Aliases for DIXDC1 Gene
External Ids for DIXDC1 Gene
Previous GeneCards Identifiers for DIXDC1 Gene
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
GeneCards Summary for DIXDC1 Gene
DIXDC1 (DIX Domain Containing 1) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include actin binding and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is DVL3.
UniProtKB/Swiss-Prot for DIXDC1 Gene
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.