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Aliases for TBRG1 Gene

Aliases for TBRG1 Gene

  • Transforming Growth Factor Beta Regulator 1 2 3 3 5
  • Nuclear Interactor Of ARF And MDM2 2 3
  • NIAM 3 4
  • Nuclear Interactor Of ARF And Mdm2 4
  • TB-5 3

External Ids for TBRG1 Gene

Previous GeneCards Identifiers for TBRG1 Gene

  • GC11P126493
  • GC11P126006
  • GC11P124526
  • GC11P124030
  • GC11P123997
  • GC11P124492
  • GC11P120435

Summaries for TBRG1 Gene

GeneCards Summary for TBRG1 Gene

TBRG1 (Transforming Growth Factor Beta Regulator 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Akt Signaling.

UniProtKB/Swiss-Prot for TBRG1 Gene

  • Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.

Gene Wiki entry for TBRG1 Gene

Additional gene information for TBRG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBRG1 Gene

Genomics for TBRG1 Gene

GeneHancer (GH) Regulatory Elements for TBRG1 Gene

Promoters and enhancers for TBRG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124622 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.6 579 2.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B E2F8 TBRG1 RNA5SP352
GH11J125068 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.1 +449.8 449793 8.2 HDGF PKNOX1 FOXA2 ARNT ARID4B IRF4 SP5 ZNF592 KAT8 MEF2D SLC37A2 CCDC15 TMEM218 KRT18P59 ENSG00000255475 ROBO4 HEPACAM LOC105369549 TBRG1 PIR45309
GH11J124275 Enhancer 1.2 FANTOM5 ENCODE 1.9 -346.2 -346198 1.3 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 ATF7 CAVIN1 NCOA1 ZNF592 VWA5A OR8D1 OR8G5 OR8G2P TBRG1 OR8B12 SLC5A4P1
GH11J124177 Enhancer 0.3 FANTOM5 3.3 -445.0 -445035 0.2 VWA5A TBRG1 OR8B12 OR10D3 OR10D1P
GH11J124191 Enhancer 0.4 FANTOM5 1.3 -430.5 -430510 0.3 FOSL1 MAFG VWA5A OR8A1 OR6X1 OR10G7 OR8G2P OR8B12 OR4D5 OR10G4 OR8G1 OR6M1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBRG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TBRG1 gene promoter:
  • E2F-1
  • Evi-1
  • E2F
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • AREB6
  • ISGF-3
  • p53

Genomic Locations for TBRG1 Gene

Genomic Locations for TBRG1 Gene
chr11:124,622,599-124,635,926
(GRCh38/hg38)
Size:
13,328 bases
Orientation:
Plus strand
chr11:124,492,732-124,505,822
(GRCh37/hg19)
Size:
13,091 bases
Orientation:
Plus strand

Genomic View for TBRG1 Gene

Genes around TBRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBRG1 Gene

Proteins for TBRG1 Gene

  • Protein details for TBRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3YBR2-TBRG1_HUMAN
    Recommended name:
    Transforming growth factor beta regulator 1
    Protein Accession:
    Q3YBR2
    Secondary Accessions:
    • Q53GJ5
    • Q66ZJ6
    • Q69YS7
    • Q8TCS4
    • Q8TEI4
    • Q96SV0

    Protein attributes for TBRG1 Gene

    Size:
    411 amino acids
    Molecular mass:
    44946 Da
    Quaternary structure:
    • Interacts with CDKN2A and MDM2.
    SequenceCaution:
    • Sequence=BAB84966.1; Type=Frameshift; Positions=229; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TBRG1 Gene

    Alternative splice isoforms for TBRG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBRG1 Gene

Post-translational modifications for TBRG1 Gene

  • Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBRG1 Gene

No data available for DME Specific Peptides for TBRG1 Gene

Domains & Families for TBRG1 Gene

Gene Families for TBRG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TBRG1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q3YBR2

UniProtKB/Swiss-Prot:

TBRG1_HUMAN :
  • Belongs to the TBRG1 family.
Family:
  • Belongs to the TBRG1 family.
genes like me logo Genes that share domains with TBRG1: view

Function for TBRG1 Gene

Molecular function for TBRG1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.

