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Aliases for CCK Gene

Aliases for CCK Gene

  • Cholecystokinin 2 3 3 5
  • Cholecystokinin Triacontatriapeptide 2 3
  • Prepro-Cholecystokinin 2 3

External Ids for CCK Gene

Previous GeneCards Identifiers for CCK Gene

  • GC03P041561
  • GC03U900036
  • GC03M9D0028

Summaries for CCK Gene

Entrez Gene Summary for CCK Gene

  • This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

GeneCards Summary for CCK Gene

CCK (Cholecystokinin) is a Protein Coding gene. Diseases associated with CCK include Biliary Dyskinesia and Cholecystitis. Among its related pathways are Cell-type Dependent Selectivity of CCK2R Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CCK Gene

  • This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

Tocris Summary for CCK Gene

  • Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin. The CCK1 receptor has a high affinity for sulfated CCK analogs, whereas the CCK2 receptor has similar affinity for sulfated and non-sulfated forms.

Gene Wiki entry for CCK Gene

Additional gene information for CCK Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCK Gene

Genomics for CCK Gene

GeneHancer (GH) Regulatory Elements for CCK Gene

Promoters and enhancers for CCK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J042264 Promoter 0.9 EPDnew 650.7 +1.4 1424 0.1 KLF1 SP3 L3MBTL2 KLF17 MNT REST EGR1 FOXP2 MGA ENSG00000281160 CCK LOC105377048
GH03J042368 Enhancer 0.7 FANTOM5 ENCODE 19.9 -103.1 -103082 1.6 SP1 RFX1 BMI1 CCK LYZL4 HHATL TRAK1 EIF4BP4
GH03J042682 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.3 -418.9 -418932 5 ATF1 FOXA2 ARNT INSM2 ETS1 EGR1 FOS CREM SMARCA5 ZNF362 KLHL40 SEC22C HHATL LYZL4 NKTR CCDC13 CCK KRBOX1 RN7SL567P
GH03J042098 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.2 +166.8 166785 2.2 HDGF ARNT ARID4B SIN3A BRCA1 ZNF48 ARID2 ZNF143 ZFP91 ATF7 TRAK1 ENSG00000212145 ULK4 CCK GC03P042123 ENSG00000229339
GH03J042229 Enhancer 0.5 Ensembl 10.6 +36.3 36306 0.2 CTCF GATA3 ZNF654 RXRA IKZF1 REST RAD21 CCK VIPR1 VIPR1-AS1 RNU4-78P LOC105377048
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCK gene promoter:
  • STAT1
  • AP-1
  • STAT3
  • CREB
  • deltaCREB
  • ATF-2
  • c-Jun
  • c-Fos

Genomic Locations for CCK Gene

Genomic Locations for CCK Gene
8,383 bases
Minus strand
8,383 bases
Minus strand

Genomic View for CCK Gene

Genes around CCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCK Gene

Proteins for CCK Gene

  • Protein details for CCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for CCK Gene

    115 amino acids
    Molecular mass:
    12669 Da
    Quaternary structure:
    • Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.

neXtProt entry for CCK Gene

Post-translational modifications for CCK Gene

  • The precursor is cleaved by proteases to produce a number of active cholecystokinins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCK Gene

Antibody Products

No data available for DME Specific Peptides for CCK Gene

Domains & Families for CCK Gene

Gene Families for CCK Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CCK Gene

Suggested Antigen Peptide Sequences for CCK Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the gastrin/cholecystokinin family.
  • Belongs to the gastrin/cholecystokinin family.
genes like me logo Genes that share domains with CCK: view

Function for CCK Gene

Molecular function for CCK Gene

UniProtKB/Swiss-Prot Function:
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
GENATLAS Biochemistry:

Phenotypes From GWAS Catalog for CCK Gene

Gene Ontology (GO) - Molecular Function for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 10320330
GO:0005184 neuropeptide hormone activity ISS 15374756
genes like me logo Genes that share ontologies with CCK: view
genes like me logo Genes that share phenotypes with CCK: view

Animal Models for CCK Gene

MGI Knock Outs for CCK:
  • Cck Cck<tm1Lcs>
  • Cck Cck<tm1Dgen>
  • Cck Cck<tm2b(EUCOMM)Hmgu>

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCK Gene

Localization for CCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCK Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCK gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0030424 axon ISS 15152034
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CCK: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCK Gene

Pathways & Interactions for CCK Gene

genes like me logo Genes that share pathways with CCK: view

SIGNOR curated interactions for CCK Gene


Gene Ontology (GO) - Biological Process for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0001764 neuron migration ISS 15152034
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
genes like me logo Genes that share ontologies with CCK: view

