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Aliases for CANX Gene

Aliases for CANX Gene

  • Calnexin 2 3 3 5
  • Major Histocompatibility Complex Class I Antigen-Binding Protein P88 2 3 4
  • IP90 3 4
  • P90 3 4
  • CNX 3

External Ids for CANX Gene

Previous GeneCards Identifiers for CANX Gene

  • GC05P179238
  • GC05P180070
  • GC05P179190
  • GC05P179235
  • GC05P179058
  • GC05P179105
  • GC05P173852

Summaries for CANX Gene

Entrez Gene Summary for CANX Gene

  • This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CANX Gene

CANX (Calnexin) is a Protein Coding gene. Diseases associated with CANX include Orbital Melanoma and Hyperhidrosis, Gustatory. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLGN.

UniProtKB/Swiss-Prot for CANX Gene

  • Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

Gene Wiki entry for CANX Gene

Additional gene information for CANX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CANX Gene

Genomics for CANX Gene

GeneHancer (GH) Regulatory Elements for CANX Gene

Promoters and enhancers for CANX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I179696 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 572.5 +20.3 20317 4.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC CANX GC05M179696 MAML1 HNRNPH1 ZNF354B RUFY1 MRNIP ZNF879 LOC101928445 ADAMTS2
GH05I179677 Promoter/Enhancer 1.6 Ensembl ENCODE 550.8 0.0 -22 2.3 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 HMGB3P22 CANX MRNIP HNRNPH1 MAML1 ZNF354B ZNF879 CNOT6 RUFY1 TBC1D9B
GH05I179758 Enhancer 1.2 Ensembl ENCODE dbSUPER 18 +81.2 81172 2 HDGF PKNOX1 BATF ZNF121 ZNF366 FOS RCOR1 RUNX3 EGR2 ZNF280D MAML1 CANX LTC4S MIR1229 SQSTM1 MGAT4B HMGB3P22 CBY3 TBC1D9B MRNIP
GH05I179817 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.2 +141.9 141931 6.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SQSTM1 MRNIP HNRNPH1 MAML1 ZNF354C TBC1D9B RUFY1 RNF130 LOC105377763 ZNF879
GH05I179803 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 7.9 +127.3 127315 5.9 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 SP5 MGAT4B SQSTM1 ZNF879 LOC100996419 ZFP2 ZNF454 GRM6 ENSG00000254035 ZNF354C MRNIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CANX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CANX gene promoter:

Genomic Locations for CANX Gene

Genomic Locations for CANX Gene
chr5:179,678,628-179,731,641
(GRCh38/hg38)
Size:
53,014 bases
Orientation:
Plus strand
chr5:179,105,629-179,158,642
(GRCh37/hg19)

Genomic View for CANX Gene

Genes around CANX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CANX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CANX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CANX Gene

Proteins for CANX Gene

  • Protein details for CANX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27824-CALX_HUMAN
    Recommended name:
    Calnexin
    Protein Accession:
    P27824
    Secondary Accessions:
    • B2R5V8
    • B4DGP8
    • B4E2T8
    • D3DWQ3
    • D6R9K3

    Protein attributes for CANX Gene

    Size:
    592 amino acids
    Molecular mass:
    67568 Da
    Quaternary structure:
    • Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (PubMed:16361248). Associates with ribosomes (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (PubMed:22314232). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (PubMed:23826168). Interacts with PPIB (PubMed:20801878). Interacts with ZNRF4 (PubMed:21205830).

    Alternative splice isoforms for CANX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CANX Gene

Post-translational modifications for CANX Gene

  • Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.
  • Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
  • Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.
  • Ubiquitination at posLast=103103, posLast=118118, posLast=137137, Lys170, posLast=182182, posLast=227227, Lys398, posLast=401401, and Lys515
  • Glycosylation at Thr59, Thr66, and Thr79
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CANX Gene

Domains & Families for CANX Gene

Gene Families for CANX Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CANX Gene

Graphical View of Domain Structure for InterPro Entry

P27824

UniProtKB/Swiss-Prot:

CALX_HUMAN :
  • Belongs to the calreticulin family.
Family:
  • Belongs to the calreticulin family.
genes like me logo Genes that share domains with CANX: view

Function for CANX Gene

Molecular function for CANX Gene

GENATLAS Biochemistry:
calnexin,90kDa,integral membrane,calcium binding protein,chaperone,interacting with an ER-located peptide transporter for peptide translocation into microsomes
UniProtKB/Swiss-Prot Function:
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

Phenotypes From GWAS Catalog for CANX Gene

Gene Ontology (GO) - Molecular Function for CANX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16361248
GO:0030246 carbohydrate binding IEA --
GO:0034185 apolipoprotein binding IEA --
genes like me logo Genes that share ontologies with CANX: view
genes like me logo Genes that share phenotypes with CANX: view

Animal Models for CANX Gene

MGI Knock Outs for CANX:

Animal Model Products

miRNA for CANX Gene

miRTarBase miRNAs that target CANX

Clone Products

  • Addgene plasmids for CANX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CANX Gene

Localization for CANX Gene

Subcellular locations from UniProtKB/Swiss-Prot for CANX Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232). {ECO:0000269 PubMed:12643545, ECO:0000269 PubMed:17081065, ECO:0000269 PubMed:22314232}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CANX gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 2
mitochondrion 2
cytosol 2
lysosome 2
golgi apparatus 2
endosome 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CANX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA,IEA 14966132
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IDA 19723497
GO:0005790 smooth endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with CANX: view

