Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTF2 Gene

Aliases for TTF2 Gene

  • Transcription Termination Factor 2 2 3 3 5
  • Transcription Release Factor 2 2 3 4
  • Transcription Termination Factor, RNA Polymerase II 2 3
  • RNA Polymerase II Termination Factor 3 4
  • Zinc Finger, GRF-Type Containing 6 2 3
  • Lodestar Homolog 3 4
  • HuF2 3 4
  • F2 3 4
  • Lodestar Protein 3
  • Human Factor 2 3
  • EC 3.6.4.- 4
  • ZGRF6 3

External Ids for TTF2 Gene

Previous GeneCards Identifiers for TTF2 Gene

  • GC01P118062
  • GC01P116441
  • GC01P116750
  • GC01P116949
  • GC01P117314
  • GC01P117404
  • GC01P117602
  • GC01P115461

Summaries for TTF2 Gene

Entrez Gene Summary for TTF2 Gene

  • This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TTF2 Gene

TTF2 (Transcription Termination Factor 2) is a Protein Coding gene. Diseases associated with TTF2 include Sexual Sadism and Narcissistic Personality Disorder. Among its related pathways are Aldosterone synthesis and secretion and Human Thyroid Stimulating Hormone (TSH) signaling pathway. Gene Ontology (GO) annotations related to this gene include hydrolase activity and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot for TTF2 Gene

  • DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

Gene Wiki entry for TTF2 Gene

Additional gene information for TTF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTF2 Gene

Genomics for TTF2 Gene

GeneHancer (GH) Regulatory Elements for TTF2 Gene

Promoters and enhancers for TTF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J117058 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 677.4 +0.4 375 4.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 TTF2 LOC101929099 WDR3 GDAP2 MAN1A2 ATP1A1-AS1 CD101 MIR942
GH01J116736 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -321.2 -321232 4.6 SMAD1 ARNT BMI1 BATF IRF4 RAD21 RFX5 ZNF335 ZNF121 E2F8 TTF2 LOC101929099 CD101 IGSF3 ATP1A1 CD2 NEFHP1 GC01M116740 GAPDHP64
GH01J117076 Enhancer 1 FANTOM5 ENCODE 12.8 +17.0 17026 1.8 ZBTB21 JUN ZSCAN4 INSM2 CEBPG RFX5 HIC1 FOSL1 ZNF366 NFATC1 TTF2 TRIM45 CD101 MIR942
GH01J117120 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5 +61.8 61840 2.9 PKNOX1 SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 FOS SP3 CEBPZ TRIM45 WDR3 ATP1A1-AS1 VTCN1 GDAP2 ENSG00000212266 TTF2 PIR35685
GH01J116721 Enhancer 0.7 ENCODE 11.1 -337.7 -337745 1.3 MEIS2 CTCF PKNOX1 ARNT ZBTB40 ZNF316 TRIM24 NFE2 MAFK MAFG C1orf137 LOC101929099 TTF2 CD2 MIR320B1 IGSF3 CD101 GAPDHP64 GC01M116740
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTF2 gene promoter:
  • AREB6
  • AML1a
  • RSRFC4
  • PPAR-alpha
  • ATF
  • GATA-2
  • Arnt
  • E2F
  • E2F-1
  • E2F-2

Genomic Locations for TTF2 Gene

Genomic Locations for TTF2 Gene
47,166 bases
Plus strand
47,151 bases
Plus strand

Genomic View for TTF2 Gene

Genes around TTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTF2 Gene

Proteins for TTF2 Gene

  • Protein details for TTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription termination factor 2
    Protein Accession:
    Secondary Accessions:
    • A8K4Q2
    • O75921
    • Q5T2K7
    • Q5VVU8
    • Q8N6I8

    Protein attributes for TTF2 Gene

    1162 amino acids
    Molecular mass:
    129588 Da
    Quaternary structure:
    • Interacts with CDC5L. Part of the spliceosome.

