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Aliases for MAK16 Gene

Aliases for MAK16 Gene

  • MAK16 Homolog 2 3 5
  • RNA Binding Motif Protein 13 2 3
  • RBM13 3 4
  • NNP78 3 4
  • MAK16 Homolog (S. Cerevisiae) 2
  • Protein MAK16 Homolog 3
  • RNA Binding Protein 3
  • Protein RBM13 4
  • MAK16L 3

External Ids for MAK16 Gene

Previous HGNC Symbols for MAK16 Gene

  • RBM13

Previous GeneCards Identifiers for MAK16 Gene

  • GC08P033342
  • GC08P031874

Summaries for MAK16 Gene

GeneCards Summary for MAK16 Gene

MAK16 (MAK16 Homolog) is a Protein Coding gene. Diseases associated with MAK16 include Mental Retardation, Autosomal Recessive 39.

Gene Wiki entry for MAK16 Gene

Additional gene information for MAK16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAK16 Gene

Genomics for MAK16 Gene

GeneHancer (GH) Regulatory Elements for MAK16 Gene

Promoters and enhancers for MAK16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J033483 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 370 2.8 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 MAK16 FUT10 TTI2 GC08P033513
GH08J033511 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.7 +28.8 28842 3.6 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF548 SP3 TTI2 GC08P033513 SNORD13 FUT10 MAK16 RNF122
GH08J033574 Enhancer 0.8 FANTOM5 Ensembl 11.2 +90.0 90033 0.8 GTF2F1 NFATC3 SMAD5 E4F1 MTA3 POLR2B POLR2A NFYB MGA SUPT5H FUT10 LOC100630919 TTI2 SNORD13 RPL10P18 ENSG00000252505 MAK16 RNF122 RN7SL621P
GH08J033580 Enhancer 0.8 ENCODE 10.9 +96.8 96767 1.6 ELF3 ARID4B DMAP1 ZNF48 ZSCAN9 ZNF614 CREM THAP11 MIXL1 HMG20B RN7SL621P GC08P033581 FUT10 LOC100630919 SNORD13 TTI2 ENSG00000252505 RPL10P18 MAK16 RNF122
GH08J033433 Enhancer 0.3 FANTOM5 12.7 -50.7 -50650 0.4 MAK16 ENSG00000252505 RPL10P18 FUT10 TTI2 LOC100507379 PIR51386
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAK16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAK16 gene promoter:
  • c-Ets-1
  • HFH-1
  • YY1
  • Nkx6-1
  • FOXF2
  • Elk-1
  • FOXO4
  • LCR-F1
  • MEF-2A
  • MEF-2

Genomic Locations for MAK16 Gene

Genomic Locations for MAK16 Gene
16,511 bases
Plus strand
16,511 bases
Plus strand

Genomic View for MAK16 Gene

Genes around MAK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAK16 Gene

Proteins for MAK16 Gene

  • Protein details for MAK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MAK16 homolog
    Protein Accession:
    Secondary Accessions:
    • B2RB44
    • Q5U5T1
    • Q86UC4
    • Q96SY6

    Protein attributes for MAK16 Gene

    300 amino acids
    Molecular mass:
    35369 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAK16 Gene

Post-translational modifications for MAK16 Gene

  • Ubiquitination at isoforms=115
  • Modification sites at PhosphoSitePlus

Other Protein References for MAK16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAK16 Gene

Domains & Families for MAK16 Gene

Gene Families for MAK16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAK16 Gene

Suggested Antigen Peptide Sequences for MAK16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MAK16 family.
  • Belongs to the MAK16 family.
genes like me logo Genes that share domains with MAK16: view

Function for MAK16 Gene

Gene Ontology (GO) - Molecular Function for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with MAK16: view
genes like me logo Genes that share phenotypes with MAK16: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAK16 Gene

Localization for MAK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAK16 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAK16 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IBA,IDA --
GO:0030687 preribosome, large subunit precursor IBA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with MAK16: view

