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Aliases for HIRIP3 Gene

Aliases for HIRIP3 Gene

  • HIRA Interacting Protein 3 2 3 5
  • HIRA-Interacting Protein 3 2 3

External Ids for HIRIP3 Gene

Previous GeneCards Identifiers for HIRIP3 Gene

  • GC16P029153
  • GC16M030326
  • GC16M030002
  • GC16M030041
  • GC16M029911
  • GC16M030005
  • GC16M027665

Summaries for HIRIP3 Gene

Entrez Gene Summary for HIRIP3 Gene

  • The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for HIRIP3 Gene

HIRIP3 (HIRA Interacting Protein 3) is a Protein Coding gene. Diseases associated with HIRIP3 include Velocardiofacial Syndrome.

UniProtKB/Swiss-Prot for HIRIP3 Gene

  • May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.

Gene Wiki entry for HIRIP3 Gene

Additional gene information for HIRIP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIRIP3 Gene

Genomics for HIRIP3 Gene

GeneHancer (GH) Regulatory Elements for HIRIP3 Gene

Promoters and enhancers for HIRIP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J029992 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.5 1512 4.8 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 INO80E HIRIP3 PIR37996 PIR46335 GC16M029996 SRCAP SMG1P5 SETD1A SMG1P2 ENSG00000198106
GH16J029972 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 12.9 +20.9 20879 6.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TAOK2 INO80E SETD1A SRCAP NPIPB12 NPIPB13 ENSG00000260367 ZNF764 BCL7C SMG1P5
GH16J029819 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 +173.5 173522 7.5 HDGF PKNOX1 CLOCK SIN3A ZNF48 YY1 GLIS2 ZNF143 ZFP91 FOS MVP ENSG00000238045 GC16M029840 INO80E ATXN2L SRCAP FBRS ENSG00000260853 RNF40 NPIPB12
GH16J029961 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 +34.0 34049 2.5 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 POLR2B TMEM219 PIR61167 INO80E ENSG00000260853 ENSG00000260367 SRCAP SPNS1 SMG1P5 SMG1P2 CA5AP1
GH16J029803 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.8 +188.0 187993 10.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PRRT2 ENSG00000280607 ENSG00000259952 GC16P029807 GC16P029809 GC16P029961 MAZ PIR38319 PIR43581 PIR52049
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HIRIP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIRIP3 gene promoter:
  • E2F-5
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • AREB6
  • ARP-1
  • RORalpha1
  • Nkx2-5

Genomic Locations for HIRIP3 Gene

Genomic Locations for HIRIP3 Gene
chr16:29,992,321-29,996,436
(GRCh38/hg38)
Size:
4,116 bases
Orientation:
Minus strand
chr16:30,003,645-30,007,757
(GRCh37/hg19)
Size:
4,113 bases
Orientation:
Minus strand

Genomic View for HIRIP3 Gene

Genes around HIRIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIRIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIRIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIRIP3 Gene

Proteins for HIRIP3 Gene

  • Protein details for HIRIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW71-HIRP3_HUMAN
    Recommended name:
    HIRA-interacting protein 3
    Protein Accession:
    Q9BW71
    Secondary Accessions:
    • H3BSR3
    • O75707
    • O75708

    Protein attributes for HIRIP3 Gene

    Size:
    556 amino acids
    Molecular mass:
    61957 Da
    Quaternary structure:
    • Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2.

    Alternative splice isoforms for HIRIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIRIP3 Gene

Post-translational modifications for HIRIP3 Gene

Other Protein References for HIRIP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HIRIP3
  • Boster Bio Antibodies for HIRIP3

No data available for DME Specific Peptides for HIRIP3 Gene

Domains & Families for HIRIP3 Gene

Gene Families for HIRIP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HIRIP3 Gene

Suggested Antigen Peptide Sequences for HIRIP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HIRIP3: view

No data available for UniProtKB/Swiss-Prot for HIRIP3 Gene

Function for HIRIP3 Gene

Molecular function for HIRIP3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.
GENATLAS Biochemistry:
HIRA-interacting protein 3,widely expressed an histone (H2B,H3) binding protein,directly interacting with the WD-repeat protein HIRA