    Alternative splice isoforms for TTF2 Gene


neXtProt entry for TTF2 Gene

Post-translational modifications for TTF2 Gene

  • Ubiquitination at posLast=11091109, posLast=814814, and posLast=567567
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTF2 Gene

Domains & Families for TTF2 Gene

Gene Families for TTF2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TTF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SNF2/RAD54 helicase family.
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with TTF2: view

Function for TTF2 Gene

Molecular function for TTF2 Gene

UniProtKB/Swiss-Prot Function:
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for TTF2 Gene

Phenotypes From GWAS Catalog for TTF2 Gene

Gene Ontology (GO) - Molecular Function for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 12927788
GO:0005524 ATP binding IEA --
GO:0008094 DNA-dependent ATPase activity TAS 9748214
genes like me logo Genes that share ontologies with TTF2: view
genes like me logo Genes that share phenotypes with TTF2: view

Animal Model Products

miRNA for TTF2 Gene

miRTarBase miRNAs that target TTF2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTF2 Gene

Localization for TTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTF2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTF2 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0008023 transcription elongation factor complex TAS 9748214
genes like me logo Genes that share ontologies with TTF2: view

Pathways & Interactions for TTF2 Gene

genes like me logo Genes that share pathways with TTF2: view

Pathways by source for TTF2 Gene

1 KEGG pathway for TTF2 Gene

Gene Ontology (GO) - Biological Process for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006353 DNA-templated transcription, termination TAS 9748214
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006369 termination of RNA polymerase II transcription TAS 9748214
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with TTF2: view

No data available for SIGNOR curated interactions for TTF2 Gene

Drugs & Compounds for TTF2 Gene

(35) Drugs for TTF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(19) Additional Compounds for TTF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TTF2: view

Transcripts for TTF2 Gene

Unigene Clusters for TTF2 Gene

Transcription termination factor, RNA polymerase II:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: -
SP2: -
SP3: -

Relevant External Links for TTF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTF2 Gene

Protein differential expression in normal tissues from HIPED for TTF2 Gene

This gene is overexpressed in Plasma (42.3), Monocytes (16.2), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTF2 Gene

Protein tissue co-expression partners for TTF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TTF2 Gene:


SOURCE GeneReport for Unigene cluster for TTF2 Gene:


Evidence on tissue expression from TISSUES for TTF2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TTF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTF2 Gene

Orthologs for TTF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTF2 34 33
  • 99.54 (n)
(Bos Taurus)
Mammalia TTF2 34 33
  • 83.94 (n)
(Canis familiaris)
Mammalia TTF2 34 33
  • 80.98 (n)
(Mus musculus)
Mammalia Ttf2 16 34 33
  • 78.07 (n)
(Rattus norvegicus)
Mammalia Ttf2 33
  • 78.03 (n)
(Monodelphis domestica)
Mammalia TTF2 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia TTF2 34
  • 41 (a)
(Gallus gallus)
Aves TTF2 34 33
  • 61.06 (n)
(Anolis carolinensis)
Reptilia TTF2 34
  • 49 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16195 33
(Danio rerio)
Actinopterygii si:ch1073-303l5.1 33
  • 58.57 (n)
TTF2 34
  • 50 (a)
Dr.29408 33
fruit fly
(Drosophila melanogaster)
Insecta lds 34 35
  • 32 (a)
CG10445 34 35
  • 24 (a)
(Caenorhabditis elegans)
Secernentea F54E12.2 34 33
  • 48.06 (n)
F59A7.8 34 35
  • 31 (a)
T23H2.3 34
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD16 34
  • 27 (a)
ULS1 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Cin.10555 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10555 33
Species where no ortholog for TTF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TTF2 Gene

Gene Tree for TTF2 (if available)
Gene Tree for TTF2 (if available)
Evolutionary constrained regions (ECRs) for TTF2: view image

Paralogs for TTF2 Gene

No data available for Paralogs for TTF2 Gene

Variants for TTF2 Gene

Sequence variations from dbSNP and Humsavar for TTF2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000032946 -- 117,106,272(+) T/A/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000039347 -- 117,067,351(+) G/A intron_variant
rs1000284773 -- 117,087,376(+) C/G intron_variant
rs1000405612 -- 117,106,530(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000467403 -- 117,081,370(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTF2 Gene

Variant ID Type Subtype PubMed ID
nsv1009706 CNV gain 25217958
nsv1127019 CNV deletion 24896259

Variation tolerance for TTF2 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTF2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTF2 Gene

Disorders for TTF2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TTF2 Gene - From: HGMD, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TTF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TTF2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TTF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTF2 Gene

Publications for TTF2 Gene

  1. Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer. (PMID: 10455150) Hara R … Sancar A (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. (PMID: 9748214) Liu M … Price DH (The Journal of biological chemistry 1998) 2 3 4 22 58
  3. Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. (PMID: 15125840) Jiang Y … Price DH (Molecular cell 2004) 3 4 22 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TTF2 Gene

Sources for TTF2 Gene

Loading form....