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Aliases for UTP15 Gene

Aliases for UTP15 Gene

  • UTP15, Small Subunit Processome Component 2 3 5
  • UTP15 SSU Processome Component 2 3
  • UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog (S. Cerevisiae) 2
  • UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast) 2
  • U3 Small Nucleolar RNA-Associated Protein 15 Homolog 3
  • UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog 3
  • Src-Associated Protein SAW 3
  • NET21 3

External Ids for UTP15 Gene

Previous GeneCards Identifiers for UTP15 Gene

  • GC05P072898
  • GC05P068067
  • GC05P072861

Summaries for UTP15 Gene

GeneCards Summary for UTP15 Gene

UTP15 (UTP15, Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include snoRNA binding.

UniProtKB/Swiss-Prot for UTP15 Gene

  • Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

Gene Wiki entry for UTP15 Gene

Additional gene information for UTP15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP15 Gene

Genomics for UTP15 Gene

GeneHancer (GH) Regulatory Elements for UTP15 Gene

Promoters and enhancers for UTP15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J073563 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 663.8 +0.1 130 3.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B UTP15 ANKRA2 ARHGEF28
GH05J073623 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 22.2 +60.5 60525 4.9 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF213 SP3 SP5 MXD4 ARHGEF28 UTP15 ANKRA2 LOC102725145 TNPO1
GH05J072846 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.1 -716.8 -716779 4.1 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 TNPO1 ENSG00000249085 FCHO2 UTP15 ANKRA2 RPL7P22 MRPS27 GC05P072869
GH05J072815 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.1 -748.1 -748087 4.7 SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B ZNF766 ZNF213 ZNF143 ENSG00000249085 GC05M072783 TNPO1 UTP15 FCHO2 ANKRA2 RPL7P22 MRPS27 ENSG00000272081 GC05P072869
GH05J073541 Enhancer 1 Ensembl ENCODE 25.9 -23.5 -23493 2.7 ELF3 FOXA2 ZSCAN4 ZNF48 RARA ZNF366 FOS CREM IKZF2 ELF1 UTP15 ANKRA2 LINC01386 ARHGEF28 FUNDC2P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UTP15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UTP15 gene promoter:
  • POU3F2 (N-Oct-5b)
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • c-Jun
  • ATF-2
  • AML1a

Genomic Locations for UTP15 Gene

Genomic Locations for UTP15 Gene
17,935 bases
Plus strand
16,527 bases
Plus strand

Genomic View for UTP15 Gene

Genes around UTP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP15 Gene

Proteins for UTP15 Gene

  • Protein details for UTP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar RNA-associated protein 15 homolog
    Protein Accession:
    Secondary Accessions:
    • B4DU75
    • B4DXK8
    • Q6IA60
    • Q96E08
    • Q9H9F8

    Protein attributes for UTP15 Gene

    518 amino acids
    Molecular mass:
    58415 Da
    Quaternary structure:
    • Interacts directly with UTP4 and WDR43 (PubMed:24219289). May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75 (PubMed:17699751, PubMed:22916032).
    • Sequence=BAB14271.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85020.1; Type=Frameshift; Positions=489; Evidence={ECO:0000305};

    Alternative splice isoforms for UTP15 Gene


neXtProt entry for UTP15 Gene

Post-translational modifications for UTP15 Gene

  • Ubiquitination at isoforms=2, 3398, isoforms=3155, isoforms=380, and isoforms=36
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UTP15 Gene

Domains & Families for UTP15 Gene

Gene Families for UTP15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UTP15: view

No data available for UniProtKB/Swiss-Prot for UTP15 Gene

Function for UTP15 Gene

Molecular function for UTP15 Gene

UniProtKB/Swiss-Prot Function:
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

Phenotypes From GWAS Catalog for UTP15 Gene

Gene Ontology (GO) - Molecular Function for UTP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 22916032
genes like me logo Genes that share ontologies with UTP15: view
genes like me logo Genes that share phenotypes with UTP15: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP15 Gene

Localization for UTP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP15 Gene

Nucleus, nucleolus. Note=Found predominantly at the fibrillar center. {ECO:0000269 PubMed:24219289}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP15 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytosol 4
mitochondrion 2
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UTP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA 24219289
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 24219289
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with UTP15: view

Pathways & Interactions for UTP15 Gene

genes like me logo Genes that share pathways with UTP15: view

Gene Ontology (GO) - Biological Process for UTP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
GO:0045943 positive regulation of transcription by RNA polymerase I IMP 17699751
genes like me logo Genes that share ontologies with UTP15: view

