Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RRP1 Gene

Aliases for RRP1 Gene

  • Ribosomal RNA Processing 1 2 3 5
  • Novel Nuclear Protein 1 3 4
  • Nucleolar Protein Nop52 3 4
  • RRP1-Like Protein 3 4
  • D21S2056E 3 4
  • NNP-1 3 4
  • NOP52 3 4
  • RRP1A 3 4
  • DNA Segment On Chromosome 21 (Unique) 2056 Expressed Sequence 2
  • Ribosomal RNA Processing 1 Homolog (S. Cerevisiae) 2
  • Ribosomal RNA Processing Protein 1 Homolog A 3
  • Nnp1 Homolog, Nucleolar Protein (Drosophila) 2
  • Ribosomal RNA Processing 1 Homolog 3
  • Nnp1 Homolog, Nucleolar Protein 3
  • Protein NNP-1 3
  • NNP1 4

External Ids for RRP1 Gene

Previous GeneCards Identifiers for RRP1 Gene

  • GC21P044035
  • GC21P045209
  • GC21P030577

Summaries for RRP1 Gene

Entrez Gene Summary for RRP1 Gene

  • The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for RRP1 Gene

RRP1 (Ribosomal RNA Processing 1) is a Protein Coding gene. An important paralog of this gene is RRP1B.

UniProtKB/Swiss-Prot for RRP1 Gene

  • Plays a critical role in the generation of 28S rRNA.

Gene Wiki entry for RRP1 Gene

Additional gene information for RRP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP1 Gene

Genomics for RRP1 Gene

GeneHancer (GH) Regulatory Elements for RRP1 Gene

Promoters and enhancers for RRP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J043788 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 659 +0.2 243 2.4 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B IRF4 YY1 RRP1 RRP1B ENSG00000184441 WDR4 PKNOX1 SIK1 PWP2 U2AF1 C21orf2 AATBC
GH21J043774 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 7.7 -13.7 -13655 2.4 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF207 SP3 SP5 MXD4 CSTB GC21M043771 WDR4 ENSG00000184441 U2AF1 RRP1B PKNOX1 PWP2 ENSG00000233754 C21orf2
GH21J043974 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.6 +186.0 185966 1 HDGF ATF1 ARNT SIN3A YBX1 GLI4 TCF12 ZNF280A POLR2B CBX5 RRP1B PWP2 U2AF1 TRAPPC10 AATBC SIK1 UBE2G2 RNU6-859P AGPAT3 RRP1
GH21J043782 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 9.4 -6.4 -6443 1.7 FOXA2 MLX ARID4B NEUROD1 DMAP1 ZNF48 YY1 SLC30A9 FOS NFKBIZ TMEM97P1 CSTB RRP1 AATBC LOC105372825
GH21J043834 Enhancer 0.6 Ensembl ENCODE 17.9 +45.6 45588 1.4 MAX ZBTB33 MYC RRP1 AATBC AGPAT3 TMEM97P1 RNU6-859P CSTB PDXK GC21M043858 GC21P043803
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RRP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RRP1 gene promoter:
  • ATF
  • USF2
  • USF1
  • USF-1:USF-2
  • USF-1
  • Max
  • c-Myc
  • AP-4
  • SRF
  • SRF (504 AA)

Genomic Locations for RRP1 Gene

Genomic Locations for RRP1 Gene
15,781 bases
Plus strand
15,781 bases
Plus strand

Genomic View for RRP1 Gene

Genes around RRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP1 Gene

Proteins for RRP1 Gene

  • Protein details for RRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal RNA processing protein 1 homolog A
    Protein Accession:
    Secondary Accessions:
    • Q9NST5

    Protein attributes for RRP1 Gene

    461 amino acids
    Molecular mass:
    52839 Da
    Quaternary structure:
    • Interacts with C1QBP (PubMed:21536856). Interacts with RRP1B (PubMed:20926688).

neXtProt entry for RRP1 Gene

Post-translational modifications for RRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRP1 Gene

No data available for DME Specific Peptides for RRP1 Gene

Domains & Families for RRP1 Gene

Gene Families for RRP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRP1 Gene


Suggested Antigen Peptide Sequences for RRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRP1 family.
  • Belongs to the RRP1 family.
genes like me logo Genes that share domains with RRP1: view

Function for RRP1 Gene

Molecular function for RRP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in the generation of 28S rRNA.

