Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RIOX2 Gene

Aliases for RIOX2 Gene

  • Ribosomal Oxygenase 2 2 3 5
  • Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MINA 3 4
  • 60S Ribosomal Protein L27a Histidine Hydroxylase 3 4
  • Histone Lysine Demethylase MINA 3 4
  • MYC Induced Nuclear Antigen 2 3
  • Ribosomal Oxygenase MINA 3 4
  • Nucleolar Protein 52 3 4
  • MINA53 3 4
  • MINA 3 4
  • MDIG 3 4
  • NO52 3 4
  • ROX 3 4
  • Myc-Induced Nuclear Antigen, 53 KDa 3
  • Mineral Dust Induced Gene Protein 3
  • Mineral Dust-Induced Gene Protein 4
  • MYC-Induced Nuclear Antigen 4
  • EC 1.14.11.- 4
  • JMJD10 3

External Ids for RIOX2 Gene

Previous HGNC Symbols for RIOX2 Gene

  • MINA

Summaries for RIOX2 Gene

Entrez Gene Summary for RIOX2 Gene

  • MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

GeneCards Summary for RIOX2 Gene

RIOX2 (Ribosomal Oxygenase 2) is a Protein Coding gene. Diseases associated with RIOX2 include Lung Cancer. Among its related pathways are Validated targets of C-MYC transcriptional activation and Chromatin organization. An important paralog of this gene is RIOX1.

UniProtKB/Swiss-Prot for RIOX2 Gene

  • Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on His-39. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Gene Wiki entry for RIOX2 Gene

Additional gene information for RIOX2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOX2 Gene

Genomics for RIOX2 Gene

GeneHancer (GH) Regulatory Elements for RIOX2 Gene

Promoters and enhancers for RIOX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I097969 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 555.9 +1.0 972 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ATF7 RUNX3 RIOX2 CRYBG3 LOC105373994
GH03I097968 Promoter 0.5 EPDnew 550.8 +3.9 3858 0.1 RIOX2 LOC105373994
GH03I097820 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 10.5 +150.0 149977 3.1 RB1 SIN3A ZNF76 DMAP1 BMI1 ZNF48 YY1 ZNF335 ZNF366 SCRT2 CRYBG3 LOC101929298 RIOX2 LOC105373994
GH03I097910 Enhancer 1.1 Ensembl ENCODE 11.4 +61.4 61386 1.7 HDAC1 PKNOX1 ATF1 FOXA2 ARNT NFRKB TCF12 ZNF766 GATA2 ETV6 RIOX2 CRYBG3 LOC105373994
GH03I097882 Enhancer 0.7 Ensembl ENCODE 15.1 +89.5 89467 0.8 JUND NFIC GATA3 NFIB HMBOX1 FEZF1 RIOX2 LOC105373994 CRYBG3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RIOX2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RIOX2 Gene

Genomic Locations for RIOX2 Gene
chr3:97,941,817-97,972,457
(GRCh38/hg38)
Size:
30,641 bases
Orientation:
Minus strand
chr3:97,660,661-97,691,301
(GRCh37/hg19)

Genomic View for RIOX2 Gene

Genes around RIOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOX2 Gene

Proteins for RIOX2 Gene

  • Protein details for RIOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUF8-RIOX2_HUMAN
    Recommended name:
    Ribosomal oxygenase 2
    Protein Accession:
    Q8IUF8
    Secondary Accessions:
    • D3DN35
    • Q6AHW4
    • Q6SKS0
    • Q8IU69
    • Q8IUF6
    • Q8IUF7
    • Q96C17
    • Q96KB0

    Protein attributes for RIOX2 Gene

    Size:
    465 amino acids
    Molecular mass:
    52800 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH10679.1; Type=Erroneous termination; Positions=431; Note=Translated as Trp.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIOX2 Gene

    Alternative splice isoforms for RIOX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIOX2 Gene

Post-translational modifications for RIOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIOX2 Gene

Domains & Families for RIOX2 Gene

Gene Families for RIOX2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RIOX2 Gene

Suggested Antigen Peptide Sequences for RIOX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUF8

UniProtKB/Swiss-Prot:

RIOX2_HUMAN :
  • Belongs to the ROX family. MINA53 subfamily.
Family:
  • Belongs to the ROX family. MINA53 subfamily.
genes like me logo Genes that share domains with RIOX2: view

Function for RIOX2 Gene

Molecular function for RIOX2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO(2).
UniProtKB/Swiss-Prot Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on His-39. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.

