Aliases for CREG1 Gene
Previous HGNC Symbols for CREG1 Gene
Previous GeneCards Identifiers for CREG1 Gene
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for CREG1 Gene
CREG1 (Cellular Repressor Of E1A Stimulated Genes 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and transcription corepressor activity. An important paralog of this gene is CREG2.
UniProtKB/Swiss-Prot for CREG1 Gene
May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.