Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC35B4 Gene

Aliases for SLC35B4 Gene

  • Solute Carrier Family 35 Member B4 2 3 4 5
  • Solute Carrier Family 35 (UDP-Xylose/UDP-N-Acetylglucosamine Transporter), Member B4 2 3
  • YEA4 Homolog 3 4
  • YEA4 3 4
  • UDP-Xylose And UDP-N-Acetylglucosamine Transporter 3
  • UDP-Xylose/N-Acetylglucosamine Transporter 3
  • Solute Carrier Family 35, Member B4 2
  • YEA 3

External Ids for SLC35B4 Gene

Previous GeneCards Identifiers for SLC35B4 Gene

  • GC07M133377
  • GC07M133394
  • GC07M133435
  • GC07M133624
  • GC07M133974
  • GC07M128275

Summaries for SLC35B4 Gene

Entrez Gene Summary for SLC35B4 Gene

  • Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC35B4 Gene

SLC35B4 (Solute Carrier Family 35 Member B4) is a Protein Coding gene. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include UDP-N-acetylglucosamine transmembrane transporter activity and UDP-xylose transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC35B4 Gene

  • Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.

Gene Wiki entry for SLC35B4 Gene

Additional gene information for SLC35B4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B4 Gene

Genomics for SLC35B4 Gene

GeneHancer (GH) Regulatory Elements for SLC35B4 Gene

Promoters and enhancers for SLC35B4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I134315 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 575.8 +3.6 3561 2.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 SLC35B4 PIR38208
GH07I134292 Enhancer 0.9 ENCODE 31.2 +27.2 27167 0.9 FOXA2 ARID4B DMAP1 IRF4 YY1 ATF7 RUNX3 RXRA MIER2 KAT8 PIR38208 SLC35B4 ENSG00000231098
GH07I133492 Enhancer 1.2 ENCODE dbSUPER 18.6 +828.0 827982 0.1 ATF1 FEZF1 ZNF2 ZNF121 GLIS2 ZNF213 KLF7 FOS ATF7 KLF13 SLC35B4 LRGUK RPS15AP23 GC07P133674 EXOC4
GH07I134298 Enhancer 0.5 ENCODE 31.6 +20.9 20948 0.8 ZNF316 MAFG NFE2 EMSY SLC35B4 PIR38208
GH07I134885 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.3 -566.2 -566190 2.9 FOXA2 FEZF1 ZNF48 FOS SP3 REST TSHZ1 MAFF GLIS1 MYNN AGBL3 CALD1 SLC35B4 C7orf49 PIR46779 GC07M134784
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35B4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35B4 gene promoter:

Genomic Locations for SLC35B4 Gene

Genomic Locations for SLC35B4 Gene
30,983 bases
Minus strand

Genomic View for SLC35B4 Gene

Genes around SLC35B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B4 Gene

Proteins for SLC35B4 Gene

  • Protein details for SLC35B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-xylose and UDP-N-acetylglucosamine transporter
    Protein Accession:
    Secondary Accessions:
    • A4D1P3
    • A6NNS4
    • Q53GQ7
    • Q8TCU7
    • Q96K33

    Protein attributes for SLC35B4 Gene

    331 amino acids
    Molecular mass:
    37424 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55325.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35B4 Gene


neXtProt entry for SLC35B4 Gene

Post-translational modifications for SLC35B4 Gene

No Post-translational modifications

Other Protein References for SLC35B4 Gene

No data available for DME Specific Peptides for SLC35B4 Gene

Domains & Families for SLC35B4 Gene

Gene Families for SLC35B4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SLC35B4 Gene


Suggested Antigen Peptide Sequences for SLC35B4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B4: view

Function for SLC35B4 Gene

Molecular function for SLC35B4 Gene

UniProtKB/Swiss-Prot Function:
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.