Gene Ontology (GO) - Molecular Function for RRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with RRP1: view
genes like me logo Genes that share phenotypes with RRP1: view

Animal Model Products

miRNA for RRP1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP1 Gene

Localization for RRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP1 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9192856
GO:0005730 nucleolus IDA,IEA --
GO:0030687 preribosome, large subunit precursor IBA --
GO:0030688 preribosome, small subunit precursor IEA --
genes like me logo Genes that share ontologies with RRP1: view

Pathways & Interactions for RRP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA,IEA --
genes like me logo Genes that share ontologies with RRP1: view

No data available for Pathways by source and SIGNOR curated interactions for RRP1 Gene

Drugs & Compounds for RRP1 Gene

No Compound Related Data Available

Transcripts for RRP1 Gene

Unigene Clusters for RRP1 Gene

Ribosomal RNA processing 1 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -

Relevant External Links for RRP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.3), Lung (7.9), and Pancreas (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RRP1 Gene

Protein tissue co-expression partners for RRP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRP1 Gene:


SOURCE GeneReport for Unigene cluster for RRP1 Gene:


mRNA Expression by UniProt/SwissProt for RRP1 Gene:

Tissue specificity: Ubiquitously expressed in fetal and adult tissues.

Evidence on tissue expression from TISSUES for RRP1 Gene

  • Lung(4.3)
  • Intestine(4.2)
  • Kidney(4.2)
  • Liver(4.2)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with RRP1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRP1 Gene

Orthologs for RRP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRP1 34 33
  • 99.06 (n)
(Canis familiaris)
Mammalia RRP1 34 33
  • 76.58 (n)
(Rattus norvegicus)
Mammalia Rrp1 33
  • 75.98 (n)
(Bos Taurus)
Mammalia RRP1 34 33
  • 75.69 (n)
(Mus musculus)
Mammalia Rrp1 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia RRP1 34
  • 55 (a)
(Monodelphis domestica)
Mammalia RRP1 34
  • 35 (a)
(Gallus gallus)
Aves RRP1B 34
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8175 33
(Danio rerio)
Actinopterygii rrp1 34
  • 26 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4334 33
fruit fly
(Drosophila melanogaster)
Insecta Nnp-1 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea C47E12.7 34 33
  • 43.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP1 34
  • 25 (a)
Species where no ortholog for RRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRP1 Gene

Gene Tree for RRP1 (if available)
Gene Tree for RRP1 (if available)
Evolutionary constrained regions (ECRs) for RRP1: view image

Paralogs for RRP1 Gene

Paralogs for RRP1 Gene

(1) SIMAP similar genes for RRP1 Gene using alignment to 3 proteins:

  • D6RE82_HUMAN
genes like me logo Genes that share paralogs with RRP1: view

Variants for RRP1 Gene

Sequence variations from dbSNP and Humsavar for RRP1 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs763767114 uncertain-significance, Ductal breast carcinoma 43,793,384(+) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000510223 -- 43,794,239(+) C/G/T intron_variant
rs1001065902 -- 43,798,697(+) A/G intron_variant
rs1001150679 -- 43,792,412(+) T/A intron_variant
rs1001182464 -- 43,804,155(+) G/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RRP1 Gene

Variant ID Type Subtype PubMed ID
esv33817 CNV loss 17666407
nsv470904 CNV loss 18288195
nsv509799 CNV insertion 20534489
nsv520305 CNV loss 19592680
nsv522204 CNV loss 19592680
nsv587718 CNV loss 21841781
nsv587719 CNV loss 21841781
nsv834107 CNV loss 17160897
nsv834108 CNV loss 17160897
nsv953642 CNV deletion 24416366

Variation tolerance for RRP1 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.77; 89.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP1 Gene

Disorders for RRP1 Gene

Additional Disease Information for RRP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP1 Gene

Publications for RRP1 Gene

  1. The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis. (PMID: 10341208) Savino TM … Hernandez-Verdun D (Journal of cell science 1999) 2 3 4 22 58
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 2 3 4 58
  3. The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3. (PMID: 9192856) Jansen E … Van de Ven WJ (Genomics 1997) 3 4 22 58
  4. Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles. (PMID: 21536856) Yoshikawa H … Takahashi N (Molecular & cellular proteomics : MCP 2011) 3 4 58
  5. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3 44 58

Products for RRP1 Gene

Sources for RRP1 Gene

Loading form....