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Aliases for DGKE Gene

Aliases for DGKE Gene

  • Diacylglycerol Kinase Epsilon 2 3 3 5
  • Diacylglycerol Kinase, Epsilon 64kDa 2 3
  • Diglyceride Kinase Epsilon 3 4
  • DAG Kinase Epsilon 3 4
  • DGK-Epsilon 3 4
  • DAGK5 3 4
  • Diacylglycerol Kinase, Epsilon (64kD) 2
  • EC 4
  • AHUS7 3
  • DAGK6 3
  • NPHS7 3
  • DGK 3

External Ids for DGKE Gene

Previous GeneCards Identifiers for DGKE Gene

  • GC17P054648
  • GC17P057392
  • GC17P055253
  • GC17P055386
  • GC17P052266
  • GC17P054911
  • GC17P050271

Summaries for DGKE Gene

Entrez Gene Summary for DGKE Gene

  • Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKE Gene

DGKE (Diacylglycerol Kinase Epsilon) is a Protein Coding gene. Diseases associated with DGKE include Nephrotic Syndrome, Type 7 and Hemolytic Uremic Syndrome, Atypical 1. Among its related pathways are Effects of PIP2 hydrolysis and Glycerolipid metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKK.

UniProtKB/Swiss-Prot for DGKE Gene

  • Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Tocris Summary for DGKE Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Additional gene information for DGKE Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKE Gene

Genomics for DGKE Gene

GeneHancer (GH) Regulatory Elements for DGKE Gene

Promoters and enhancers for DGKE Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J056832 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 668.9 -0.1 -88 3.3 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 DGKE C17orf67 PIR41486 GC17M056820 GC17M056657
GH17J056911 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.6 +80.9 80893 6.8 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A SSRP1 ZNF610 TRIM25 ENSG00000274213 DGKE ENSG00000262298 SCPEP1
GH17J057460 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +629.4 629438 6.7 HDGF PKNOX1 ZNF493 ZFP64 ZBTB7B IRF4 ZNF121 ZNF213 ZNF207 ATF7 SRSF1 MKS1 ENSG00000262298 COIL DGKE MSI2 VEZF1 DYNLL2 ENSG00000279281 LOC101927557
GH17J057084 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.9 +252.9 252856 5.5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 ENSG00000263004 AKAP1 SRSF1 COIL ENSG00000262298 DGKE VEZF1 SCPEP1 ENSG00000263089
GH17J056592 Promoter/Enhancer 1.5 Ensembl ENCODE 13.4 -238.3 -238272 6.5 SIN3A ZNF2 ZNF213 ZNF207 ZNF143 KLF13 SP3 REST ZFP41 SREBF1 COIL LOC100419768 LOC101927557 ENSG00000262298 DGKE MSI2 NOG GC17M056599
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGKE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DGKE gene promoter:
  • RFX1
  • HEN1
  • AREB6
  • NRF-2
  • MEF-2A
  • aMEF-2
  • MIF-1
  • FOXO3
  • FOXO3a
  • FOXO3b

Genomic Locations for DGKE Gene

Genomic Locations for DGKE Gene
35,469 bases
Plus strand
34,577 bases
Plus strand

Genomic View for DGKE Gene

Genes around DGKE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKE Gene

Proteins for DGKE Gene

  • Protein details for DGKE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Diacylglycerol kinase epsilon
    Protein Accession:
    Secondary Accessions:
    • Q8TBM4
    • Q9UKQ3

    Protein attributes for DGKE Gene

    567 amino acids
    Molecular mass:
    63927 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DGKE Gene


neXtProt entry for DGKE Gene

Post-translational modifications for DGKE Gene

  • Ubiquitination at Lys357
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DGKE
  • Boster Bio Antibodies for DGKE
  • Santa Cruz Biotechnology (SCBT) Antibodies for DGKE

No data available for DME Specific Peptides for DGKE Gene

Domains & Families for DGKE Gene

Gene Families for DGKE Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKE: view

Function for DGKE Gene

Molecular function for DGKE Gene

UniProtKB/Swiss-Prot Function:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
GENATLAS Biochemistry:
diacylglycerol kinase epsilon,expressed predominantly in the testis and the retina,converting diacylglycerol to phosphatidic acid,involved in the phosphorylation of arachidonate containing diacylglycerol,

Enzyme Numbers (IUBMB) for DGKE Gene

Gene Ontology (GO) - Molecular Function for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA,TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA,IDA 18004883
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DGKE: view
genes like me logo Genes that share phenotypes with DGKE: view

Human Phenotype Ontology for DGKE Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DGKE Gene

MGI Knock Outs for DGKE:

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKE

miRNA for DGKE Gene

Clone Products

  • Addgene plasmids for DGKE

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for DGKE Gene

Localization for DGKE Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKE Gene

Membrane; Multi-pass membrane protein. Membrane. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKE gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA,IDA 23542698
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA,IEA 23542698
genes like me logo Genes that share ontologies with DGKE: view

Pathways & Interactions for DGKE Gene

genes like me logo Genes that share pathways with DGKE: view

Gene Ontology (GO) - Biological Process for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0008152 metabolic process IEA --
GO:0008654 phospholipid biosynthetic process TAS 8626589
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DGKE: view

No data available for SIGNOR curated interactions for DGKE Gene

Drugs & Compounds for DGKE Gene

(6) Drugs for DGKE Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(25) Additional Compounds for DGKE Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group C
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z,14Z)-icosa-11,14-dienoic acid
  • DAG(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2)
  • DAG(15:0/0:0/20:2n6)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(2) Tocris Compounds for DGKE Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKE: view

Transcripts for DGKE Gene

Unigene Clusters for DGKE Gene

Diacylglycerol kinase, epsilon 64kDa:
Representative Sequences:

Clone Products

  • Addgene plasmids for DGKE

Alternative Splicing Database (ASD) splice patterns (SP) for DGKE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -

Relevant External Links for DGKE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGKE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGKE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DGKE Gene

This gene is overexpressed in Retina (45.5) and Testis (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DGKE Gene

NURSA nuclear receptor signaling pathways regulating expression of DGKE Gene:


SOURCE GeneReport for Unigene cluster for DGKE Gene:


mRNA Expression by UniProt/SwissProt for DGKE Gene:

Tissue specificity: Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level).

