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Aliases for SOX7 Gene

Aliases for SOX7 Gene

  • SRY-Box 7 2 3 5
  • SRY (Sex Determining Region Y)-Box 7 2 3
  • Transcription Factor SOX-7 3
  • SRY Box 7 2

External Ids for SOX7 Gene

Previous GeneCards Identifiers for SOX7 Gene

  • GC08M010645
  • GC08M010453
  • GC08M010618
  • GC08M009511
  • GC08M010581

Summaries for SOX7 Gene

Entrez Gene Summary for SOX7 Gene

  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX7 Gene

SOX7 (SRY-Box 7) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ENSG00000258724.

UniProtKB/Swiss-Prot for SOX7 Gene

  • Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3.

Additional gene information for SOX7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX7 Gene

Genomics for SOX7 Gene

GeneHancer (GH) Regulatory Elements for SOX7 Gene

Promoters and enhancers for SOX7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J010728 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 726 2.6 RAD21 ZNF335 GLIS2 ZNF143 ZNF398 ZEB2 SP1 ZNF610 KLF16 GLIS1 GC08M010730 LOC102723313 SOX7 C8orf74 RP1L1 ENSG00000269918 ENSG00000258724
GH08J010775 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -46.7 -46669 3.3 PKNOX1 SMAD1 ARNT ZNF766 CBX5 REST ZNF592 SMARCA4 NBN HMBOX1 PINX1 LOC101929290 RP1L1 SOX7 ENSG00000255310 ENSG00000269918 GC08M010757 GC08M010803 LOC102723313 ENSG00000258724
GH08J010798 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -69.9 -69872 4 PKNOX1 ATF1 ARNT ARID4B FEZF1 ETS1 YY1 TCF12 ATF7 FOS RP1L1 C8orf74 LOC102723313 ENSG00000269918 SOX7 ENSG00000255310 GC08M010803 ENSG00000258724 GC08M010757 PINX1
GH08J010787 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 8.7 -58.5 -58497 3.1 CTCF JUN TAL1 STAT5A BATF RAD21 CTBP1 MTA3 EED ZNF143 ENSG00000255310 SOX7 RP1L1 ENSG00000269918 GC08M010803 GC08M010757 ENSG00000258724 PINX1
GH08J010812 Enhancer 0.8 ENCODE dbSUPER 17.1 -83.3 -83329 2.1 CTCF ZNF197 REST ELF1 RAD21 GABPA ZNF395 ZNF148 FOSL1 IKZF1 SOX7 RP1L1 LOC101929229 PINX1 ENSG00000269918 GC08M010803 MIR1322 ENSG00000258724
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOX7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SOX7 gene promoter:
  • FOXJ2 (long isoform)
  • FOXJ2
  • FOXL1
  • RFX1
  • AREB6
  • RP58
  • FAC1
  • Msx-1
  • MyoD
  • Lmo2

Genomic Locations for SOX7 Gene

Genomic Locations for SOX7 Gene
chr8:10,723,768-10,730,574
(GRCh38/hg38)
Size:
6,807 bases
Orientation:
Minus strand
chr8:10,581,278-10,697,357
(GRCh37/hg19)
Size:
116,080 bases
Orientation:
Minus strand

Genomic View for SOX7 Gene

Genes around SOX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX7 Gene

Proteins for SOX7 Gene

  • Protein details for SOX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT81-SOX7_HUMAN
    Recommended name:
    Transcription factor SOX-7
    Protein Accession:
    Q9BT81
    Secondary Accessions:
    • B4DKV0
    • Q53YD0

    Protein attributes for SOX7 Gene

    Size:
    388 amino acids
    Molecular mass:
    42197 Da
    Quaternary structure:
    • Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.

    Alternative splice isoforms for SOX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOX7 Gene

Post-translational modifications for SOX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX7 Gene

Domains & Families for SOX7 Gene

Gene Families for SOX7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SOX7 Gene

Suggested Antigen Peptide Sequences for SOX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SOX7: view

No data available for UniProtKB/Swiss-Prot for SOX7 Gene

Function for SOX7 Gene

Molecular function for SOX7 Gene

UniProtKB/Swiss-Prot Function:
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3.

