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Aliases for FCRL4 Gene

Aliases for FCRL4 Gene

  • Fc Receptor Like 4 2 3 5
  • Immune Receptor Translocation-Associated Protein 1 3 4
  • Fc Receptor Homolog 4 3 4
  • IFGP Family Protein 2 3 4
  • FcR-Like Protein 4 3 4
  • HIFGP2 3 4
  • FCRH4 3 4
  • IRTA1 3 4
  • Immunoglobulin Superfamily Receptor Translocation Associated 1 3
  • Immunoglobulin Superfamily Fc Receptor, Gp42 3
  • Fc Receptor-Like Protein 4 3
  • Fc Receptor-Like 4 2
  • CD307d Antigen 4
  • CD307d 3
  • IGFP2 3
  • FcRH4 4
  • FcRL4 4
  • IFGP2 4

External Ids for FCRL4 Gene

Previous GeneCards Identifiers for FCRL4 Gene

  • GC01M154357
  • GC01M155811
  • GC01M128901

Summaries for FCRL4 Gene

Entrez Gene Summary for FCRL4 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCRL4 Gene

FCRL4 (Fc Receptor Like 4) is a Protein Coding gene. Among its related pathways are Microglia Activation During Neuroinflammation: Steady-State Microglia. An important paralog of this gene is FCRL5.

UniProtKB/Swiss-Prot for FCRL4 Gene

  • May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.

Gene Wiki entry for FCRL4 Gene

Additional gene information for FCRL4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL4 Gene

Genomics for FCRL4 Gene

GeneHancer (GH) Regulatory Elements for FCRL4 Gene

Promoters and enhancers for FCRL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J157598 Promoter 0.9 EPDnew 650.7 0.0 -25 0.1 NR2F1 DPF2 ATF2 BCL11A IKZF1 NBN RUNX3 IKZF2 SPI1 FCRL4 ENSG00000236731
GH01J157595 Enhancer 0.8 ENCODE 0.7 +2.5 2544 0.1 BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM CBFB FCRL5 ENSG00000227217 FCRL3 FCRL2 FCRL1 FCRL4
GH01J157552 Promoter/Enhancer 1.2 EPDnew ENCODE 0.2 +45.5 45515 1 PKNOX1 SMAD1 IRF4 RELA POLR2A NFATC1 ATF7 BCLAF1 IKZF2 RUNX3 FCRL5 FCRL4 GC01P157412
GH01J157562 Enhancer 0.7 FANTOM5 0.3 +35.4 35405 0.3 SRF PKNOX1 MEF2B DPF2 ATF2 ZNF217 IKZF1 NFATC1 NBN ATF7 FCRL5 FCRL4
GH01J157566 Enhancer 0.6 ENCODE 0.3 +31.1 31124 1.7 MAFG MEF2B ELF1 RELA ZNF217 IKZF1 VEZF1 NFATC1 ATF7 NFE2 FCRL5 ENSG00000227217 FCRL3 FCRL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCRL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCRL4 gene promoter:
  • SEF-1 (1)
  • FOXO4
  • FOXO1
  • FOXO1a
  • NRSF form 1
  • NRSF form 2

Genomic Locations for FCRL4 Gene

Genomic Locations for FCRL4 Gene
24,332 bases
Minus strand
24,332 bases
Minus strand

Genomic View for FCRL4 Gene

Genes around FCRL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL4 Gene

Proteins for FCRL4 Gene

  • Protein details for FCRL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fc receptor-like protein 4
    Protein Accession:
    Secondary Accessions:
    • Q96PJ3
    • Q96RE0

    Protein attributes for FCRL4 Gene

    515 amino acids
    Molecular mass:
    57224 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCRL4 Gene


neXtProt entry for FCRL4 Gene

Post-translational modifications for FCRL4 Gene

Other Protein References for FCRL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FCRL4 Gene

Domains & Families for FCRL4 Gene

Gene Families for FCRL4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Predicted membrane proteins

Protein Domains for FCRL4 Gene

Suggested Antigen Peptide Sequences for FCRL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCRL4: view

No data available for UniProtKB/Swiss-Prot for FCRL4 Gene

Function for FCRL4 Gene

Molecular function for FCRL4 Gene

UniProtKB/Swiss-Prot Function:
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.

