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Aliases for MEX3B Gene

Aliases for MEX3B Gene

  • Mex-3 RNA Binding Family Member B 2 3 5
  • Ring Finger And KH Domain Containing 3 2 3
  • RING Finger Protein 195 3 4
  • RNF195 3 4
  • RKHD3 3 4
  • RING Finger And KH Domain-Containing Protein 3 4
  • Mex-3 Homolog B (C. Elegans) 2
  • RNA-Binding Protein MEX3B 3
  • KIAA2009 4
  • MEX-3B 3

External Ids for MEX3B Gene

Previous HGNC Symbols for MEX3B Gene

  • RKHD3

Previous GeneCards Identifiers for MEX3B Gene

  • GC15M080122
  • GC15M082334
  • GC15M059092

Summaries for MEX3B Gene

Entrez Gene Summary for MEX3B Gene

  • This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]

GeneCards Summary for MEX3B Gene

MEX3B (Mex-3 RNA Binding Family Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is MEX3D.

UniProtKB/Swiss-Prot for MEX3B Gene

  • RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Gene Wiki entry for MEX3B Gene

Additional gene information for MEX3B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3B Gene

Genomics for MEX3B Gene

GeneHancer (GH) Regulatory Elements for MEX3B Gene

Promoters and enhancers for MEX3B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J082043 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 659.4 +0.1 72 5.7 PKNOX1 CLOCK ARNT SIN3A ZNF2 YY1 POLR2B ZNF766 CBX5 ZNF143 MEX3B C15orf40 ENSG00000259445 LOC105370923
GH15J081942 Enhancer 0.9 ENCODE 11.7 +103.8 103768 0.2 HDAC1 ATF1 PKNOX1 ARNT CHAMP1 TCF12 ZNF766 SIRT6 ETV6 ATF7 WHAMM GOLGA6L9 MEX3B RPL9P9 GC15P081965 LOC102724001 GC15P081908
GH15J081944 Enhancer 0.9 ENCODE 11.7 +101.0 101027 0.9 ATF1 ARNT TCF12 ZNF766 GATA2 ATF7 NCOA1 ZNF592 MBD2 MEF2D MEX3B LOC102724001 GC15P081965 GC15P081908
GH15J081951 Enhancer 0.9 ENCODE 11.4 +95.0 95048 0.2 PKNOX1 ZNF133 FEZF1 ZNF2 TCF12 ZNF213 KLF7 SP3 NCOA1 TSHZ1 MEX3B ENSG00000259442 GC15P081965 LOC102724001 GC15P081908
GH15J081940 Enhancer 0.8 ENCODE 11.7 +105.3 105259 0 HDAC1 PKNOX1 FEZF1 TCF12 ZNF366 ATF7 ZNF362 OVOL3 TSHZ1 ZEB2 MEX3B GC15P081965 LOC102724001 GC15P081908
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEX3B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEX3B gene promoter:
  • Arnt
  • AhR
  • Pax-5
  • p300
  • Pax-2
  • Pax-2a
  • c-Myc
  • Max1
  • HOXA9
  • HOXA9B

Genomic Locations for MEX3B Gene

Genomic Locations for MEX3B Gene
4,366 bases
Minus strand
4,364 bases
Minus strand

Genomic View for MEX3B Gene

Genes around MEX3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3B Gene

Proteins for MEX3B Gene

  • Protein details for MEX3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein MEX3B
    Protein Accession:
    Secondary Accessions:
    • Q4G0W1
    • Q8IVG2
    • Q9H0J0

    Protein attributes for MEX3B Gene

    569 amino acids
    Molecular mass:
    58832 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC23105.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MEX3B Gene


neXtProt entry for MEX3B Gene

Post-translational modifications for MEX3B Gene

  • Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEX3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3B Gene

Domains & Families for MEX3B Gene

Gene Families for MEX3B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEX3B Gene

Suggested Antigen Peptide Sequences for MEX3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Binds RNA through its KH domains.
  • Binds RNA through its KH domains.
genes like me logo Genes that share domains with MEX3B: view

Function for MEX3B Gene

Molecular function for MEX3B Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Phenotypes From GWAS Catalog for MEX3B Gene