Pathways & Interactions for CANX Gene

genes like me logo Genes that share pathways with CANX: view

Gene Ontology (GO) - Biological Process for CANX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006457 protein folding IEA,TAS --
GO:0007568 aging IEA --
GO:0009306 protein secretion TAS 8055875
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with CANX: view

No data available for SIGNOR curated interactions for CANX Gene

Drugs & Compounds for CANX Gene

(23) Drugs for CANX Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Antihemophilic factor, human recombinant Approved, Investigational Pharma Target, chaperone 0
Calcium Citrate Approved Pharma Target, ligand 0
Calcium Phosphate Approved Pharma Target, ligand 0
Tenecteplase Approved Pharma Target 42

(17) Additional Compounds for CANX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CANX: view

Transcripts for CANX Gene

Unigene Clusters for CANX Gene

Calnexin:
Representative Sequences:

Clone Products

  • Addgene plasmids for CANX

Alternative Splicing Database (ASD) splice patterns (SP) for CANX Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - -
SP6:
SP7: - - -
SP8: -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CANX Gene

GeneLoc Exon Structure for
CANX
ECgene alternative splicing isoforms for
CANX

Expression for CANX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CANX Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CANX Gene



Protein tissue co-expression partners for CANX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CANX Gene:

CANX

SOURCE GeneReport for Unigene cluster for CANX Gene:

Hs.567968

Evidence on tissue expression from TISSUES for CANX Gene

  • Nervous system(5)
  • Liver(4.9)
  • Skin(4.8)
  • Blood(4.6)
  • Lung(4.2)
  • Intestine(4)
  • Kidney(4)
  • Pancreas(3.5)
  • Stomach(3.4)
  • Eye(3.3)
  • Heart(3.3)
  • Thyroid gland(2.9)
  • Muscle(2.8)
  • Spleen(2.8)
  • Adrenal gland(2.5)
  • Bone(2.5)
  • Lymph node(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with CANX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CANX Gene

Orthologs for CANX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CANX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CANX 33 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia CANX 33 34
  • 91.6 (n)
cow
(Bos Taurus)
Mammalia CANX 33 34
  • 90.69 (n)
rat
(Rattus norvegicus)
Mammalia Canx 33
  • 89.47 (n)
mouse
(Mus musculus)
Mammalia Canx 33 16 34
  • 88.31 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 87 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CANX 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves CANX 33 34
  • 79.44 (n)
lizard
(Anolis carolinensis)
Reptilia CANX 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia canx 33
  • 73.42 (n)
zebrafish
(Danio rerio)
Actinopterygii canx 33 34
  • 69.78 (n)
wufc27b06 33
fruit fly
(Drosophila melanogaster)
Insecta Cnx99A 35 34
  • 61 (a)
Cnx14D 33 34
  • 57.23 (n)
CG1924 35 34
  • 49 (a)
CG9906 35
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005032 33
  • 57.81 (n)
worm
(Caenorhabditis elegans)
Secernentea cnx-1 35 33 34
  • 55.9 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNE1 34 36
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CNX1 33
  • 58.25 (n)
soybean
(Glycine max)
eudicotyledons Gma.6427 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2586 33
rice
(Oryza sativa)
Liliopsida Os04g0402100 33
  • 57.68 (n)
Os.11092 33
barley
(Hordeum vulgare)
Liliopsida Hv.3581 33
wheat
(Triticum aestivum)
Liliopsida Ta.2538 33
corn
(Zea mays)
Liliopsida Zm.2862 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14852 33
Species where no ortholog for CANX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CANX Gene

ENSEMBL:
Gene Tree for CANX (if available)
TreeFam:
Gene Tree for CANX (if available)

Paralogs for CANX Gene

Paralogs for CANX Gene

genes like me logo Genes that share paralogs with CANX: view

Variants for CANX Gene

Sequence variations from dbSNP and Humsavar for CANX Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000076858 -- 179,715,725(+) T/A intron_variant
rs1000126546 -- 179,709,614(+) C/T intron_variant
rs1000132233 -- 179,680,792(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000146980 -- 179,714,500(+) TTTTTT/TTTT/TTTTT intron_variant
rs1000202930 -- 179,684,941(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CANX Gene

Variant ID Type Subtype PubMed ID
nsv5160 CNV insertion 18451855
nsv830560 CNV loss 17160897

Variation tolerance for CANX Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CANX Gene

Human Gene Mutation Database (HGMD)
CANX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CANX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CANX Gene

Disorders for CANX Gene

MalaCards: The human disease database

(10) MalaCards diseases for CANX Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
orbital melanoma
hyperhidrosis, gustatory
  • hyprg
maxillary sinus squamous cell carcinoma
  • epidermoid carcinoma of the maxillofacial sinus
myeloperoxidase deficiency
  • mpod
lateral medullary syndrome
  • posterior inferior cerebellar artery syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CANX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CANX

genes like me logo Genes that share disorders with CANX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CANX Gene

Publications for CANX Gene

  1. Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. (PMID: 8136357) Tjoelker LW … Gray PW (Biochemistry 1994) 2 3 4 22 58
  2. The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. (PMID: 1326756) Galvin K … Ozturk M (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 22 58
  3. The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin. (PMID: 8055875) Honoré B … Celis JE (Electrophoresis 1994) 3 4 22 58
  4. SERPINA2 is a novel gene with a divergent function from SERPINA1. (PMID: 23826168) Marques PI … Seixas S (PloS one 2013) 3 4 58
  5. Palmitoylated calnexin is a key component of the ribosome-translocon complex. (PMID: 22314232) Lakkaraju AK … van der Goot FG (The EMBO journal 2012) 3 4 58

Products for CANX Gene

  • Addgene plasmids for CANX

Sources for CANX Gene