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Aliases for UNC5C Gene

Aliases for UNC5C Gene

  • Unc-5 Netrin Receptor C 2 3 5
  • Unc5 (C.Elegans Homolog) C 2 3
  • Protein Unc-5 Homolog 3 3 4
  • Protein Unc-5 Homolog C 3 4
  • UNC5H3 3 4
  • Unc-5 Homolog C (C. Elegans) 2
  • Netrin Receptor UNC5C 3
  • Unc-5 Homolog 3 3
  • Unc-5 Homolog C 3

External Ids for UNC5C Gene

Previous GeneCards Identifiers for UNC5C Gene

  • GC04M096436
  • GC04M096548
  • GC04M096446
  • GC04M096308
  • GC04M096083
  • GC04M091820

Summaries for UNC5C Gene

Entrez Gene Summary for UNC5C Gene

  • This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

GeneCards Summary for UNC5C Gene

UNC5C (Unc-5 Netrin Receptor C) is a Protein Coding gene. Among its related pathways are Developmental Biology and Guidance Cues and Growth Cone Motility. Gene Ontology (GO) annotations related to this gene include netrin receptor activity. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot for UNC5C Gene

  • Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Gene Wiki entry for UNC5C Gene

Additional gene information for UNC5C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5C Gene

Genomics for UNC5C Gene

GeneHancer (GH) Regulatory Elements for UNC5C Gene

Promoters and enhancers for UNC5C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J095547 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.5 483 4.2 PKNOX1 KLF17 MZF1 FEZF1 BATF ZNF2 IRF4 ZNF335 GLIS2 ZNF366 LOC105377335 UNC5C GC04P095538
GH04J095290 Enhancer 0.6 dbSUPER 5.8 +258.1 258079 1.7 CBFA2T3 PYGO2 EBF1 ELF1 ZNF592 IKZF1 RUNX3 IKZF2 EZH2 UNC5C GC04M095360 PIR50489 GC04P095189
GH04J095262 Enhancer 0.4 dbSUPER 5.3 +285.0 285000 2.5 USF1 ZNF184 ZBTB20 UNC5C GC04P095189 PIR50489 GC04M095360
GH04J095401 Enhancer 0.3 dbSUPER 6.6 +146.7 146651 2 MAFK UNC5C GC04M095360 GC04P095538
GH04J095314 Enhancer 0.4 dbSUPER 4.6 +231.1 231062 6.3 POLR2A RCOR1 CHD2 UNC5C GC04M095360 GC04P095189 PIR50489
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UNC5C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UNC5C gene promoter:
  • TBP
  • RORalpha1
  • Lmo2
  • Zic1
  • POU2F1a
  • POU2F1
  • c-Fos
  • AP-1
  • FosB

Genomic Locations for UNC5C Gene

Genomic Locations for UNC5C Gene
386,707 bases
Minus strand
386,707 bases
Minus strand

Genomic View for UNC5C Gene

Genes around UNC5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5C Gene

Proteins for UNC5C Gene

  • Protein details for UNC5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Netrin receptor UNC5C
    Protein Accession:
    Secondary Accessions:
    • Q8IUT0

    Protein attributes for UNC5C Gene

    931 amino acids
    Molecular mass:
    103146 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DCC. Interacts (tyrosine phosphorylated form) with PTPN11. Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (By similarity).
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

    Alternative splice isoforms for UNC5C Gene


neXtProt entry for UNC5C Gene

Post-translational modifications for UNC5C Gene

  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent.
  • Glycosylation at isoforms=2361 and posLast=236236
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UNC5C Gene

Domains & Families for UNC5C Gene

Gene Families for UNC5C Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for UNC5C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the unc-5 family.
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5C: view

Function for UNC5C Gene

Molecular function for UNC5C Gene

UniProtKB/Swiss-Prot Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
GENATLAS Biochemistry:
C elegans Unc5 and murine unc5hr homolog,involved in cell migration during cerebellum development,inducing repulsion in axon guidance through its cytoplasmic tail,expressed in brain,fetal heart

Phenotypes From GWAS Catalog for UNC5C Gene

Gene Ontology (GO) - Molecular Function for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005042 netrin receptor activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with UNC5C: view
genes like me logo Genes that share phenotypes with UNC5C: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC5C Gene

Localization for UNC5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5C Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC5C gene
Compartment Confidence
plasma membrane 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with UNC5C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UNC5C Gene

Pathways & Interactions for UNC5C Gene

genes like me logo Genes that share pathways with UNC5C: view

Pathways by source for UNC5C Gene

1 KEGG pathway for UNC5C Gene
2 Qiagen pathways for UNC5C Gene

SIGNOR curated interactions for UNC5C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0007411 axon guidance TAS 9126742
GO:0007420 brain development TAS,IEA --
genes like me logo Genes that share ontologies with UNC5C: view

Drugs & Compounds for UNC5C Gene

No Compound Related Data Available

Transcripts for UNC5C Gene

mRNA/cDNA for UNC5C Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UNC5C Gene

Unc-5 homolog C (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - -
SP2: -

Relevant External Links for UNC5C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNC5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNC5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC5C Gene

This gene is overexpressed in Adrenal (47.2) and Fetal Brain (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UNC5C Gene

Protein tissue co-expression partners for UNC5C Gene

NURSA nuclear receptor signaling pathways regulating expression of UNC5C Gene:


SOURCE GeneReport for Unigene cluster for UNC5C Gene:


mRNA Expression by UniProt/SwissProt for UNC5C Gene:

Tissue specificity: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.

