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Aliases for SH3BGRL3 Gene

Aliases for SH3BGRL3 Gene

  • SH3 Domain Binding Glutamate Rich Protein Like 3 2 3 5
  • SH3 Domain Binding Glutamic Acid-Rich Protein Like 3 2 3
  • SH3 Domain-Binding Protein 1 3 4
  • SH3BP-1 3 4
  • SH3 Domain-Binding Glutamic Acid-Rich-Like Protein 3 3
  • Epididymis Secretory Protein Li 297 3
  • TNF Inhibitory Protein 3
  • SH3BGRL3-Like Protein 3
  • HEL-S-297 3
  • TIP-B1 3

External Ids for SH3BGRL3 Gene

Previous GeneCards Identifiers for SH3BGRL3 Gene

  • GC01P026086
  • GC01P025627
  • GC01P025838
  • GC01P026211
  • GC01P026478
  • GC01P026605
  • GC01P024860

Summaries for SH3BGRL3 Gene

GeneCards Summary for SH3BGRL3 Gene

SH3BGRL3 (SH3 Domain Binding Glutamate Rich Protein Like 3) is a Protein Coding gene. Diseases associated with SH3BGRL3 include Brain Cancer. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and protein disulfide oxidoreductase activity. An important paralog of this gene is SH3BGRL2.

UniProtKB/Swiss-Prot for SH3BGRL3 Gene

  • Could act as a modulator of glutaredoxin biological activity.

Gene Wiki entry for SH3BGRL3 Gene

Additional gene information for SH3BGRL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGRL3 Gene

Genomics for SH3BGRL3 Gene

GeneHancer (GH) Regulatory Elements for SH3BGRL3 Gene

Promoters and enhancers for SH3BGRL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J026274 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 653.2 +4.7 4718 19.1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NBN SH3BGRL3 HMGN2 ARID1A LOC101928324 CD52 GPN2 NPM1P39 UBXN11 CEP85 LIN28A
GH01J026313 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 17.5 +39.0 38994 8.4 HDGF PKNOX1 SMAD1 ARNT ARID4B ZNF2 IRF4 ZNF766 ZNF213 E2F8 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ZNF593 ENSG00000236782 FAM110D
GH01J026110 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -166.8 -166793 4.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 PDIK1L GPN2 ARID1A TRIM63 LOC101928324 GPATCH3 ENSG00000261349 HMGN2 LOC101928728 SH3BGRL3
GH01J025817 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 -459.1 -459145 4.7 HDGF HNRNPUL1 PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 MTFR1L SELENON ARID1A HMGN2 LOC101928324 ENSG00000261349 SYF2 PIGV SH3BGRL3 LOC101928728
GH01J026618 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 +341.2 341220 4 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 ARID1A HMGN2 ACTG1P20 GPN2 LOC101928324 GPATCH3 AHDC1 RPL17P9 NPM1P39 ZNF593
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SH3BGRL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH3BGRL3 gene promoter:
  • Lmo2
  • GATA-1
  • ZID
  • YY1
  • CREB
  • deltaCREB
  • AML1a
  • FOXO3
  • FOXO3a
  • FOXO3b

Genomic Locations for SH3BGRL3 Gene

Genomic Locations for SH3BGRL3 Gene
2,347 bases
Plus strand
2,347 bases
Plus strand

Genomic View for SH3BGRL3 Gene

Genes around SH3BGRL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BGRL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BGRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGRL3 Gene

Proteins for SH3BGRL3 Gene

  • Protein details for SH3BGRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding glutamic acid-rich-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5T122

    Protein attributes for SH3BGRL3 Gene

    93 amino acids
    Molecular mass:
    10438 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SH3BGRL3 Gene

neXtProt entry for SH3BGRL3 Gene

Post-translational modifications for SH3BGRL3 Gene

  • Ubiquitination at isoforms=18
  • Modification sites at PhosphoSitePlus

Other Protein References for SH3BGRL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH3BGRL3 Gene

Domains & Families for SH3BGRL3 Gene

Gene Families for SH3BGRL3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SH3BGRL3 Gene

Suggested Antigen Peptide Sequences for SH3BGRL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SH3BGR family.
  • Belongs to the SH3BGR family.
genes like me logo Genes that share domains with SH3BGRL3: view

Function for SH3BGRL3 Gene

Molecular function for SH3BGRL3 Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of glutaredoxin biological activity.