Gene Ontology (GO) - Molecular Function for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0003727 single-stranded RNA binding IBA --
GO:0005509 calcium ion binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MEX3B: view
genes like me logo Genes that share phenotypes with MEX3B: view

Animal Models for MEX3B Gene

MGI Knock Outs for MEX3B:

Animal Model Products

miRNA for MEX3B Gene

miRTarBase miRNAs that target MEX3B

Clone Products

  • Addgene plasmids for MEX3B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEX3B Gene

Localization for MEX3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3B Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEX3B gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MEX3B: view

Pathways & Interactions for MEX3B Gene

SuperPathways for MEX3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0017148 negative regulation of translation IBA --
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with MEX3B: view

No data available for Pathways by source and SIGNOR curated interactions for MEX3B Gene

Drugs & Compounds for MEX3B Gene

No Compound Related Data Available

Transcripts for MEX3B Gene

mRNA/cDNA for MEX3B Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEX3B Gene

Mex-3 homolog B (C. elegans):
Representative Sequences:

Clone Products

  • Addgene plasmids for MEX3B

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3B Gene

No ASD Table

Relevant External Links for MEX3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEX3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEX3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3B Gene

This gene is overexpressed in Testis (x17.0).

Protein differential expression in normal tissues from HIPED for MEX3B Gene

This gene is overexpressed in Platelet (44.1) and Saliva (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEX3B Gene

Protein tissue co-expression partners for MEX3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEX3B Gene:


SOURCE GeneReport for Unigene cluster for MEX3B Gene:


mRNA Expression by UniProt/SwissProt for MEX3B Gene:

Tissue specificity: Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.

Evidence on tissue expression from TISSUES for MEX3B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MEX3B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MEX3B Gene

Orthologs for MEX3B Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MEX3B 34 33
  • 99.06 (n)
(Canis familiaris)
Mammalia MEX3B 34 33
  • 91.14 (n)
(Bos Taurus)
Mammalia MEX3B 34 33
  • 89.05 (n)
(Mus musculus)
Mammalia Mex3b 16 34 33
  • 88.85 (n)
(Rattus norvegicus)
Mammalia Mex3b 33
  • 88.67 (n)
(Monodelphis domestica)
Mammalia MEX3B 34
  • 85 (a)
(Anolis carolinensis)
Reptilia MEX3B 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3b 33
  • 74.84 (n)
(Danio rerio)
Actinopterygii mex3b 34 33
  • 73.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11360 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea mex-3 34
  • 35 (a)
Species where no ortholog for MEX3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3B Gene

Gene Tree for MEX3B (if available)
Gene Tree for MEX3B (if available)
Evolutionary constrained regions (ECRs) for MEX3B: view image

Paralogs for MEX3B Gene

Paralogs for MEX3B Gene

(3) SIMAP similar genes for MEX3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MEX3B: view

Variants for MEX3B Gene

Sequence variations from dbSNP and Humsavar for MEX3B Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000524415 -- 82,041,723(-) T/G downstream_transcript_variant
rs1000819819 -- 82,046,298(-) GAGAGAGAG/GAGAGAG upstream_transcript_variant
rs1001077648 -- 82,044,880(-) G/A intron_variant
rs1001238891 -- 82,045,121(-) C/G intron_variant
rs1002087386 -- 82,047,021(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MEX3B Gene

Variant ID Type Subtype PubMed ID
esv2422504 CNV duplication 17116639
nsv1070287 CNV deletion 25765185
nsv827415 CNV gain 20364138
nsv833067 CNV gain+loss 17160897

Variation tolerance for MEX3B Gene

Residual Variation Intolerance Score: 5.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEX3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3B Gene

Disorders for MEX3B Gene

Additional Disease Information for MEX3B

No disorders were found for MEX3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEX3B Gene

Publications for MEX3B Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K … Billaud M (Nucleic acids research 2007) 2 3 4 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PMID: 19079261) Willer CJ … Genetic Investigation of ANthropometric Traits Consortium (Nature genetics 2009) 3 44 58
  4. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PMID: 18779327) Courchet J … Billaud M (The Journal of biological chemistry 2008) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MEX3B Gene

Sources for MEX3B Gene

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