Evidence on tissue expression from TISSUES for UNC5C Gene

  • Nervous system(4.8)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with UNC5C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC5C Gene

Orthologs for UNC5C Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UNC5C 34 33
  • 99.5 (n)
(Monodelphis domestica)
Mammalia UNC5C 34
  • 95 (a)
(Canis familiaris)
Mammalia UNC5C 34 33
  • 91.69 (n)
(Bos Taurus)
Mammalia UNC5C 34 33
  • 91.43 (n)
(Mus musculus)
Mammalia Unc5c 16 34 33
  • 89.65 (n)
(Rattus norvegicus)
Mammalia Unc5c 33
  • 88.97 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
-- 34
  • 88 (a)
(Gallus gallus)
Aves UNC5C 34 33
  • 82.46 (n)
(Anolis carolinensis)
Reptilia UNC5C 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5c 33
  • 77.62 (n)
(Danio rerio)
Actinopterygii unc5c 34 33
  • 72.35 (n)
UNC5C (1 of 2) 34
  • 64 (a)
Dr.14572 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009061 33
  • 45.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta unc-5 35 33
  • 44.27 (n)
(Caenorhabditis elegans)
Secernentea unc-5 35
  • 28 (a)
Species where no ortholog for UNC5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC5C Gene

Gene Tree for UNC5C (if available)
Gene Tree for UNC5C (if available)
Evolutionary constrained regions (ECRs) for UNC5C: view image

Paralogs for UNC5C Gene

Paralogs for UNC5C Gene

(4) SIMAP similar genes for UNC5C Gene using alignment to 4 proteins:

  • D6RE16_HUMAN
  • E0CX15_HUMAN
  • Q4W5H4_HUMAN
genes like me logo Genes that share paralogs with UNC5C: view

Variants for UNC5C Gene

Sequence variations from dbSNP and Humsavar for UNC5C Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000013222 -- 95,461,268(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000016193 -- 95,405,261(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000023589 -- 95,183,988(-) A/G intron_variant
rs10000289 -- 95,516,455(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000032038 -- 95,370,177(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5C Gene

Variant ID Type Subtype PubMed ID
dgv2856n106 CNV deletion 24896259
dgv9175n54 CNV loss 21841781
dgv9176n54 CNV loss 21841781
esv1001867 CNV deletion 20482838
esv1143724 CNV insertion 17803354
esv1227332 CNV deletion 17803354
esv1489767 CNV insertion 17803354
esv1617018 CNV insertion 17803354
esv2041389 CNV deletion 18987734
esv25475 CNV loss 19812545
esv2577861 CNV deletion 19546169
esv2660811 CNV deletion 23128226
esv2661832 CNV deletion 23128226
esv2674923 CNV deletion 23128226
esv27157 CNV loss 19812545
esv2727993 CNV deletion 23290073
esv2727994 CNV deletion 23290073
esv2727996 CNV deletion 23290073
esv2763844 CNV loss 21179565
esv2808 CNV loss 18987735
esv3450367 CNV duplication 20981092
esv3564287 CNV deletion 23714750
esv3564288 CNV deletion 23714750
esv3564289 CNV deletion 23714750
esv3569613 CNV loss 25503493
esv3569614 CNV loss 25503493
esv3601464 CNV loss 21293372
esv3601466 CNV loss 21293372
nsv1005881 CNV gain 25217958
nsv1074200 CNV deletion 25765185
nsv1133345 CNV tandem duplication 24896259
nsv1151405 CNV deletion 26484159
nsv471768 CNV loss 16327809
nsv478904 CNV novel sequence insertion 20440878
nsv519986 CNV loss 19592680
nsv521417 CNV loss 19592680
nsv523039 CNV loss 19592680
nsv525953 CNV loss 19592680
nsv527705 CNV loss 19592680
nsv594907 CNV gain 21841781
nsv822655 CNV gain 20364138
nsv830011 CNV gain 17160897
nsv964075 CNV duplication 23825009

Variation tolerance for UNC5C Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.02; 96.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNC5C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5C Gene

Disorders for UNC5C Gene

Additional Disease Information for UNC5C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UNC5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC5C Gene

Publications for UNC5C Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K … Mehlen P (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 22 58
  2. Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. (PMID: 9782087) Ackerman SL … Knowles BB (Genomics 1998) 2 3 4 22 58
  3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study. (PMID: 20932310) Han MR … Alzheimer's Disease Neuroimaging Initiative (BMC neurology 2010) 3 44 58

Products for UNC5C Gene

Sources for UNC5C Gene

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