Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS11 Gene

Aliases for RGS11 Gene

  • Regulator Of G Protein Signaling 11 2 3 5
  • Regulator Of G-Protein Signalling 11 2 3
  • Regulator Of G-Protein Signaling 11 2 3
  • RS11 3

External Ids for RGS11 Gene

Previous GeneCards Identifiers for RGS11 Gene

  • GC16M000337
  • GC16M000259
  • GC16M000260
  • GC16M000261
  • GC16M000318

Summaries for RGS11 Gene

Entrez Gene Summary for RGS11 Gene

  • The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

GeneCards Summary for RGS11 Gene

RGS11 (Regulator Of G Protein Signaling 11) is a Protein Coding gene. Diseases associated with RGS11 include Retinoschisis 1, X-Linked, Juvenile and Congenital Stationary Night Blindness. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and G-protein beta-subunit binding. An important paralog of this gene is RGS9.

UniProtKB/Swiss-Prot for RGS11 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Gene Wiki entry for RGS11 Gene

Additional gene information for RGS11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS11 Gene

Genomics for RGS11 Gene

GeneHancer (GH) Regulatory Elements for RGS11 Gene

Promoters and enhancers for RGS11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000275 Promoter/Enhancer 1.4 EPDnew Ensembl dbSUPER 670.7 +0.1 79 0.6 ZBTB33 EZH2 RGS11 GC16M000275 GC16P000448 GC16M000274 TMEM8A ARHGDIG
GH16J000276 Enhancer 0.6 ENCODE dbSUPER 650.7 +0.6 624 0.2 SIN3A ZBTB33 EZH2 GC16M000275 RGS11 GC16M000274 ARHGDIG
GH16J000635 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 -361.1 -361092 4.1 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 ZNF610 METTL26 MCRIP2 TRG-CCC2-2 GC16P001015 LOC100287175 WFIKKN1 WDR90 CRAMP1 JMJD8 TELO2
GH16J000739 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 -464.8 -464751 1.9 PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CIAO3 UBE2I WDR90 ENSG00000261505 TELO2 UNKL CRAMP1 WASH4P ENSG00000268836 ENSG00000260051
GH16J000233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.6 +41.0 41031 2.9 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 ZNF610 GLIS1 FAM234A WDR90 LUC7L RHOT2 ENSG00000268836 JMJD8 WASH4P ENSG00000228779 WDR24 LMF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS11 gene promoter:
  • AP-2gamma
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha
  • COMP1
  • Lmo2
  • CBF(2)
  • NF-Y
  • Evi-1

Genomic Locations for RGS11 Gene

Genomic Locations for RGS11 Gene
7,680 bases
Minus strand
7,681 bases
Minus strand

Genomic View for RGS11 Gene

Genes around RGS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS11 Gene

Proteins for RGS11 Gene

  • Protein details for RGS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 11
    Protein Accession:
    Secondary Accessions:
    • O75883
    • Q4TT71
    • Q4TT72

    Protein attributes for RGS11 Gene

    467 amino acids
    Molecular mass:
    52946 Da
    Quaternary structure:
    • Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).

    Alternative splice isoforms for RGS11 Gene


neXtProt entry for RGS11 Gene

Post-translational modifications for RGS11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS11 Gene

Domains & Families for RGS11 Gene

Gene Families for RGS11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS11: view

No data available for UniProtKB/Swiss-Prot for RGS11 Gene

Function for RGS11 Gene

Molecular function for RGS11 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
GENATLAS Biochemistry:
negative regulator of G protein signaling 11,predominantly expressed in both brain and retina,functioning as GTPase-activating protein for G protein alpha subunits,G alpha i, G alpha o and complexing with G beta 5

Phenotypes From GWAS Catalog for RGS11 Gene

Gene Ontology (GO) - Molecular Function for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS 9789084
GO:0031681 G-protein beta-subunit binding IPI 12606627
genes like me logo Genes that share ontologies with RGS11: view
genes like me logo Genes that share phenotypes with RGS11: view

Animal Models for RGS11 Gene

MGI Knock Outs for RGS11:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS11

Clone Products

  • Addgene plasmids for RGS11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS11 Gene