Phenotypes From GWAS Catalog for HIRIP3 Gene

Gene Ontology (GO) - Molecular Function for HIRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9710638
genes like me logo Genes that share ontologies with HIRIP3: view
genes like me logo Genes that share phenotypes with HIRIP3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIRIP3 Gene

Localization for HIRIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIRIP3 Gene

Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIRIP3 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HIRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 17391060
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with HIRIP3: view

Pathways & Interactions for HIRIP3 Gene

SuperPathways for HIRIP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006333 chromatin assembly or disassembly TAS 9710638
genes like me logo Genes that share ontologies with HIRIP3: view

No data available for Pathways by source and SIGNOR curated interactions for HIRIP3 Gene

Drugs & Compounds for HIRIP3 Gene

(1) Additional Compounds for HIRIP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Docosanoyl-CoA
  • Behenoyl-CoA
  • Behenoyl-coenzyme A
genes like me logo Genes that share compounds with HIRIP3: view

Transcripts for HIRIP3 Gene

mRNA/cDNA for HIRIP3 Gene

Unigene Clusters for HIRIP3 Gene

HIRA interacting protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIRIP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5:
SP6: - -
SP7: - - - - - - -
SP8: - - - - -
SP9:
SP10: -

Relevant External Links for HIRIP3 Gene

GeneLoc Exon Structure for
HIRIP3
ECgene alternative splicing isoforms for
HIRIP3

Expression for HIRIP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIRIP3 Gene

Protein differential expression in normal tissues from HIPED for HIRIP3 Gene

This gene is overexpressed in Cervix (38.7) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIRIP3 Gene



Protein tissue co-expression partners for HIRIP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HIRIP3 Gene:

HIRIP3

SOURCE GeneReport for Unigene cluster for HIRIP3 Gene:

Hs.567370

mRNA Expression by UniProt/SwissProt for HIRIP3 Gene:

Q9BW71-HIRP3_HUMAN
Tissue specificity: Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart.

Evidence on tissue expression from TISSUES for HIRIP3 Gene

  • Liver(4.3)
  • Blood(4.2)
  • Skin(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with HIRIP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIRIP3 Gene

Orthologs for HIRIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIRIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIRIP3 34 33
  • 99.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HIRIP3 34 33
  • 82.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HIRIP3 34 33
  • 80.17 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hirip3 33
  • 73.83 (n)
mouse
(Mus musculus)
Mammalia Hirip3 16 34 33
  • 70.86 (n)
oppossum
(Monodelphis domestica)
Mammalia HIRIP3 34
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIRIP3 34
  • 28 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hirip3 34
  • 29 (a)
OneToOne
Species where no ortholog for HIRIP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIRIP3 Gene

ENSEMBL:
Gene Tree for HIRIP3 (if available)
TreeFam:
Gene Tree for HIRIP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HIRIP3: view image

Paralogs for HIRIP3 Gene

No data available for Paralogs for HIRIP3 Gene

Variants for HIRIP3 Gene

Sequence variations from dbSNP and Humsavar for HIRIP3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000638423 -- 29,994,476(-) A/G coding_sequence_variant, intron_variant, synonymous_variant
rs1001278787 -- 29,998,006(-) A/G upstream_transcript_variant
rs1001640977 -- 29,995,506(-) G/A intron_variant
rs1002589261 -- 29,991,940(-) C/G downstream_transcript_variant
rs1003059588 -- 29,995,361(-) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for HIRIP3 Gene

Variant ID Type Subtype PubMed ID
esv3638378 CNV loss 21293372
esv997840 CNV deletion 20482838

Variation tolerance for HIRIP3 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIRIP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIRIP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIRIP3 Gene

Disorders for HIRIP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HIRIP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
velocardiofacial syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HIRIP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HIRIP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HIRIP3 Gene

Publications for HIRIP3 Gene

  1. Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. (PMID: 9710638) Lorain S … Lipinski M (Molecular and cellular biology 1998) 2 3 4 22 58
  2. HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2. (PMID: 17391060) Assrir N … Lipinski M (Biological chemistry 2007) 3 4 22 58
  3. Association and mutation analyses of 16p11.2 autism candidate genes. (PMID: 19242545) Kumar RA … Christian SL (PloS one 2009) 3 44 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for HIRIP3 Gene

Sources for HIRIP3 Gene

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