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Aliases for PRAM1 Gene

Aliases for PRAM1 Gene

  • PML-RARA Regulated Adaptor Molecule 1 2 3 5
  • PRAM-1 3 4
  • PRAM 3 4
  • PML-RARA Target Gene Encoding An Adaptor Molecule-1 3
  • PML-RARA-Regulated Adapter Molecule 1 3
  • PML-RAR 3

External Ids for PRAM1 Gene

Previous GeneCards Identifiers for PRAM1 Gene

  • GC19M008461
  • GC19M008210
  • GC19M008554

Summaries for PRAM1 Gene

Entrez Gene Summary for PRAM1 Gene

  • The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]

GeneCards Summary for PRAM1 Gene

PRAM1 (PML-RARA Regulated Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with PRAM1 include Acute Promyelocytic Leukemia and Leukemia, Acute Myeloid. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is FYB1.

UniProtKB/Swiss-Prot for PRAM1 Gene

  • May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.

Gene Wiki entry for PRAM1 Gene

Additional gene information for PRAM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAM1 Gene

Genomics for PRAM1 Gene

GeneHancer (GH) Regulatory Elements for PRAM1 Gene

Promoters and enhancers for PRAM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008501 Promoter/Enhancer 1.4 EPDnew FANTOM5 ENCODE dbSUPER 664.3 +0.3 284 2 POLR2A HMBOX1 REST NR2C2 PRAM1 GC19P008503 MYO1F ZNF414 MARCH2 GC19P008487
GH19J008504 Enhancer 0.9 ENCODE dbSUPER 650.7 -1.4 -1423 0.7 HDAC1 TEAD4 MAX CTBP1 POLR2A VEZF1 CBFA2T2 RUNX3 CREM SMARCE1 GC19P008503 PRAM1 ZNF414
GH19J008511 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 -13.0 -12954 8.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF414 XAB2 ZNF317 MYO1F ZNF177 ZNF266 PRAM1 HNRNPM MAP2K7 ENSG00000267273
GH19J008574 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 10.7 -73.4 -73351 3.4 CTCF HDAC1 PKNOX1 MAX BACH1 BATF E4F1 CTBP1 ZNF316 ZNF366 MYO1F GC19M008577 PRAM1 ENSG00000267986 MARCH2 PIR49089
GH19J008444 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 9.3 +56.9 56942 3.9 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000279827 HNRNPM MARCH2 LINC01862 ENSG00000261866 OR7G3 LYPLA2P2 ELOCP29 OR7E25P OR7H1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRAM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRAM1 gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • Max
  • c-Myc
  • FOXC1
  • E47
  • Tal-1
  • AREB6
  • RORalpha1

Genomic Locations for PRAM1 Gene

Genomic Locations for PRAM1 Gene
chr19:8,490,055-8,503,112
(GRCh38/hg38)
Size:
13,058 bases
Orientation:
Minus strand
chr19:8,554,940-8,567,996
(GRCh37/hg19)
Size:
13,057 bases
Orientation:
Minus strand

Genomic View for PRAM1 Gene

Genes around PRAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAM1 Gene

Proteins for PRAM1 Gene

  • Protein details for PRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QH2-PRAM_HUMAN
    Recommended name:
    PML-RARA-regulated adapter molecule 1
    Protein Accession:
    Q96QH2
    Secondary Accessions:
    • Q8N6W7

    Protein attributes for PRAM1 Gene

    Size:
    670 amino acids
    Molecular mass:
    73969 Da
    Quaternary structure:
    • Interacts with SKAP2, LCP2 and DBNL. May interact with LYN. Interacts with NEK6.

neXtProt entry for PRAM1 Gene

Post-translational modifications for PRAM1 Gene

Other Protein References for PRAM1 Gene

No data available for DME Specific Peptides for PRAM1 Gene

Domains & Families for PRAM1 Gene

Gene Families for PRAM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRAM1 Gene

Suggested Antigen Peptide Sequences for PRAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QH2

UniProtKB/Swiss-Prot:

PRAM_HUMAN :
  • The SH3 domain binds to PtdIns(4)P.
Domain:
  • The SH3 domain binds to PtdIns(4)P.
genes like me logo Genes that share domains with PRAM1: view

Function for PRAM1 Gene

Molecular function for PRAM1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
UniProtKB/Swiss-Prot Induction:
Down-regulated by the PML-RARA oncogene, a fusion protein expressed in a vast majority of acute promyelocytic leukemia. Up-regulated by retinoic acid or arsenic trioxide in cells expressing PML-RARA.

