Aliases for GJA10 Gene
External Ids for GJA10 Gene
Previous GeneCards Identifiers for GJA10 Gene
Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GJA10 Gene
GJA10 (Gap Junction Protein Alpha 10) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include gap junction channel activity. An important paralog of this gene is GJA9.
UniProtKB/Swiss-Prot for GJA10 Gene
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity).
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).