Pathways & Interactions for MAK16 Gene

SuperPathways for MAK16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IBA --
GO:0000470 maturation of LSU-rRNA IBA --
genes like me logo Genes that share ontologies with MAK16: view

No data available for Pathways by source and SIGNOR curated interactions for MAK16 Gene

Drugs & Compounds for MAK16 Gene

No Compound Related Data Available

Transcripts for MAK16 Gene

mRNA/cDNA for MAK16 Gene

Unigene Clusters for MAK16 Gene

MAK16 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAK16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: - -
SP3: -
SP5: -

Relevant External Links for MAK16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAK16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAK16 Gene

This gene is overexpressed in Fetal ovary (14.4), Liver (13.7), Adrenal (10.5), Peripheral blood mononuclear cells (10.3), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAK16 Gene

Protein tissue co-expression partners for MAK16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAK16 Gene:


SOURCE GeneReport for Unigene cluster for MAK16 Gene:


Evidence on tissue expression from TISSUES for MAK16 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with MAK16: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAK16 Gene

Orthologs for MAK16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAK16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAK16 34 33
  • 99.33 (n)
(Canis familiaris)
Mammalia MAK16 34 33
  • 91.16 (n)
(Bos Taurus)
Mammalia MAK16 34 33
  • 90.94 (n)
(Mus musculus)
Mammalia Mak16 16 34 33
  • 86.6 (n)
(Rattus norvegicus)
Mammalia Mak16 33
  • 86.58 (n)
(Ornithorhynchus anatinus)
Mammalia MAK16 34
  • 79 (a)
(Monodelphis domestica)
Mammalia MAK16 34
  • 78 (a)
(Gallus gallus)
Aves MAK16 34 33
  • 74.89 (n)
(Anolis carolinensis)
Reptilia MAK16 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mak16 33
  • 74.05 (n)
MGC75652 33
African clawed frog
(Xenopus laevis)
Amphibia mak16l-prov 33
(Danio rerio)
Actinopterygii mak16 34 33
  • 69.82 (n)
mak16l 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000514 33
  • 61.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rbm13 34
  • 44 (a)
(Caenorhabditis elegans)
Secernentea C16A3.6 34 33
  • 55.97 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04037g 33
  • 56.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK16 36 34 33
  • 54.81 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR349W 33
  • 53.55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G23280 33
  • 54.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
Cin.4373 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mak16 33
  • 54.3 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04150 33
  • 53.38 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4373 33
Species where no ortholog for MAK16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAK16 Gene

Gene Tree for MAK16 (if available)
Gene Tree for MAK16 (if available)
Evolutionary constrained regions (ECRs) for MAK16: view image

Paralogs for MAK16 Gene

No data available for Paralogs for MAK16 Gene

Variants for MAK16 Gene

Sequence variations from dbSNP and Humsavar for MAK16 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs398122367 pathogenic, Mental retardation, autosomal recessive 39 33,500,443(+) A/T 3_prime_UTR_variant
rs3736497 uncertain-significance, not specified 33,500,476(+) A/C 3_prime_UTR_variant
rs1000107618 -- 33,492,491(+) A/G intron_variant
rs1000497496 -- 33,484,529(+) T/A upstream_transcript_variant
rs1000609111 -- 33,497,389(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAK16 Gene

Variant ID Type Subtype PubMed ID
esv3576539 CNV gain 25503493
nsv1117819 CNV deletion 24896259

Variation tolerance for MAK16 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAK16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAK16 Gene

Disorders for MAK16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAK16 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal recessive 39
  • mrt39
- elite association - COSMIC cancer census association via MalaCards
Search MAK16 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAK16

genes like me logo Genes that share disorders with MAK16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAK16 Gene

Publications for MAK16 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen JS … Lamond AI (Current biology : CB 2002) 3 4 58
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58

Products for MAK16 Gene

Sources for MAK16 Gene

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