Gene Ontology (GO) - Molecular Function for TBRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17110379
genes like me logo Genes that share ontologies with TBRG1: view
genes like me logo Genes that share phenotypes with TBRG1: view

Animal Model Products

CRISPR Products

miRNA for TBRG1 Gene

miRTarBase miRNAs that target TBRG1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBRG1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBRG1 Gene

Localization for TBRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBRG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBRG1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TBRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17110379
genes like me logo Genes that share ontologies with TBRG1: view

Pathways & Interactions for TBRG1 Gene

genes like me logo Genes that share pathways with TBRG1: view

Gene Ontology (GO) - Biological Process for TBRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IMP 17110379
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IMP 17110379
GO:0008285 negative regulation of cell proliferation IMP 17110379
GO:0050821 protein stabilization IMP 17110379
genes like me logo Genes that share ontologies with TBRG1: view

No data available for SIGNOR curated interactions for TBRG1 Gene

Drugs & Compounds for TBRG1 Gene

No Compound Related Data Available

Transcripts for TBRG1 Gene

mRNA/cDNA for TBRG1 Gene

Unigene Clusters for TBRG1 Gene

Transforming growth factor beta regulator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBRG1

Alternative Splicing Database (ASD) splice patterns (SP) for TBRG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6: -
SP7: - - - - - - - - - -
SP8:

Relevant External Links for TBRG1 Gene

GeneLoc Exon Structure for
TBRG1
ECgene alternative splicing isoforms for
TBRG1

Expression for TBRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TBRG1 Gene

This gene is overexpressed in Blymphocyte (61.7) and Placenta (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TBRG1 Gene



Protein tissue co-expression partners for TBRG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBRG1 Gene:

TBRG1

SOURCE GeneReport for Unigene cluster for TBRG1 Gene:

Hs.436410

mRNA Expression by UniProt/SwissProt for TBRG1 Gene:

Q3YBR2-TBRG1_HUMAN
Tissue specificity: Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.

Evidence on tissue expression from TISSUES for TBRG1 Gene

  • Nervous system(4.9)
  • Spleen(4.3)
  • Kidney(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with TBRG1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBRG1 Gene

Orthologs for TBRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBRG1 34 33
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TBRG1 34 33
  • 91.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TBRG1 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbrg1 33
  • 87.93 (n)
mouse
(Mus musculus)
Mammalia Tbrg1 16 34 33
  • 87.77 (n)
oppossum
(Monodelphis domestica)
Mammalia TBRG1 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TBRG1 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbrg1 33
  • 63.07 (n)
Str.7289 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7342 33
zebrafish
(Danio rerio)
Actinopterygii tbrg1 34 33
  • 65.95 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9934 33
fruit fly
(Drosophila melanogaster)
Insecta CG31111 34 33
  • 49.37 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToOne
Species where no ortholog for TBRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBRG1 Gene

ENSEMBL:
Gene Tree for TBRG1 (if available)
TreeFam:
Gene Tree for TBRG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TBRG1: view image

Paralogs for TBRG1 Gene

No data available for Paralogs for TBRG1 Gene

Variants for TBRG1 Gene

Sequence variations from dbSNP and Humsavar for TBRG1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000090925 -- 124,630,680(+) T/C intron_variant
rs1000141555 -- 124,624,184(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000151876 -- 124,634,220(+) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1000719933 -- 124,632,927(+) C/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1000751215 -- 124,632,520(+) T/C 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TBRG1 Gene

Variant ID Type Subtype PubMed ID
nsv1045156 CNV loss 25217958

Variation tolerance for TBRG1 Gene

Gene Damage Index Score: 3.63; 56.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBRG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBRG1 Gene

Disorders for TBRG1 Gene

Additional Disease Information for TBRG1

No disorders were found for TBRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBRG1 Gene

Publications for TBRG1 Gene

  1. A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. (PMID: 17110379) Tompkins VS … Quelle DE (The Journal of biological chemistry 2007) 2 3 4 58
  2. The structure of the FYR domain of transforming growth factor beta regulator 1. (PMID: 20506279) García-Alai MM … Bycroft M (Protein science : a publication of the Protein Society 2010) 3 4 58
  3. Identification of novel ARF binding proteins by two-hybrid screening. (PMID: 16582619) Tompkins V … Quelle DE (Cell cycle (Georgetown, Tex.) 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TBRG1 Gene

Sources for TBRG1 Gene

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