Aliases for RGS20 Gene
External Ids for RGS20 Gene
Previous GeneCards Identifiers for RGS20 Gene
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for RGS20 Gene
RGS20 (Regulator Of G Protein Signaling 20) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS17.
UniProtKB/Swiss-Prot for RGS20 Gene
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).