Phenotypes From GWAS Catalog for SH3BGRL3 Gene

Gene Ontology (GO) - Molecular Function for SH3BGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009055 electron transfer activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with SH3BGRL3: view
genes like me logo Genes that share phenotypes with SH3BGRL3: view

Animal Models for SH3BGRL3 Gene

MGI Knock Outs for SH3BGRL3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH3BGRL3 Gene

Localization for SH3BGRL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3BGRL3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3BGRL3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SH3BGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016604 nuclear body IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with SH3BGRL3: view

Pathways & Interactions for SH3BGRL3 Gene

SuperPathways for SH3BGRL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3BGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022900 electron transport chain IEA --
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SH3BGRL3: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BGRL3 Gene

Drugs & Compounds for SH3BGRL3 Gene

No Compound Related Data Available

Transcripts for SH3BGRL3 Gene

mRNA/cDNA for SH3BGRL3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(610) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH3BGRL3 Gene

SH3 domain binding glutamic acid-rich protein like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGRL3 Gene

No ASD Table

Relevant External Links for SH3BGRL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BGRL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3BGRL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BGRL3 Gene

This gene is overexpressed in Whole Blood (x14.1).

Protein differential expression in normal tissues from HIPED for SH3BGRL3 Gene

This gene is overexpressed in Platelet (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SH3BGRL3 Gene

Protein tissue co-expression partners for SH3BGRL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH3BGRL3 Gene:


SOURCE GeneReport for Unigene cluster for SH3BGRL3 Gene:


mRNA Expression by UniProt/SwissProt for SH3BGRL3 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SH3BGRL3 Gene

  • Lung(4.5)
  • Pancreas(4.4)
  • Skin(4.4)
  • Liver(4.3)
  • Nervous system(3.3)
  • Intestine(2.5)
  • Blood(2.4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SH3BGRL3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3BGRL3 Gene

Orthologs for SH3BGRL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGRL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3BGRL3 34 33
  • 99.28 (n)
(Canis familiaris)
Mammalia SH3BGRL3 34 33
  • 96.42 (n)
(Bos Taurus)
Mammalia SH3BGRL3 34 33
  • 96.06 (n)
(Mus musculus)
Mammalia Sh3bgrl3 16 34 33
  • 91.4 (n)
(Rattus norvegicus)
Mammalia Sh3bgrl3 33
  • 90.32 (n)
(Monodelphis domestica)
Mammalia SH3BGRL3 34
  • 90 (a)
(Gallus gallus)
Aves SH3BGRL3 34 33
  • 84.23 (n)
(Anolis carolinensis)
Reptilia SH3BGRL3 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bgrl3 33
  • 65.17 (n)
Str.20441 33
(Danio rerio)
Actinopterygii sh3bgrl3 34 33
  • 64.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 34
  • 8 (a)
(Caenorhabditis elegans)
Secernentea Y105E8A.1 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 13 (a)
Species where no ortholog for SH3BGRL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGRL3 Gene

Gene Tree for SH3BGRL3 (if available)
Gene Tree for SH3BGRL3 (if available)
Evolutionary constrained regions (ECRs) for SH3BGRL3: view image

Paralogs for SH3BGRL3 Gene

Paralogs for SH3BGRL3 Gene

(4) SIMAP similar genes for SH3BGRL3 Gene using alignment to 3 proteins:

  • Q5T123_HUMAN Pseudogenes for SH3BGRL3 Gene

genes like me logo Genes that share paralogs with SH3BGRL3: view

Variants for SH3BGRL3 Gene

Sequence variations from dbSNP and Humsavar for SH3BGRL3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000159614 -- 26,280,296(+) G/A intron_variant
rs1001179765 -- 26,280,488(+) G/T intron_variant
rs1001649479 -- 26,279,433(+) T/C upstream_transcript_variant
rs1001804078 -- 26,279,712(+) C/T upstream_transcript_variant
rs1002219626 -- 26,279,771(+) T/C 5_prime_UTR_variant

Variation tolerance for SH3BGRL3 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH3BGRL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SH3BGRL3 Gene

Disorders for SH3BGRL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SH3BGRL3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SH3BGRL3

genes like me logo Genes that share disorders with SH3BGRL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH3BGRL3 Gene

Publications for SH3BGRL3 Gene

  1. NMR structure and regulated expression in APL cell of human SH3BGRL3. (PMID: 15907482) Xu C … Shi Y (FEBS letters 2005) 3 4 22 58
  2. A novel human homologue of the SH3BGR gene encodes a small protein similar to Glutaredoxin 1 of Escherichia coli. (PMID: 11444877) Mazzocco M … Scartezzini P (Biochemical and biophysical research communications 2001) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations. (PMID: 28378594) Sala S … Ampe C (Journal of proteome research 2017) 3 58
  5. SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor. (PMID: 26286913) Chiang CY … Chow NH (Clinical cancer research : an official journal of the American Association for Cancer Research 2015) 3 58

Products for SH3BGRL3 Gene

Sources for SH3BGRL3 Gene

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