Enzyme Numbers (IUBMB) for RIOX2 Gene

Gene Ontology (GO) - Molecular Function for RIOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0032452 histone demethylase activity TAS --
GO:0032453 histone demethylase activity (H3-K4 specific) IBA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with RIOX2: view
genes like me logo Genes that share phenotypes with RIOX2: view

Animal Models for RIOX2 Gene

MGI Knock Outs for RIOX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIOX2 Gene

Localization for RIOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIOX2 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIOX2 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RIOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IEA,IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RIOX2: view

Pathways & Interactions for RIOX2 Gene

genes like me logo Genes that share pathways with RIOX2: view

Pathways by source for RIOX2 Gene

Gene Ontology (GO) - Biological Process for RIOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006338 chromatin remodeling IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016577 histone demethylation IEA --
genes like me logo Genes that share ontologies with RIOX2: view

No data available for SIGNOR curated interactions for RIOX2 Gene

Drugs & Compounds for RIOX2 Gene

(2) Drugs for RIOX2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Succinic acid Approved Nutra Full agonist, Agonist 0

(1) Additional Compounds for RIOX2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with RIOX2: view

Transcripts for RIOX2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIOX2 Gene

No ASD Table

Relevant External Links for RIOX2 Gene

GeneLoc Exon Structure for
RIOX2
ECgene alternative splicing isoforms for
RIOX2

Expression for RIOX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIOX2 Gene:

RIOX2

mRNA Expression by UniProt/SwissProt for RIOX2 Gene:

Q8IUF8-RIOX2_HUMAN
Tissue specificity: Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.

Evidence on tissue expression from TISSUES for RIOX2 Gene

  • Nervous system(2.9)
  • Lymph node(2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIOX2 Gene

Orthologs for RIOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MINA 33 34
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia MINA 33 34
  • 85.76 (n)
rat
(Rattus norvegicus)
Mammalia Mina 33
  • 82.15 (n)
mouse
(Mus musculus)
Mammalia Mina 33 34
  • 80.93 (n)
Riox2 16
dog
(Canis familiaris)
Mammalia MINA 33 34
  • 80.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MINA 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MINA 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MINA 33 34
  • 70.78 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mina 33
  • 59.19 (n)
Str.7087 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14893 33
zebrafish
(Danio rerio)
Actinopterygii minal 33 34
  • 59.7 (n)
zgc63873 33
fruit fly
(Drosophila melanogaster)
Insecta CG2982 34
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea jmjc-1 34
  • 17 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8544 34
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10438 33
Species where no ortholog for RIOX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOX2 Gene

ENSEMBL:
Gene Tree for RIOX2 (if available)
TreeFam:
Gene Tree for RIOX2 (if available)

Paralogs for RIOX2 Gene

Paralogs for RIOX2 Gene

genes like me logo Genes that share paralogs with RIOX2: view

Variants for RIOX2 Gene

Sequence variations from dbSNP and Humsavar for RIOX2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000068386 -- 97,973,544(-) G/T upstream_transcript_variant
rs1000069027 -- 97,944,780(-) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000323736 -- 97,950,088(-) C/T intron_variant
rs1000490114 -- 97,971,281(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000843127 -- 97,965,609(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RIOX2 Gene

Variant ID Type Subtype PubMed ID
nsv1012322 CNV gain 25217958
nsv1013060 CNV gain 25217958
nsv520553 CNV gain 19592680

Variation tolerance for RIOX2 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.87; 93.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIOX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIOX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIOX2 Gene

Disorders for RIOX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RIOX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search RIOX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RIOX2

genes like me logo Genes that share disorders with RIOX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIOX2 Gene

Publications for RIOX2 Gene

  1. A novel myc target gene, mina53, that is involved in cell proliferation. (PMID: 12091391) Tsuneoka M … Kimura H (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. (PMID: 19502796) Lu Y … Chen F (Cell cycle (Georgetown, Tex.) 2009) 3 4 58
  3. The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. (PMID: 15897898) Zhang Y … Chen F (Oncogene 2005) 3 4 58
  4. Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66. (PMID: 15819408) Eilbracht J … Schmidt-Zachmann MS (European journal of cell biology 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for RIOX2 Gene

Sources for RIOX2 Gene

Content
Loading form....