Gene Ontology (GO) - Molecular Function for FCRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with FCRL4: view
genes like me logo Genes that share phenotypes with FCRL4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCRL4 Gene

Localization for FCRL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRL4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FCRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 16849395
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with FCRL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCRL4 Gene

Pathways & Interactions for FCRL4 Gene

genes like me logo Genes that share pathways with FCRL4: view

Pathways by source for FCRL4 Gene

Gene Ontology (GO) - Biological Process for FCRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with FCRL4: view

No data available for SIGNOR curated interactions for FCRL4 Gene

Drugs & Compounds for FCRL4 Gene

No Compound Related Data Available

Transcripts for FCRL4 Gene

mRNA/cDNA for FCRL4 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCRL4 Gene

Fc receptor-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL4 Gene

No ASD Table

Relevant External Links for FCRL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCRL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRL4 Gene

mRNA differential expression in normal tissues according to GTEx for FCRL4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x14.2) and Spleen (x5.7).

Protein differential expression in normal tissues from HIPED for FCRL4 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL4 Gene

Protein tissue co-expression partners for FCRL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FCRL4 Gene:


SOURCE GeneReport for Unigene cluster for FCRL4 Gene:


mRNA Expression by UniProt/SwissProt for FCRL4 Gene:

Tissue specificity: Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).

Evidence on tissue expression from TISSUES for FCRL4 Gene

  • Lymph node(4.3)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with FCRL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL4 Gene

Orthologs for FCRL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FCRL4 34 33
  • 98.77 (n)
(Bos Taurus)
Mammalia FCRL4 33
  • 76.39 (n)
(Canis familiaris)
Mammalia FCRL4 34 33
  • 76.12 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
-- 34
  • 44 (a)
-- 34
  • 37 (a)
-- 34
  • 36 (a)
-- 34
  • 36 (a)
-- 34
  • 30 (a)
(Gallus gallus)
Aves FCRL2 34
  • 36 (a)
Species where no ortholog for FCRL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL4 Gene

Gene Tree for FCRL4 (if available)
Gene Tree for FCRL4 (if available)
Evolutionary constrained regions (ECRs) for FCRL4: view image

Paralogs for FCRL4 Gene

(4) SIMAP similar genes for FCRL4 Gene using alignment to 1 proteins:

  • FCRL4_HUMAN Pseudogenes for FCRL4 Gene

genes like me logo Genes that share paralogs with FCRL4: view

Variants for FCRL4 Gene

Sequence variations from dbSNP and Humsavar for FCRL4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000125837 -- 157,599,491(-) T/G upstream_transcript_variant
rs1000463315 -- 157,578,446(-) C/A intron_variant
rs1000655940 -- 157,594,124(-) A/C intron_variant
rs1000657728 -- 157,594,918(-) T/C intron_variant
rs1000743145 -- 157,588,698(-) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL4 Gene

Variant ID Type Subtype PubMed ID
esv2661330 CNV deletion 23128226
esv2718507 CNV deletion 23290073
esv3587653 CNV loss 21293372
nsv3154 CNV insertion 18451855

Variation tolerance for FCRL4 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCRL4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL4 Gene

Disorders for FCRL4 Gene


  • Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). {ECO:0000269 PubMed:12619161}.
  • Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. {ECO:0000269 PubMed:11290337}.

Additional Disease Information for FCRL4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FCRL4 Gene.

No data available for MalaCards and Genatlas for FCRL4 Gene

Publications for FCRL4 Gene

  1. Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). (PMID: 12881317) Falini B … Cattoretti G (Blood 2003) 3 4 22 58
  2. IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. (PMID: 11929751) Miller I … Dalla-Favera R (Blood 2002) 3 4 22 58
  3. Identification of a family of Fc receptor homologs with preferential B cell expression. (PMID: 11493702) Davis RS … Cooper MD (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 58
  4. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. (PMID: 11290337) Hatzivassiliou G … Dalla-Favera R (Immunity 2001) 2 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for FCRL4 Gene

Sources for FCRL4 Gene

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