No data available for SIGNOR curated interactions for UTP15 Gene

Drugs & Compounds for UTP15 Gene

No Compound Related Data Available

Transcripts for UTP15 Gene

Unigene Clusters for UTP15 Gene

UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - -
SP5: -

Relevant External Links for UTP15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTP15 Gene

Protein differential expression in normal tissues from HIPED for UTP15 Gene

This gene is overexpressed in Lung (15.8), Tlymphocyte (9.0), Spinal cord (6.8), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UTP15 Gene

Protein tissue co-expression partners for UTP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UTP15 Gene:


SOURCE GeneReport for Unigene cluster for UTP15 Gene:

genes like me logo Genes that share expression patterns with UTP15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP15 Gene

Orthologs for UTP15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UTP15 34 33
  • 99.68 (n)
(Bos Taurus)
Mammalia UTP15 34 33
  • 92.6 (n)
(Canis familiaris)
Mammalia UTP15 34 33
  • 89.95 (n)
(Rattus norvegicus)
Mammalia Utp15 33
  • 87.29 (n)
(Mus musculus)
Mammalia Utp15 16 34 33
  • 86.06 (n)
(Monodelphis domestica)
Mammalia UTP15 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia UTP15 34
  • 73 (a)
(Gallus gallus)
Aves UTP15 34 33
  • 69.54 (n)
(Anolis carolinensis)
Reptilia UTP15 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia utp15 33
  • 67.4 (n)
Str.15637 33
(Danio rerio)
Actinopterygii utp15 34 33
  • 61.59 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.428 33
fruit fly
(Drosophila melanogaster)
Insecta CG3071 34 33
  • 46.44 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002088 33
  • 46.42 (n)
(Caenorhabditis elegans)
Secernentea Y23H5B.5 34
  • 27 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13772g 33
  • 45.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP15 36 34 33
  • 45.29 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL044C 33
  • 45.17 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SWA1 33
  • 43.57 (n)
(Oryza sativa)
Liliopsida Os07g0224900 33
  • 43.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp15 33
  • 46.61 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09843 33
  • 41.34 (n)
Species where no ortholog for UTP15 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP15 Gene

Gene Tree for UTP15 (if available)
Gene Tree for UTP15 (if available)
Evolutionary constrained regions (ECRs) for UTP15: view image

Paralogs for UTP15 Gene

(1) SIMAP similar genes for UTP15 Gene using alignment to 5 proteins:

  • B4DU75_HUMAN
  • D6RF65_HUMAN
  • H0Y8P4_HUMAN
genes like me logo Genes that share paralogs with UTP15: view

No data available for Paralogs for UTP15 Gene

Variants for UTP15 Gene

Sequence variations from dbSNP and Humsavar for UTP15 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000107909 -- 73,580,753(+) A/G 3_prime_UTR_variant
rs1000120750 -- 73,564,025(+) T/G upstream_transcript_variant
rs1000218021 -- 73,573,409(+) G/A intron_variant
rs1000316267 -- 73,565,931(+) C/G 5_prime_UTR_variant, intron_variant
rs1000327010 -- 73,573,654(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UTP15 Gene

Variant ID Type Subtype PubMed ID
esv3605417 CNV loss 21293372
nsv830346 CNV loss 17160897
nsv830347 CNV gain 17160897

Variation tolerance for UTP15 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP15 Gene

Disorders for UTP15 Gene

Additional Disease Information for UTP15

No disorders were found for UTP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP15 Gene

Publications for UTP15 Gene

  1. Interaction, mobility, and phosphorylation of human orthologues of WD repeat-containing components of the yeast SSU processome t-UTP sub-complex. (PMID: 24219289) Sato M … Horigome T (Biochemistry and cell biology = Biochimie et biologie cellulaire 2013) 2 3 4 58
  2. Dynamics of WD-repeat containing proteins in SSU processome components. (PMID: 24754225) Wada K … Horigome T (Biochemistry and cell biology = Biochimie et biologie cellulaire 2014) 2 3 58
  3. NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. (PMID: 22916032) Freed EF … Baserga SJ (PLoS genetics 2012) 3 4 58
  4. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. (PMID: 17699751) Prieto JL … McStay B (Genes & development 2007) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for UTP15 Gene

Sources for UTP15 Gene

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