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Aliases for TNS4 Gene

Aliases for TNS4 Gene

  • Tensin 4 2 3 5
  • C-Terminal Tensin-Like Protein 3 4
  • C Terminal Tensin Like 2 3
  • CTEN 3 4
  • Tensin-4 3
  • PP14434 3

External Ids for TNS4 Gene

Previous GeneCards Identifiers for TNS4 Gene

  • GC17M035886
  • GC17M038632
  • GC17M034425

Summaries for TNS4 Gene

GeneCards Summary for TNS4 Gene

TNS4 (Tensin 4) is a Protein Coding gene. Among its related pathways are MET promotes cell motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for TNS4 Gene

  • May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.

Gene Wiki entry for TNS4 Gene

Additional gene information for TNS4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS4 Gene

Genomics for TNS4 Gene

GeneHancer (GH) Regulatory Elements for TNS4 Gene

Promoters and enhancers for TNS4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J040478 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 657.7 +11.2 11223 24 PKNOX1 CLOCK SMAD1 FOXA2 ZFP64 SIN3A FEZF1 IRF4 YY1 ZNF143 TNS4 SNORD124 SMARCE1 MED24 IGFBP4 KRT10 RPL23AP75 TOP2A RAPGEFL1 CDC6
GH17J040455 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +41.1 41067 9.4 ARNT SIN3A ZNF48 YY1 POLR2B ARID2 ZNF207 RXRA REST ZNF623 CDC6 LOC105371776 KRTAP9-2 RPL23AP75 TNS4 GJD3 TOP2A KRT23 ENSG00000266208 IGFBP4
GH17J040509 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.4 -10.0 -9956 4.3 ARID4B KLF17 SIN3A DMAP1 THRB RARA ZSCAN5C RCOR1 FOS SMARCC1 IGFBP4 RPL23AP75 TOP2A CDC6 RARA PNMT TNS4 LOC105371773
GH17J040515 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.4 -18.4 -18389 9.6 FOXA2 ARNT DMAP1 ZNF766 FOS SP5 REST SMARCB1 ZNF592 KAT8 TOP2A CDC6 CCR7 IGFBP4 RPL23AP75 GJD3 RARA SMARCE1 PPIAP54 TNS4
GH17J040471 Enhancer 0.5 ENCODE dbSUPER 11.8 +31.4 31377 0.1 ZNF664 IGFBP4 RPL23AP75 TNS4 TOP2A CDC6 GC17P040473
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNS4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNS4 gene promoter:
  • AREB6
  • GR-beta
  • GR-alpha
  • GR
  • IRF-7A
  • Bach1
  • Roaz
  • Meis-1a
  • Meis-1b
  • Meis-1

Genomic Locations for TNS4 Gene

Genomic Locations for TNS4 Gene
chr17:40,475,828-40,501,681
(GRCh38/hg38)
Size:
25,854 bases
Orientation:
Minus strand
chr17:38,632,080-38,657,854
(GRCh37/hg19)
Size:
25,775 bases
Orientation:
Minus strand

Genomic View for TNS4 Gene

Genes around TNS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS4 Gene

Proteins for TNS4 Gene

  • Protein details for TNS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZW8-TENS4_HUMAN
    Recommended name:
    Tensin-4
    Protein Accession:
    Q8IZW8
    Secondary Accessions:
    • A6NMJ7
    • Q71RB7
    • Q8WV64
    • Q96JV4

    Protein attributes for TNS4 Gene

    Size:
    715 amino acids
    Molecular mass:
    76764 Da
    Quaternary structure:
    • Binds to actin filaments and interacts with phosphotyrosine-containing proteins.
    SequenceCaution:
    • Sequence=AAQ15257.1; Type=Frameshift; Positions=85, 296, 472, 602; Evidence={ECO:0000305};

neXtProt entry for TNS4 Gene

Post-translational modifications for TNS4 Gene

Other Protein References for TNS4 Gene

Antibody Products

  • Abcam antibodies for TNS4
  • Boster Bio Antibodies for TNS4
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNS4

No data available for DME Specific Peptides for TNS4 Gene

Domains & Families for TNS4 Gene

Gene Families for TNS4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TNS4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNS4: view

No data available for UniProtKB/Swiss-Prot for TNS4 Gene

Function for TNS4 Gene

Molecular function for TNS4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.

