Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MKNK1 Gene

Aliases for MKNK1 Gene

  • MAP Kinase Interacting Serine/Threonine Kinase 1 2 3 5
  • MAP Kinase Signal-Integrating Kinase 1 3 4
  • MAPK Signal-Integrating Kinase 1 3 4
  • MNK1 3 4
  • MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 3
  • EC 4
  • Mnk1 4

External Ids for MKNK1 Gene

Previous GeneCards Identifiers for MKNK1 Gene

  • GC01M046717
  • GC01M045980
  • GC01M046409
  • GC01M046393
  • GC01M046735
  • GC01M046795
  • GC01M047023
  • GC01M045139

Summaries for MKNK1 Gene

Entrez Gene Summary for MKNK1 Gene

  • This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for MKNK1 Gene

MKNK1 (MAP Kinase Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Among its related pathways are p38 MAPK Signaling Pathway (WikiPathways) and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for MKNK1 Gene

  • May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Tocris Summary for MKNK1 Gene

  • Mitogen-activated protein kinase (MAPK) interacting protein kinases (Mnks) are a family of serine/threonine kinases. Mnks are downstream effectors of MAPK signaling, and have been implicated in oncogenic transformation and progression

Gene Wiki entry for MKNK1 Gene

Additional gene information for MKNK1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKNK1 Gene

Genomics for MKNK1 Gene

GeneHancer (GH) Regulatory Elements for MKNK1 Gene

Promoters and enhancers for MKNK1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J046603 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 674.7 +12.5 12473 2.7 HDGF ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ZNF143 SP3 MKNK1 GC01P046604 EFCAB14 TEX38 EFCAB14-AS1 ATPAF1 KNCN
GH01J046610 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 25.6 +2.5 2529 7 PKNOX1 ATF1 ARNT SIN3A GLIS2 ELK1 ZNF143 ZFP91 FOS ATF7 MOB3C MKNK1 GC01P046604
GH01J046594 Enhancer 0.9 Ensembl ENCODE 38 +21.8 21837 2 ATF1 PKNOX1 MAX ZNF766 POLR2A SCRT2 VEZF1 CBFA2T2 ATF7 RUNX3 MKNK1 MOB3C EFCAB14 TEX38 ATPAF1 EFCAB14-AS1 GC01P046604 KNCN
GH01J046580 Enhancer 0.8 Ensembl ENCODE 26.8 +36.0 36017 0.8 SMARCA5 ESRRA FOXA2 E2F5 ZMYM3 FOSL1 ZNF121 HDAC2 POLR2A ADNP MKNK1 GC01P046604 KNCN
GH01J046583 Enhancer 0.6 ENCODE 27.5 +35.0 35039 0.3 SMARCE1 BCOR MEIS2 PKNOX1 E2F5 NRF1 CEBPB ZMYM3 CEBPG ZNF664 MKNK1 GC01P046604 KNCN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MKNK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MKNK1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • ATF
  • SRF (504 AA)
  • Nkx2-5
  • PPAR-alpha

Genomic Locations for MKNK1 Gene

Genomic Locations for MKNK1 Gene
59,437 bases
Minus strand
59,426 bases
Minus strand

Genomic View for MKNK1 Gene

Genes around MKNK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKNK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKNK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKNK1 Gene

Proteins for MKNK1 Gene

  • Protein details for MKNK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAP kinase-interacting serine/threonine-protein kinase 1
    Protein Accession:
    Secondary Accessions:
    • D3DQ20
    • D3DQ21
    • O00312
    • Q5TC06
    • Q5TC07
    • Q6V0N6

    Protein attributes for MKNK1 Gene

    465 amino acids
    Molecular mass:
    51342 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.

    Three dimensional structures from OCA and Proteopedia for MKNK1 Gene

    Alternative splice isoforms for MKNK1 Gene


neXtProt entry for MKNK1 Gene

Post-translational modifications for MKNK1 Gene

  • Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MKNK1 Gene

Domains & Families for MKNK1 Gene

Gene Families for MKNK1 Gene

Protein Domains for MKNK1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MKNK1: view

Function for MKNK1 Gene

Molecular function for MKNK1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.

Enzyme Numbers (IUBMB) for MKNK1 Gene

Phenotypes From GWAS Catalog for MKNK1 Gene

Gene Ontology (GO) - Molecular Function for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0005515 protein binding IPI 9878069
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with MKNK1: view
genes like me logo Genes that share phenotypes with MKNK1: view

Animal Models for MKNK1 Gene

MGI Knock Outs for MKNK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MKNK1

miRNA for MKNK1 Gene

miRTarBase miRNAs that target MKNK1

Clone Products

  • Addgene plasmids for MKNK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MKNK1 Gene

Localization for MKNK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKNK1 Gene

Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MKNK1 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MKNK1: view

Pathways & Interactions for MKNK1 Gene

genes like me logo Genes that share pathways with MKNK1: view

SIGNOR curated interactions for MKNK1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006468 protein phosphorylation IEA,IDA 9155018
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IDA 17130135
GO:0035556 intracellular signal transduction IDA 9155018
genes like me logo Genes that share ontologies with MKNK1: view

