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Aliases for THAP2 Gene

Aliases for THAP2 Gene

  • THAP Domain Containing 2 2 3 5
  • THAP Domain Containing, Apoptosis Associated Protein 2 2 3
  • THAP Domain-Containing Protein 2 3

External Ids for THAP2 Gene

Previous GeneCards Identifiers for THAP2 Gene

  • GC00U909479
  • GC12P070345
  • GC12P072057
  • GC12P069106

Summaries for THAP2 Gene

GeneCards Summary for THAP2 Gene

THAP2 (THAP Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP1.

Gene Wiki entry for THAP2 Gene

Additional gene information for THAP2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP2 Gene

Genomics for THAP2 Gene

GeneHancer (GH) Regulatory Elements for THAP2 Gene

Promoters and enhancers for THAP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J071661 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 843 4.8 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 THAP2 ZFC3H1 TMEM19 ENSG00000257515
GH12J071625 Enhancer 1.1 ENCODE dbSUPER 11.2 -36.1 -36089 1.9 HDAC1 INSM2 FEZF1 ZNF335 TCF12 ZNF213 ZNF366 ZSCAN5C ATF7 IKZF2 ZFC3H1 THAP2 ENSG00000257515 GC12P071640 ENSG00000257761
GH12J071753 Enhancer 0.9 FANTOM5 11.2 +90.1 90123 0.1 HDAC1 ATF1 ARNT CHAMP1 NCOA2 TCF12 ZNF766 GATA2 CREM CEBPB RAB21 TMEM19 ZFC3H1 THAP2 ENSG00000212461 ENSG00000257515
GH12J071638 Enhancer 0.6 dbSUPER 12.1 -23.5 -23472 2.2 CTCF MAFG REST RAD21 MAFF ZNF316 SMC3 MAFK EMSY GC12P071640 ENSG00000212461 ZFC3H1 THAP2 ENSG00000257515 LGR5
GH12J071747 Enhancer 0.6 ENCODE 11.1 +84.2 84167 0.2 CTCF ZNF654 TRIM22 CEBPB REST CEBPG RAD21 CC2D1A ZNF335 ARID2 TMEM19 ZFC3H1 THAP2 ENSG00000212461 RAB21 ENSG00000257515
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around THAP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THAP2 gene promoter:
  • GATA-1
  • Nkx2-5
  • PPAR-alpha
  • POU2F1a
  • POU2F1
  • AML1a
  • TFIID
  • TBP
  • Pax-4a

Genomic Locations for THAP2 Gene

Genomic Locations for THAP2 Gene
chr12:71,663,009-71,680,648
(GRCh38/hg38)
Size:
17,640 bases
Orientation:
Plus strand
chr12:72,056,789-72,074,428
(GRCh37/hg19)
Size:
17,640 bases
Orientation:
Plus strand

Genomic View for THAP2 Gene

Genes around THAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP2 Gene

Proteins for THAP2 Gene

  • Protein details for THAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0W7-THAP2_HUMAN
    Recommended name:
    THAP domain-containing protein 2
    Protein Accession:
    Q9H0W7
    Secondary Accessions:
    • B2R8P3

    Protein attributes for THAP2 Gene

    Size:
    228 amino acids
    Molecular mass:
    26260 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for THAP2 Gene

neXtProt entry for THAP2 Gene

Post-translational modifications for THAP2 Gene

  • Ubiquitination at posLast=143143
  • Modification sites at PhosphoSitePlus

Other Protein References for THAP2 Gene

No data available for DME Specific Peptides for THAP2 Gene

Domains & Families for THAP2 Gene

Gene Families for THAP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THAP2: view

No data available for UniProtKB/Swiss-Prot for THAP2 Gene

Function for THAP2 Gene

Phenotypes From GWAS Catalog for THAP2 Gene

Gene Ontology (GO) - Molecular Function for THAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP2: view
genes like me logo Genes that share phenotypes with THAP2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP2 Gene

Localization for THAP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
golgi apparatus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with THAP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THAP2 Gene

Pathways & Interactions for THAP2 Gene

SuperPathways for THAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with THAP2: view

No data available for Pathways by source and SIGNOR curated interactions for THAP2 Gene

Drugs & Compounds for THAP2 Gene

No Compound Related Data Available

Transcripts for THAP2 Gene

mRNA/cDNA for THAP2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(222) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THAP2 Gene

THAP domain containing, apoptosis associated protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP2 Gene

No ASD Table

Relevant External Links for THAP2 Gene

GeneLoc Exon Structure for
THAP2
ECgene alternative splicing isoforms for
THAP2

Expression for THAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THAP2 Gene

Protein differential expression in normal tissues from HIPED for THAP2 Gene

This gene is overexpressed in Colon muscle (30.9) and Esophagus (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THAP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of THAP2 Gene:

THAP2

SOURCE GeneReport for Unigene cluster for THAP2 Gene:

Hs.245798

Evidence on tissue expression from TISSUES for THAP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with THAP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP2 Gene

Orthologs for THAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP2 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia THAP2 34 33
  • 93.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia THAP2 34 33
  • 92.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Thap2 16 34 33
  • 90.97 (n)
rat
(Rattus norvegicus)
Mammalia Thap2 33
  • 88.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia thap2 33
  • 54.26 (n)
Species where no ortholog for THAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THAP2 Gene

ENSEMBL:
Gene Tree for THAP2 (if available)
TreeFam:
Gene Tree for THAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for THAP2: view image

Paralogs for THAP2 Gene

Paralogs for THAP2 Gene

(2) SIMAP similar genes for THAP2 Gene using alignment to 4 proteins:

  • THAP2_HUMAN
  • F8VW94_HUMAN
  • F8VYP5_HUMAN
  • F8W1B8_HUMAN
genes like me logo Genes that share paralogs with THAP2: view

Variants for THAP2 Gene

Sequence variations from dbSNP and Humsavar for THAP2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000008631 -- 71,667,745(+) G/T intron_variant
rs1000239142 -- 71,675,263(+) T/C/G intron_variant
rs1000490914 -- 71,668,071(+) C/T intron_variant
rs1000879646 -- 71,668,059(+) C/T intron_variant
rs1001014850 -- 71,667,758(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THAP2 Gene

Variant ID Type Subtype PubMed ID
nsv832451 CNV loss 17160897

Variation tolerance for THAP2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP2 Gene

Disorders for THAP2 Gene

Additional Disease Information for THAP2

No disorders were found for THAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP2 Gene

Publications for THAP2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for THAP2 Gene

Sources for THAP2 Gene

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