Evidence on tissue expression from TISSUES for DGKE Gene

  • Heart(4.1)
  • Nervous system(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKE Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • immune
  • integumentary
  • respiratory
  • urinary
  • lung
  • kidney
  • urinary bladder
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with DGKE: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DGKE Gene

Orthologs for DGKE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DGKE 34 33
  • 99.35 (n)
(Canis familiaris)
Mammalia DGKE 34 33
  • 91.43 (n)
(Bos Taurus)
Mammalia DGKE 34 33
  • 90.96 (n)
(Mus musculus)
Mammalia Dgke 16 34 33
  • 87.23 (n)
(Monodelphis domestica)
Mammalia DGKE 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia DGKE 34
  • 80 (a)
(Gallus gallus)
Aves DGKE 34 33
  • 77.11 (n)
(Anolis carolinensis)
Reptilia DGKE 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dgke 33
  • 72.7 (n)
(Danio rerio)
Actinopterygii dgke 34 33
  • 68.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006768 33
  • 49.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dgkepsilon 34 33
  • 48.26 (n)
Dgk&egr; 35
  • 37 (a)
(Caenorhabditis elegans)
Secernentea dgk-2 34 35 33
  • 48.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DGK1 33
  • 47.29 (n)
(Oryza sativa)
Liliopsida Os12g0576900 33
  • 47.77 (n)
Species where no ortholog for DGKE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKE Gene

Gene Tree for DGKE (if available)
Gene Tree for DGKE (if available)
Evolutionary constrained regions (ECRs) for DGKE: view image

Paralogs for DGKE Gene

Paralogs for DGKE Gene

(2) SIMAP similar genes for DGKE Gene using alignment to 5 proteins:

  • A1L4Q0_HUMAN
  • I3L112_HUMAN
  • I3L2V2_HUMAN
genes like me logo Genes that share paralogs with DGKE: view

Variants for DGKE Gene

Sequence variations from dbSNP and Humsavar for DGKE Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1060499708 pathogenic, Nephrotic syndrome, type 7 56,861,882(+) G/A 3_prime_UTR_variant, coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, stop_gained
rs1060499709 likely-pathogenic, Nephrotic syndrome, type 7 56,856,582(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1064797074 likely-pathogenic, Nephrotic syndrome, type 7 56,845,792(+) TTGTT/T coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs138924661 risk-factor, likely-pathogenic, Hemolytic uremic syndrome, atypical, susceptibility to, 7, Atypical hemolytic uremic syndrome 56,848,773(+) G/A coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs147972030 pathogenic, Nephrotic syndrome, type 7 56,844,158(+) AAAAAAA/AAAAAA/AAAAAAAA coding_sequence_variant, frameshift, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DGKE Gene

Variant ID Type Subtype PubMed ID
esv2658087 CNV deletion 23128226
esv32884 CNV loss 17666407
nsv1142226 CNV tandem duplication 24896259
nsv833495 CNV loss 17160897

Variation tolerance for DGKE Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKE Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKE Gene

Disorders for DGKE Gene

MalaCards: The human disease database

(5) MalaCards diseases for DGKE Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nephrotic syndrome, type 7
  • nphs7
hemolytic uremic syndrome, atypical 1
  • hemolytic uremic syndrome, atypical, susceptibility to, 1
dense deposit disease
  • ddd
hemolytic-uremic syndrome
  • haemolytic-uraemic syndrome
methylmalonic aciduria and homocystinuria, cblc type
  • mahcc
- elite association - COSMIC cancer census association via MalaCards
Search DGKE in MalaCards View complete list of genes associated with diseases


  • Nephrotic syndrome 7 (NPHS7) [MIM:615008]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. NPHS7 is an autosomal recessive form characterized by onset of proteinuria usually in the first decade of life. The disorder is progressive, and some patients develop end-stage renal disease within several years. Renal biopsy typically shows membranoproliferative glomerulonephritis. {ECO:0000269 PubMed:23274426}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hemolytic uremic syndrome atypical 7 (AHUS7) [MIM:615008]: An atypical form of hemolytic uremic syndrome characterized by acute onset in the first year of life of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. After the acute episode, most patients develop chronic renal insufficiency. Unlike other genetic forms of aHUS, AHUS7 is not related to abnormal activation of the complement system. {ECO:0000269 PubMed:23542698}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for DGKE

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DGKE: view

No data available for Genatlas for DGKE Gene

Publications for DGKE Gene

  1. Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates. (PMID: 8626589) Tang W … Prescott SM (The Journal of biological chemistry 1996) 2 3 4 22 58
  2. Characterization of the human diacylglycerol kinase epsilon gene and its assessment as a candidate for inherited retinitis pigmentosa. (PMID: 10571048) Tang W … Prescott SM (Gene 1999) 3 4 22 58
  3. DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. (PMID: 23274426) Ozaltin F … Attanasio M (Journal of the American Society of Nephrology : JASN 2013) 3 4 58
  4. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. (PMID: 23542698) Lemaire M … Lifton RP (Nature genetics 2013) 3 4 58
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58

Products for DGKE Gene