Phenotypes From GWAS Catalog for PRAM1 Gene

Gene Ontology (GO) - Molecular Function for PRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0008289 lipid binding IEA --
GO:0019901 protein kinase binding IPI 20873783
genes like me logo Genes that share ontologies with PRAM1: view
genes like me logo Genes that share phenotypes with PRAM1: view

Animal Models for PRAM1 Gene

MGI Knock Outs for PRAM1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRAM1 Gene

Localization for PRAM1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAM1 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0032991 protein-containing complex IDA 20873783
genes like me logo Genes that share ontologies with PRAM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRAM1 Gene

Pathways & Interactions for PRAM1 Gene

SuperPathways for PRAM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
genes like me logo Genes that share ontologies with PRAM1: view

No data available for Pathways by source and SIGNOR curated interactions for PRAM1 Gene

Drugs & Compounds for PRAM1 Gene

No Compound Related Data Available

Transcripts for PRAM1 Gene

mRNA/cDNA for PRAM1 Gene

Unigene Clusters for PRAM1 Gene

PML-RARA regulated adaptor molecule 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAM1

Alternative Splicing Database (ASD) splice patterns (SP) for PRAM1 Gene

No ASD Table

Relevant External Links for PRAM1 Gene

GeneLoc Exon Structure for
PRAM1
ECgene alternative splicing isoforms for
PRAM1

Expression for PRAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRAM1 Gene

This gene is overexpressed in Whole Blood (x29.6).

Protein differential expression in normal tissues from HIPED for PRAM1 Gene

This gene is overexpressed in Monocytes (40.7) and Peripheral blood mononuclear cells (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRAM1 Gene



Protein tissue co-expression partners for PRAM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRAM1 Gene:

PRAM1

SOURCE GeneReport for Unigene cluster for PRAM1 Gene:

Hs.465812

mRNA Expression by UniProt/SwissProt for PRAM1 Gene:

Q96QH2-PRAM_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung.

Evidence on tissue expression from TISSUES for PRAM1 Gene

  • Blood(4.6)
  • Bone marrow(3.2)
genes like me logo Genes that share expression patterns with PRAM1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAM1 Gene

Orthologs for PRAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRAM1 34 33
  • 99.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRAM1 34 33
  • 78.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRAM1 34 33
  • 74.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pram1 16 34 33
  • 72.35 (n)
rat
(Rattus norvegicus)
Mammalia Pram1 33
  • 67.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU855733.1 34
  • 29 (a)
OneToOne
Species where no ortholog for PRAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRAM1 Gene

ENSEMBL:
Gene Tree for PRAM1 (if available)
TreeFam:
Gene Tree for PRAM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRAM1: view image

Paralogs for PRAM1 Gene

Paralogs for PRAM1 Gene

(1) SIMAP similar genes for PRAM1 Gene using alignment to 3 proteins:

  • PRAM_HUMAN
  • K4DI84_HUMAN
  • M0R149_HUMAN
genes like me logo Genes that share paralogs with PRAM1: view

Variants for PRAM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRAM1 Gene

PRAM_HUMAN-Q96QH2
Some transcripts displayed additional 12 amino acid repeats of K-P-P-[PQ]-P-[EQ]-[VAF]-T-D-L-P-K (PubMed:11301322). We cannot rule out that they may represent genetic variants.

Sequence variations from dbSNP and Humsavar for PRAM1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000149801 -- 8,503,806(-) G/T upstream_transcript_variant
rs1000176724 -- 8,496,184(-) GG/G intron_variant
rs1000438058 -- 8,504,118(-) G/A upstream_transcript_variant
rs1000593054 -- 8,499,499(-) G/A coding_sequence_variant, synonymous_variant
rs1000799892 -- 8,494,273(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRAM1 Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
nsv137944 CNV insertion 16902084
nsv458350 CNV loss 19166990
nsv578559 CNV loss 21841781

Variation tolerance for PRAM1 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAM1

SNP Genotyping and Copy Number Assay Products

Disorders for PRAM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRAM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute promyelocytic leukemia
  • apl
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search PRAM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRAM1

genes like me logo Genes that share disorders with PRAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAM1 Gene

Publications for PRAM1 Gene

  1. PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. (PMID: 11301322) Moog-Lutz C … Koretzky G (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G … Kobarg J (Journal of proteome research 2010) 3 4 58
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58
  4. Lipid-binding hSH3 domains in immune cell adapter proteins. (PMID: 16831444) Heuer K … Freund C (Journal of molecular biology 2006) 3 4 58
  5. PRAM-1 potentiates arsenic trioxide-induced JNK activation. (PMID: 15637062) Denis FM … Lutz PG (The Journal of biological chemistry 2005) 3 4 58

Products for PRAM1 Gene

Sources for PRAM1 Gene

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