Localization for RGS11 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS11 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane IBA --
GO:0032991 protein-containing complex IDA 18468998
genes like me logo Genes that share ontologies with RGS11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RGS11 Gene

Pathways & Interactions for RGS11 Gene

genes like me logo Genes that share pathways with RGS11: view

Gene Ontology (GO) - Biological Process for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 9789084
GO:0009968 negative regulation of signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS11: view

No data available for SIGNOR curated interactions for RGS11 Gene

Drugs & Compounds for RGS11 Gene

No Compound Related Data Available

Transcripts for RGS11 Gene

Unigene Clusters for RGS11 Gene

Regulator of G-protein signaling 11:
Representative Sequences:

Clone Products

  • Addgene plasmids for RGS11

Alternative Splicing Database (ASD) splice patterns (SP) for RGS11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - - -
SP3: - -
SP5: -

Relevant External Links for RGS11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS11 Gene

This gene is overexpressed in Brain - Cerebellum (x8.3) and Brain - Cerebellar Hemisphere (x6.8).

NURSA nuclear receptor signaling pathways regulating expression of RGS11 Gene:


SOURCE GeneReport for Unigene cluster for RGS11 Gene:


Evidence on tissue expression from TISSUES for RGS11 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with RGS11: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS11 Gene

Orthologs for RGS11 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS11 34 33
  • 93.76 (n)
(Bos Taurus)
Mammalia RGS11 34 33
  • 83.88 (n)
(Rattus norvegicus)
Mammalia Rgs11 33
  • 82.59 (n)
(Mus musculus)
Mammalia Rgs11 16 34 33
  • 81.89 (n)
(Canis familiaris)
Mammalia RGS11 34 33
  • 81.32 (n)
(Ornithorhynchus anatinus)
Mammalia RGS11 34
  • 69 (a)
(Monodelphis domestica)
Mammalia RGS11 34
  • 69 (a)
(Gallus gallus)
Aves RGS11 33
  • 75.68 (n)
-- 34
  • 71 (a)
-- 34
  • 68 (a)
(Anolis carolinensis)
Reptilia RGS11 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs9 33
  • 69.66 (n)
(Danio rerio)
Actinopterygii rgs11 34 33
  • 65.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000232 33
  • 54.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7095 35
  • 41 (a)
CG42450 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea eat-16 34
  • 30 (a)
Species where no ortholog for RGS11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS11 Gene

Gene Tree for RGS11 (if available)
Gene Tree for RGS11 (if available)
Evolutionary constrained regions (ECRs) for RGS11: view image

Paralogs for RGS11 Gene

Paralogs for RGS11 Gene

(14) SIMAP similar genes for RGS11 Gene using alignment to 7 proteins:

  • B7Z1X0_HUMAN
  • B7Z285_HUMAN
  • H7C5Z0_HUMAN
  • Q4TT70_HUMAN
genes like me logo Genes that share paralogs with RGS11: view

Variants for RGS11 Gene

Sequence variations from dbSNP and Humsavar for RGS11 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000133880 -- 272,853(-) A/G intron_variant, non_coding_transcript_variant
rs1000299354 -- 268,363(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000389084 -- 275,558(-) C/T intron_variant
rs1000734465 -- 273,634(-) G/A intron_variant
rs1000767682 -- 271,747(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS11 Gene

Variant ID Type Subtype PubMed ID
dgv1479e59 CNV duplication 20981092
dgv32n68 CNV loss 17160897
esv2422427 CNV duplication 17116639
esv3570031 CNV gain 25503493
esv3637561 CNV loss 21293372
esv3637562 CNV gain 21293372
esv3637563 CNV gain 21293372
nsv570947 CNV loss 21841781
nsv827477 CNV gain 20364138
nsv952896 CNV deletion 24416366

Variation tolerance for RGS11 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.01; 90.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS11 Gene

Disorders for RGS11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RGS11 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
retinoschisis 1, x-linked, juvenile
  • rs1
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards
Search RGS11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGS11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RGS11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS11 Gene

Publications for RGS11 Gene

  1. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. (PMID: 9789084) Snow BE … Siderovski DP (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  3. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 44 58
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 58

Products for RGS11 Gene

Sources for RGS11 Gene

Loading form....