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Aliases for NRIP2 Gene

Aliases for NRIP2 Gene

  • Nuclear Receptor Interacting Protein 2 2 3 5
  • Nuclear Receptor-Interacting Protein 2 3

External Ids for NRIP2 Gene

Previous GeneCards Identifiers for NRIP2 Gene

  • GC12M002813
  • GC12M002935

Summaries for NRIP2 Gene

GeneCards Summary for NRIP2 Gene

NRIP2 (Nuclear Receptor Interacting Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is NRIP3.

UniProtKB/Swiss-Prot for NRIP2 Gene

  • Down-regulates transcriptional activation by nuclear receptors such as NR1F2.

Gene Wiki entry for NRIP2 Gene

Additional gene information for NRIP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRIP2 Gene

Genomics for NRIP2 Gene

GeneHancer (GH) Regulatory Elements for NRIP2 Gene

Promoters and enhancers for NRIP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J002833 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 650.7 +0.8 792 1.7 CTCF ZSCAN4 KLF17 ZIC2 ZFHX2 GLIS2 EGR1 PATZ1 GLIS1 EGR2 NRIP2 LINC00940 ITFG2 ENSG00000256150
GH12J002889 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 11.9 -56.1 -56122 4.2 HDGF PKNOX1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF207 TULP3 RHNO1 NRIP2 ITFG2 DCP1B PIR60635 GC12M002940
GH12J002876 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 -42.1 -42129 3.3 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 ZNF143 TULP3 RHNO1 FOXM1 ITFG2 DCP1B CBX3P4 NRIP2 RPS27P3 FKBP4 GC12M002869
GH12J002784 Enhancer 1.1 FANTOM5 Ensembl ENCODE 17.7 +51.4 51408 0.3 CTCF RB1 SIN3A ZIC2 ZNF2 RAD21 SMC3 ZNF143 ZNF600 CHD2 NRIP2 ITFG2 RPL23AP14 GC12M002790 ENSG00000256150
GH12J002811 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.5 +22.4 22407 3 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ITFG2 ENSG00000256150 DCP1B TULP3 CACNA1C-AS3 ENSG00000256691 RPS26P44 CACNA1C-IT3 NRIP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRIP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRIP2 gene promoter:
  • GATA-2
  • HTF
  • AP-1
  • NF-1
  • NF-1/L
  • HFH-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1

Genomic Locations for NRIP2 Gene

Genomic Locations for NRIP2 Gene
10,663 bases
Minus strand
10,197 bases
Minus strand

Genomic View for NRIP2 Gene

Genes around NRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRIP2 Gene

Proteins for NRIP2 Gene

  • Protein details for NRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear receptor-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • A2RRE3
    • B4DV61

    Protein attributes for NRIP2 Gene

    281 amino acids
    Molecular mass:
    31331 Da
    Quaternary structure:
    • Interacts with NR1F2, RARA and THRB in a ligand-dependent manner.

    Alternative splice isoforms for NRIP2 Gene


neXtProt entry for NRIP2 Gene

Post-translational modifications for NRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRIP2 Gene

No data available for DME Specific Peptides for NRIP2 Gene

Domains & Families for NRIP2 Gene

Gene Families for NRIP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NRIP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRIP2: view

No data available for UniProtKB/Swiss-Prot for NRIP2 Gene

Function for NRIP2 Gene

Molecular function for NRIP2 Gene

UniProtKB/Swiss-Prot Function:
Down-regulates transcriptional activation by nuclear receptors such as NR1F2.

Phenotypes From GWAS Catalog for NRIP2 Gene

Gene Ontology (GO) - Molecular Function for NRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRIP2: view
genes like me logo Genes that share phenotypes with NRIP2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRIP2 Gene

Localization for NRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRIP2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRIP2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NRIP2: view

Pathways & Interactions for NRIP2 Gene

SuperPathways for NRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with NRIP2: view

No data available for Pathways by source and SIGNOR curated interactions for NRIP2 Gene

Drugs & Compounds for NRIP2 Gene

No Compound Related Data Available

Transcripts for NRIP2 Gene

mRNA/cDNA for NRIP2 Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NRIP2 Gene

Nuclear receptor interacting protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRIP2 Gene

No ASD Table

Relevant External Links for NRIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRIP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.1), Brain - Cerebellum (x6.6), and Nerve - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for NRIP2 Gene

This gene is overexpressed in Stomach (15.8), Heart (14.5), Uterus (12.4), and Gallbladder (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NRIP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NRIP2 Gene:


SOURCE GeneReport for Unigene cluster for NRIP2 Gene:


Evidence on tissue expression from TISSUES for NRIP2 Gene

  • Nervous system(4.6)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with NRIP2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRIP2 Gene

Orthologs for NRIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NRIP2 34 33
  • 99.53 (n)
(Canis familiaris)
Mammalia NRIP2 34 33
  • 87.7 (n)
(Mus musculus)
Mammalia Nrip2 16 34 33
  • 86.03 (n)
(Rattus norvegicus)
Mammalia Nrip2 33
  • 85.3 (n)
(Bos Taurus)
Mammalia NRIP2 34 33
  • 80.78 (n)
(Monodelphis domestica)
Mammalia NRIP2 34
  • 62 (a)
(Danio rerio)
Actinopterygii nrip2 34 33
  • 61.2 (n)
Species where no ortholog for NRIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRIP2 Gene

Gene Tree for NRIP2 (if available)
Gene Tree for NRIP2 (if available)
Evolutionary constrained regions (ECRs) for NRIP2: view image

Paralogs for NRIP2 Gene

Paralogs for NRIP2 Gene

(1) SIMAP similar genes for NRIP2 Gene using alignment to 4 proteins:

  • F5H065_HUMAN
  • F5H2G5_HUMAN
genes like me logo Genes that share paralogs with NRIP2: view

Variants for NRIP2 Gene

Sequence variations from dbSNP and Humsavar for NRIP2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000043980 -- 2,829,941(-) G/A intron_variant
rs1000330666 -- 2,830,958(-) C/G intron_variant
rs1000642943 -- 2,828,802(-) A/G intron_variant
rs1001730519 -- 2,835,659(-) AAAAAA/AAAAAAA upstream_transcript_variant
rs1001824460 -- 2,828,147(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NRIP2 Gene

Variant ID Type Subtype PubMed ID
dgv19n68 CNV loss 17160897
esv3628321 CNV gain 21293372
esv3628322 CNV gain 21293372
nsv832311 CNV loss 17160897

Variation tolerance for NRIP2 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRIP2 Gene

Disorders for NRIP2 Gene

Additional Disease Information for NRIP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NRIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRIP2 Gene

Publications for NRIP2 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Association of the RIP2 gene with childhood atopic asthma. (PMID: 17075290) Nakashima K … Tamari M (Allergology international : official journal of the Japanese Society of Allergology 2006) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ. (PMID: 28137278) Wen Z … Zhu Y (Molecular cancer 2017) 3 58

Products for NRIP2 Gene

Sources for NRIP2 Gene

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