Phenotypes From GWAS Catalog for SLC35B4 Gene

Gene Ontology (GO) - Molecular Function for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005457 GDP-fucose transmembrane transporter activity IBA --
GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity TAS --
GO:0005464 UDP-xylose transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SLC35B4: view
genes like me logo Genes that share phenotypes with SLC35B4: view

Animal Models for SLC35B4 Gene

MGI Knock Outs for SLC35B4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC35B4 Gene

Localization for SLC35B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B4 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35B4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IDA 21918738
GO:0005794 Golgi apparatus IEA,IDA 15911612
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35B4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC35B4 Gene

Pathways & Interactions for SLC35B4 Gene

genes like me logo Genes that share pathways with SLC35B4: view

Interacting Proteins for SLC35B4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000367770 Q969S0-S35B4_HUMAN for SLC35B4 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006111 regulation of gluconeogenesis IEA --
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015783 GDP-fucose transmembrane transport IBA --
GO:0015790 UDP-xylose transmembrane transport IDA 15911612
genes like me logo Genes that share ontologies with SLC35B4: view

No data available for SIGNOR curated interactions for SLC35B4 Gene

Drugs & Compounds for SLC35B4 Gene

No Compound Related Data Available

Transcripts for SLC35B4 Gene

Unigene Clusters for SLC35B4 Gene

Solute carrier family 35, member B4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B4 Gene

No ASD Table

Relevant External Links for SLC35B4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35B4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35B4 Gene

This gene is overexpressed in Fetal Brain (21.3), Retina (21.1), Testis (14.0), and Ovary (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC35B4 Gene

Protein tissue co-expression partners for SLC35B4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35B4 Gene:


SOURCE GeneReport for Unigene cluster for SLC35B4 Gene:


Evidence on tissue expression from TISSUES for SLC35B4 Gene

  • Liver(4.2)
  • Skin(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC35B4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35B4 Gene

Orthologs for SLC35B4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35B4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35B4 33 34
  • 99.5 (n)
(Bos Taurus)
Mammalia SLC35B4 33 34
  • 92.15 (n)
(Canis familiaris)
Mammalia SLC35B4 33 34
  • 90.61 (n)
(Rattus norvegicus)
Mammalia Slc35b4 33
  • 89.22 (n)
(Monodelphis domestica)
Mammalia SLC35B4 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SLC35B4 34
  • 89 (a)
(Mus musculus)
Mammalia Slc35b4 33 16 34
  • 88.92 (n)
(Gallus gallus)
Aves SLC35B4 33 34
  • 76.54 (n)
(Anolis carolinensis)
Reptilia SLC35B4 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35b4 33
  • 73.01 (n)
(Danio rerio)
Actinopterygii slc35b4 33 34
  • 68.29 (n)
Dr.2187 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011493 33
  • 60.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Efr 33 34
  • 57.62 (n)
CG14511 34
  • 50 (a)
(Caenorhabditis elegans)
Secernentea nstp-2 33 34
  • 51.12 (n)
nstp-1 34
  • 36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03157g 33
  • 45.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YEA4 33 34 36
  • 43.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
-- 34
  • 47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02980 33
  • 46.64 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1734.09 33
  • 46.32 (n)
Species where no ortholog for SLC35B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B4 Gene

Gene Tree for SLC35B4 (if available)
Gene Tree for SLC35B4 (if available)

Paralogs for SLC35B4 Gene

No data available for Paralogs for SLC35B4 Gene

Variants for SLC35B4 Gene

Sequence variations from dbSNP and Humsavar for SLC35B4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000055467 -- 134,314,811(-) G/C intron_variant
rs1000061829 -- 134,308,754(-) C/T intron_variant
rs1000411109 -- 134,318,157(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000559329 -- 134,319,401(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000571595 -- 134,300,961(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35B4 Gene

Variant ID Type Subtype PubMed ID
nsv831145 CNV gain 17160897
nsv608444 CNV gain 21841781
nsv1020759 CNV gain 25217958
esv3615093 CNV gain 21293372
esv3615084 CNV gain 21293372

Variation tolerance for SLC35B4 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B4 Gene

Disorders for SLC35B4 Gene

Additional Disease Information for SLC35B4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC35B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35B4 Gene

Publications for SLC35B4 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine. (PMID: 15911612) Ashikov A … Bakker H (The Journal of biological chemistry 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58

Products for SLC35B4 Gene

Sources for SLC35B4 Gene

Loading form....