Lipoic Acid Approved, Investigational Nutra Target 0

(14) Additional Compounds for SLC5A6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
(S)-lipoic acid
  • (S)-(−)-lipoic acid
  • (S)-1,2-dithiolane-3-pentanoic acid
  • (S)-alpha-lipoic acid
  • L-1,2-dithiolane 3-valeric acid
  • L-6,8-thioctic acid
genes like me logo Genes that share compounds with SLC5A6: view

Transcripts for SLC5A6 Gene

Unigene Clusters for SLC5A6 Gene

Solute carrier family 5 (sodium-dependent vitamin transporter), member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: -
SP12: - -
SP13: - - - - - - - - -
SP14: - - - -
SP15: -

ExUns: 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: -

Relevant External Links for SLC5A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC5A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC5A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC5A6 Gene

This gene is overexpressed in Liver (x10.4).

Protein differential expression in normal tissues from HIPED for SLC5A6 Gene

This gene is overexpressed in Bone (24.1), Cerebral cortex (18.5), Placenta (17.6), and Liver (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC5A6 Gene

Protein tissue co-expression partners for SLC5A6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC5A6 Gene:


SOURCE GeneReport for Unigene cluster for SLC5A6 Gene:


Evidence on tissue expression from TISSUES for SLC5A6 Gene

  • Nervous system(4.7)
  • Intestine(4.5)
  • Stomach(3.8)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with SLC5A6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC5A6 Gene

Orthologs for SLC5A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC5A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC5A6 33 34
  • 99.37 (n)
(Bos Taurus)
Mammalia SLC5A6 33 34
  • 86.14 (n)
(Canis familiaris)
Mammalia SLC5A6 33 34
  • 85.86 (n)
(Rattus norvegicus)
Mammalia Slc5a6 33
  • 83.41 (n)
(Mus musculus)
Mammalia Slc5a6 33 16 34
  • 83.15 (n)
(Monodelphis domestica)
Mammalia SLC5A6 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia SLC5A6 34
  • 70 (a)
(Gallus gallus)
Aves SLC5A6 34
  • 77 (a)
(Anolis carolinensis)
Reptilia SLC5A6 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc5a6 33
  • 71.55 (n)
(Danio rerio)
Actinopterygii SLC5A6 (2 of 2) 34
  • 65 (a)
si:dkey-5g7.3 33
  • 64.45 (n)
slc5a6 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10444 35 34
  • 40 (a)
CG32669 34
  • 35 (a)
CG6723 35
  • 33 (a)
CG8934 35
  • 33 (a)
CG8966 35
  • 33 (a)
CG2187 35
  • 32 (a)
CG2191 35
  • 32 (a)
CG8451 35
  • 32 (a)
CG2196 35
  • 31 (a)
CG5687 35
  • 31 (a)
CG9657 35
  • 30 (a)
CG7720 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea ZK822.5 35
  • 31 (a)
F52H2.4 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for SLC5A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC5A6 Gene

Gene Tree for SLC5A6 (if available)
Gene Tree for SLC5A6 (if available)

Paralogs for SLC5A6 Gene

genes like me logo Genes that share paralogs with SLC5A6: view

Variants for SLC5A6 Gene

Sequence variations from dbSNP and Humsavar for SLC5A6 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000109313 -- 27,211,259(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000137796 -- 27,203,568(-) A/C intron_variant
rs1000701977 -- 27,203,463(-) C/G intron_variant
rs1001218868 -- 27,203,720(-) C/A intron_variant
rs1001319698 -- 27,204,699(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC5A6 Gene

Variant ID Type Subtype PubMed ID
nsv833603 CNV loss 17160897

Variation tolerance for SLC5A6 Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC5A6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A6 Gene

Disorders for SLC5A6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC5A6 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
biotin deficiency
  • b7 deficiency
thiamine metabolism dysfunction syndrome 2
  • thmd2
urinary tract obstruction
  • obstructive uropathy
basal ganglia disease
  • basal ganglia diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC5A6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC5A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC5A6 Gene

Publications for SLC5A6 Gene

  1. Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. (PMID: 10329687) Wang H … Prasad PD (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo. (PMID: 17135299) Reidling JC … Said HM (American journal of physiology. Cell physiology 2007) 3 22 25 58
  3. Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. (PMID: 16749865) Luo S … Mitra AK (Molecular pharmaceutics 2006) 3 22 25 58
  4. Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT. (PMID: 11955628) Dey S … Said HM (Biochimica et biophysica acta 2002) 3 22 25 58
  5. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. (PMID: 10334869) Prasad PD … Ganapathy V (Archives of biochemistry and biophysics 1999) 3 4 25 58

Products for SLC5A6 Gene

Sources for SLC5A6 Gene

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