Drugs & Compounds for MKNK1 Gene

(10) Drugs for MKNK1 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
Cercosporamide Pharma Mnk2 and JAK3 inhibitor, Potent Mnk2 inhibitor 0
CGP 57380 Pharma Selective inhibitor of Mnk1 0

(3) Additional Compounds for MKNK1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
ETP 45835 dihydrochloride

(3) Tocris Compounds for MKNK1 Gene

Compound Action Cas Number
Cercosporamide Potent Mnk2 inhibitor 131436-22-1
CGP 57380 Selective inhibitor of Mnk1 522629-08-9
ETP 45835 dihydrochloride Mnk1 and Mnk2 inhibitor
genes like me logo Genes that share compounds with MKNK1: view

Transcripts for MKNK1 Gene

Unigene Clusters for MKNK1 Gene

MAP kinase interacting serine/threonine kinase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for MKNK1

Alternative Splicing Database (ASD) splice patterns (SP) for MKNK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: -
SP10: - - - -
SP11: - - - -
SP12: -

ExUns: 17b ^ 18 ^ 19a · 19b · 19c
SP3: -
SP5: -
SP6: -

Relevant External Links for MKNK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MKNK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MKNK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKNK1 Gene

This gene is overexpressed in Whole Blood (x11.0) and Pancreas (x4.4).

Protein differential expression in normal tissues from HIPED for MKNK1 Gene

This gene is overexpressed in Pancreas (51.1) and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MKNK1 Gene

Protein tissue co-expression partners for MKNK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MKNK1 Gene:


SOURCE GeneReport for Unigene cluster for MKNK1 Gene:


mRNA Expression by UniProt/SwissProt for MKNK1 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for MKNK1 Gene

  • Blood(4.3)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with MKNK1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MKNK1 Gene

Orthologs for MKNK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MKNK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MKNK1 33
  • 99.26 (n)
(Bos Taurus)
Mammalia MKNK1 34 33
  • 91.44 (n)
(Canis familiaris)
Mammalia MKNK1 33
  • 90.61 (n)
-- 34
  • 84 (a)
-- 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Mknk1 33
  • 88.64 (n)
(Mus musculus)
Mammalia Mknk1 16 34 33
  • 88.02 (n)
(Monodelphis domestica)
Mammalia MKNK1 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia MKNK1 34
  • 78 (a)
(Gallus gallus)
Aves MKNK1 34 33
  • 75.96 (n)
(Anolis carolinensis)
Reptilia MKNK1 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mknk1 33
  • 73.96 (n)
Str.15197 33
African clawed frog
(Xenopus laevis)
Amphibia mnk1 33
(Danio rerio)
Actinopterygii mknk1 34 33
  • 72.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Lk6 34 35 33
  • 60.32 (n)
(Caenorhabditis elegans)
Secernentea mnk-1 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 34
  • 23 (a)
RCK2 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11342 34
  • 58 (a)
Species where no ortholog for MKNK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MKNK1 Gene

Gene Tree for MKNK1 (if available)
Gene Tree for MKNK1 (if available)
Evolutionary constrained regions (ECRs) for MKNK1: view image

Paralogs for MKNK1 Gene

Paralogs for MKNK1 Gene

(48) SIMAP similar genes for MKNK1 Gene using alignment to 17 proteins:

  • B4E1V9_HUMAN
  • B5BU64_HUMAN
  • E9PN34_HUMAN
  • E9PQ23_HUMAN
  • E9PQ26_HUMAN
  • H0YE67_HUMAN
genes like me logo Genes that share paralogs with MKNK1: view

Variants for MKNK1 Gene

Sequence variations from dbSNP and Humsavar for MKNK1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000001941 -- 46,591,819(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000097993 -- 46,575,779(-) C/T intron_variant
rs1000178619 -- 46,584,974(-) G/A 5_prime_UTR_variant, intron_variant
rs1000252703 -- 46,578,324(-) G/A intron_variant
rs1000349808 -- 46,603,460(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MKNK1 Gene

Variant ID Type Subtype PubMed ID
esv2761743 CNV gain 21179565
esv3329869 CNV duplication 20981092
nsv1008246 CNV loss 25217958
nsv1009193 CNV gain 25217958
nsv755 CNV insertion 18451855

Variation tolerance for MKNK1 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MKNK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKNK1 Gene

Disorders for MKNK1 Gene

Additional Disease Information for MKNK1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MKNK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MKNK1 Gene

Publications for MKNK1 Gene

  1. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. (PMID: 15234964) Orton KC … Traugh JA (The Journal of biological chemistry 2004) 3 4 22 58
  2. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PMID: 9878069) Pyronnet S … Sonenberg N (The EMBO journal 1999) 3 4 22 58
  3. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. (PMID: 9155018) Fukunaga R … Hunter T (The EMBO journal 1997) 2 3 4 58
  4. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PMID: 20805296) Coulthard LR … McDermott MF (Annals of the rheumatic diseases 2011) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for MKNK1 Gene

Sources for MKNK1 Gene

Loading form....