Phenotypes From GWAS Catalog for TNS4 Gene

Gene Ontology (GO) - Molecular Function for TNS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 17190795
genes like me logo Genes that share ontologies with TNS4: view
genes like me logo Genes that share phenotypes with TNS4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNS4 Gene

Localization for TNS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS4 Gene

Cell junction, focal adhesion. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNS4 gene
Compartment Confidence
cytosol 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for TNS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IEA,IDA 17190795
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with TNS4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNS4 Gene

Pathways & Interactions for TNS4 Gene

genes like me logo Genes that share pathways with TNS4: view

Pathways by source for TNS4 Gene

Gene Ontology (GO) - Biological Process for TNS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008104 protein localization IDA 17190795
genes like me logo Genes that share ontologies with TNS4: view

No data available for SIGNOR curated interactions for TNS4 Gene

Drugs & Compounds for TNS4 Gene

No Compound Related Data Available

Transcripts for TNS4 Gene

Unigene Clusters for TNS4 Gene

Tensin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS4

Alternative Splicing Database (ASD) splice patterns (SP) for TNS4 Gene

No ASD Table

Relevant External Links for TNS4 Gene

GeneLoc Exon Structure for
TNS4
ECgene alternative splicing isoforms for
TNS4

Expression for TNS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNS4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.2), Skin - Sun Exposed (Lower leg) (x13.9), Vagina (x5.2), and Minor Salivary Gland (x5.0).

Protein differential expression in normal tissues from HIPED for TNS4 Gene

This gene is overexpressed in Plasma (49.5) and Placenta (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNS4 Gene



Protein tissue co-expression partners for TNS4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNS4 Gene:

TNS4

SOURCE GeneReport for Unigene cluster for TNS4 Gene:

Hs.438292

mRNA Expression by UniProt/SwissProt for TNS4 Gene:

Q8IZW8-TENS4_HUMAN
Tissue specificity: Prostate and placenta. Down regulated in prostate cancer.

Evidence on tissue expression from TISSUES for TNS4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TNS4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNS4 Gene

Orthologs for TNS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNS4 34 33
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNS4 34 33
  • 86.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TNS4 34 33
  • 85.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tns4 16 34 33
  • 81.36 (n)
rat
(Rattus norvegicus)
Mammalia Tns4 33
  • 80.45 (n)
oppossum
(Monodelphis domestica)
Mammalia TNS4 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNS4 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNS4 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNS4 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tns4 33
  • 53.22 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26026 33
fruit fly
(Drosophila melanogaster)
Insecta by 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-163 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
OneToMany
Species where no ortholog for TNS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TNS4 Gene

ENSEMBL:
Gene Tree for TNS4 (if available)
TreeFam:
Gene Tree for TNS4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNS4: view image

Paralogs for TNS4 Gene

Paralogs for TNS4 Gene

(5) SIMAP similar genes for TNS4 Gene using alignment to 5 proteins:

  • TENS4_HUMAN
  • J3QLA4_HUMAN
  • L0R5F6_HUMAN
  • L8E9G9_HUMAN
  • Q6PJP3_HUMAN
genes like me logo Genes that share paralogs with TNS4: view

Variants for TNS4 Gene

Sequence variations from dbSNP and Humsavar for TNS4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs148022611 A colorectal cancer sample 40,478,635(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000088593 -- 40,484,742(-) C/T intron_variant
rs1000120401 -- 40,491,046(-) A/C intron_variant
rs1000361422 -- 40,479,383(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000708779 -- 40,475,349(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TNS4 Gene

Variant ID Type Subtype PubMed ID
nsv1058185 CNV loss 25217958
nsv1146669 OTHER inversion 26484159
nsv833445 CNV loss 17160897

Variation tolerance for TNS4 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.18; 90.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNS4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS4 Gene

Disorders for TNS4 Gene

Additional Disease Information for TNS4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNS4 Gene

Publications for TNS4 Gene

  1. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. (PMID: 12154022) Lo SH … Lo TB (Cancer research 2002) 2 3 4 22 58
  2. Cleavage of cten by caspase-3 during apoptosis. (PMID: 15806167) Lo SS … Lo SH (Oncogene 2005) 3 4 22 58
  3. Cten mRNA expression was correlated with tumor progression in lung cancers. (PMID: 12711115) Sasaki H … Fujii Y (Lung cancer (Amsterdam, Netherlands) 2003) 2 3 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancer. (PMID: 19725034) Li Y … Namiki M (The Prostate 2010) 3 22 58

Products for TNS4 Gene

Sources for TNS4 Gene

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