Drugs & Compounds for CCK Gene

(111) Drugs for CCK Gene - From: ClinicalTrials, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxine Approved, Investigational, Vet_approved Nutra 198,198
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 594
Caffeine Approved Nutra Antagonist, Activator 434
Cholecystokinin Approved, Investigational Pharma 21
Esomeprazole Approved, Investigational Pharma Proton pump inhibitor 350

(72) Additional Compounds for CCK Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CCK Octapeptide, sulfated

(3) Tocris Compounds for CCK Gene

Compound Action Cas Number
CCK Octapeptide, non-sulfated Non-sulfated form of CCK octapeptide 25679-24-7
CCK Octapeptide, sulfated C-terminal octapeptide of CCK 25126-32-3
Proglumide sodium salt Non-selective CCK antagonist; orally active 99247-33-3
genes like me logo Genes that share compounds with CCK: view

Drug Products

Transcripts for CCK Gene

mRNA/cDNA for CCK Gene

Unigene Clusters for CCK Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCK Gene

No ASD Table

Relevant External Links for CCK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCK Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x12.0), Brain - Cortex (x10.9), Brain - Anterior cingulate cortex (BA24) (x10.6), Brain - Amygdala (x7.3), and Brain - Hippocampus (x5.4).

Protein differential expression in normal tissues from HIPED for CCK Gene

This gene is overexpressed in Frontal cortex (49.9) and Brain (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCK Gene

Protein tissue co-expression partners for CCK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCK Gene:


SOURCE GeneReport for Unigene cluster for CCK Gene:


Evidence on tissue expression from TISSUES for CCK Gene

  • Pancreas(4.7)
  • Nervous system(4.5)
  • Gall bladder(3.9)
  • Intestine(3.9)
  • Stomach(3.5)
  • Blood(3)
  • Muscle(2.6)
  • Liver(2.3)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with CCK: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCK Gene

Orthologs for CCK Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCK 34 33
  • 99.71 (n)
(Canis familiaris)
Mammalia CCK 34 33
  • 88.6 (n)
(Bos Taurus)
Mammalia CCK 34 33
  • 85.51 (n)
(Mus musculus)
Mammalia Cck 16 34 33
  • 82.9 (n)
(Rattus norvegicus)
Mammalia Cck 33
  • 81.45 (n)
(Monodelphis domestica)
Mammalia CCK 34
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia CCK 34
  • 39 (a)
(Gallus gallus)
Aves CCK 34 33
  • 66.96 (n)
(Anolis carolinensis)
Reptilia CCK 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497815 33
  • 55.65 (n)
(Danio rerio)
Actinopterygii CCK (1 of 2) 34
  • 38 (a)
cck 34
  • 35 (a)
Species where no ortholog for CCK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCK Gene

Gene Tree for CCK (if available)
Gene Tree for CCK (if available)
Evolutionary constrained regions (ECRs) for CCK: view image

Paralogs for CCK Gene

No data available for Paralogs for CCK Gene

Variants for CCK Gene

Sequence variations from dbSNP and Humsavar for CCK Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000102664 -- 42,260,943(-) T/C intron_variant
rs1000116399 -- 42,266,000(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000275274 -- 42,265,792(-) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000537790 -- 42,258,847(-) T/C intron_variant
rs1000549312 -- 42,259,075(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCK Gene

Variant ID Type Subtype PubMed ID
nsv1073220 CNV deletion 25765185
nsv1112823 CNV deletion 24896259
nsv590147 CNV loss 21841781
nsv834671 CNV gain 17160897
nsv954470 CNV deletion 24416366

Variation tolerance for CCK Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCK Gene

Disorders for CCK Gene

MalaCards: The human disease database

(67) MalaCards diseases for CCK Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
biliary dyskinesia
  • sphincter of oddi dysfunction
  • acute and chronic cholecystitis
acalculous cholecystitis
  • acute acalculous cholecystitis
bile reflux
- elite association - COSMIC cancer census association via MalaCards
Search CCK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCK

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCK Gene

Publications for CCK Gene

  1. Polymorphisms of the cholecystokinin gene promoter region in suicide victims in Japan. (PMID: 15837012) Shindo S … Yoshioka N (Forensic science international 2005) 3 22 44 58
  2. Cholecystokinin (CCK) and the CCKA receptor gene polymorphism, and smoking behavior. (PMID: 15740988) Takimoto T … Iwahashi K (Psychiatry research 2005) 3 22 44 58
  3. Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. (PMID: 12777967) Wang J … Yu L (Pharmacogenetics 2003) 3 22 44 58
  4. Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PMID: 12198366) Okubo T … Matsushita S (Alcoholism, clinical and experimental research 2002) 3 22 44 58
  5. Association studies of the CT repeat polymorphism in the 5' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects. (PMID: 11803530) Hattori E … Yoshikawa T (American journal of medical genetics 2001) 3 22 44 58

Products for CCK Gene

Sources for CCK Gene

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