Aliases for SGIP1 Gene
External Ids for SGIP1 Gene
Previous GeneCards Identifiers for SGIP1 Gene
SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SGIP1 Gene
SGIP1 (SH3 Domain GRB2 Like Endophilin Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Clathrin-mediated endocytosis and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include microtubule binding and phospholipid binding. An important paralog of this gene is FCHO2.
UniProtKB/Swiss-Prot for SGIP1 Gene
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.