Phenotypes From GWAS Catalog for SOX7 Gene

Gene Ontology (GO) - Molecular Function for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA,IDA 19108950
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SOX7: view
genes like me logo Genes that share phenotypes with SOX7: view

Animal Models for SOX7 Gene

MGI Knock Outs for SOX7:
  • Sox7 Sox7<tm1.1Dsco>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX7 Gene

Localization for SOX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX7 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOX7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18682240
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 18819930
genes like me logo Genes that share ontologies with SOX7: view

Pathways & Interactions for SOX7 Gene

genes like me logo Genes that share pathways with SOX7: view

Interacting Proteins for SOX7 Gene

Gene Ontology (GO) - Biological Process for SOX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001706 endoderm formation IDA 18682240
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008285 negative regulation of cell proliferation IDA 19108950
genes like me logo Genes that share ontologies with SOX7: view

No data available for SIGNOR curated interactions for SOX7 Gene

Drugs & Compounds for SOX7 Gene

No Compound Related Data Available

Transcripts for SOX7 Gene

mRNA/cDNA for SOX7 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX7 Gene

SRY (sex determining region Y)-box 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOX7 Gene

No ASD Table

Relevant External Links for SOX7 Gene

GeneLoc Exon Structure for
SOX7
ECgene alternative splicing isoforms for
SOX7

Expression for SOX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX7 Gene

This gene is overexpressed in Vagina (x8.0) and Cervix - Ectocervix (x6.9).

NURSA nuclear receptor signaling pathways regulating expression of SOX7 Gene:

SOX7

SOURCE GeneReport for Unigene cluster for SOX7 Gene:

Hs.709543

mRNA Expression by UniProt/SwissProt for SOX7 Gene:

Q9BT81-SOX7_HUMAN
Tissue specificity: Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.

Evidence on tissue expression from TISSUES for SOX7 Gene

  • Lung(4.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with SOX7: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOX7 Gene

Orthologs for SOX7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOX7 33
  • 93.33 (n)
dog
(Canis familiaris)
Mammalia SOX7 33
  • 91.26 (n)
cow
(Bos Taurus)
Mammalia SOX7 33
  • 87.82 (n)
mouse
(Mus musculus)
Mammalia Sox7 16 34 33
  • 85.44 (n)
rat
(Rattus norvegicus)
Mammalia Sox7 33
  • 84.77 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves SOX7 33
  • 72.83 (n)
-- 34
  • 61 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sox7 33
  • 67.41 (n)
Str.1804 33
African clawed frog
(Xenopus laevis)
Amphibia sox7-A 33
zebrafish
(Danio rerio)
Actinopterygii sox7 34 33 33
  • 65.1 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sox15 34 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
OneToMany
Species where no ortholog for SOX7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOX7 Gene

ENSEMBL:
Gene Tree for SOX7 (if available)
TreeFam:
Gene Tree for SOX7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SOX7: view image

Paralogs for SOX7 Gene

(9) SIMAP similar genes for SOX7 Gene using alignment to 2 proteins:

  • SOX7_HUMAN
  • B4DKV0_HUMAN
genes like me logo Genes that share paralogs with SOX7: view

Variants for SOX7 Gene

Sequence variations from dbSNP and Humsavar for SOX7 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs879255423 uncertain-significance, not specified 10,726,113(-) C/G coding_sequence_variant, missense_variant
rs1000177021 -- 10,730,449(-) G/A 5_prime_UTR_variant
rs1000250441 -- 10,730,558(-) C/T 5_prime_UTR_variant
rs1000259362 -- 10,725,414(-) C/T 3_prime_UTR_variant
rs1000636595 -- 10,724,605(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SOX7 Gene

Variant ID Type Subtype PubMed ID
nsv1032725 CNV loss 25217958
nsv527184 CNV loss 19592680

Variation tolerance for SOX7 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOX7 Gene

Human Gene Mutation Database (HGMD)
SOX7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOX7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX7 Gene

Disorders for SOX7 Gene

Additional Disease Information for SOX7

No disorders were found for SOX7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOX7 Gene

Publications for SOX7 Gene

  1. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. (PMID: 11691915) Takash W … Berta P (Nucleic acids research 2001) 2 3 4 22 58
  2. Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. (PMID: 18819930) Guo L … Zhou W (Molecular cancer research : MCR 2008) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. SOX7 Suppresses Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction. (PMID: 29271667) Fan R … Fan M (DNA and cell biology 2018) 3 58

Products for SOX7 Gene

Sources for SOX7 Gene

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