Aliases for KLF7 Gene
External Ids for KLF7 Gene
Previous GeneCards Identifiers for KLF7 Gene
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for KLF7 Gene
KLF7 (Kruppel Like Factor 7) is a Protein Coding gene. Diseases associated with KLF7 include Bruxism. Among its related pathways are Adipogenesis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is KLF6.
UniProtKB/Swiss-Prot for KLF7 Gene
Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.