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Aliases for CAB39L Gene

Aliases for CAB39L Gene

  • Calcium Binding Protein 39 Like 2 3 5
  • Mo25-Like Protein 3 4
  • Antigen MLAA-34 3 4
  • MO25beta 3 4
  • Calcium-Binding Protein 39-Like 3
  • Calcium Binding Protein 39-Like 2
  • Sarcoma Antigen NY-SAR-79 3
  • U937-Associated Antigen 3
  • BA103J18.3 3
  • MO25-BETA 3
  • MO2L 3

External Ids for CAB39L Gene

Previous GeneCards Identifiers for CAB39L Gene

  • GC13M047682
  • GC13M048781
  • GC13M049882
  • GC13M030678

Summaries for CAB39L Gene

GeneCards Summary for CAB39L Gene

CAB39L (Calcium Binding Protein 39 Like) is a Protein Coding gene. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and RET signaling. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is CAB39.

UniProtKB/Swiss-Prot for CAB39L Gene

  • Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).

Gene Wiki entry for CAB39L Gene

Additional gene information for CAB39L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAB39L Gene

Genomics for CAB39L Gene

GeneHancer (GH) Regulatory Elements for CAB39L Gene

Promoters and enhancers for CAB39L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J049442 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 661.6 -1.5 -1492 5.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SETDB2 CAB39L PHF11 ARL11 EBPL SNRPGP14 GC13P049390
GH13J049400 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 654.8 +42.6 42601 1.2 HDAC1 ZBTB40 CTBP1 GATA3 NCOR1 POLR2A CREM CBFA2T3 NCOA1 REST CAB39L PHF11 MLNR GC13P049413 GC13P049390
GH13J049247 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8.8 +195.9 195852 2.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 LOC105370203 CDADC1 SETDB2 TRIM13 KCNRG CAB39L GC13M049249 GC13M049248
GH13J049313 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +129.7 129720 2.1 FOXA2 MLX ARID4B SIN3A DMAP1 ETS1 SLC30A9 FOS SP5 ZNF518A CAB39L GC13P049296 GC13P049390
GH13J049307 Enhancer 1.1 Ensembl ENCODE dbSUPER 8.1 +135.8 135792 2.3 SOX13 FOXA2 ARID4B RAD21 YY1 NR2F6 GATAD2A SOX5 RXRA FOXA3 CAB39L GC13P049296 GC13P049390
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAB39L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAB39L gene promoter:
  • C/EBPalpha
  • MEF-2A
  • aMEF-2
  • FOXD1
  • HNF-1
  • E4BP4
  • HNF-1A
  • POU2F1
  • POU2F1a
  • POU2F1b

Genomic Locations for CAB39L Gene

Genomic Locations for CAB39L Gene
135,488 bases
Minus strand
135,477 bases
Minus strand

Genomic View for CAB39L Gene

Genes around CAB39L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAB39L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAB39L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAB39L Gene

Proteins for CAB39L Gene

  • Protein details for CAB39L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-binding protein 39-like
    Protein Accession:
    Secondary Accessions:
    • Q5TAW6
    • Q6WG71
    • Q96FG1
    • Q9BZ33

    Protein attributes for CAB39L Gene

    337 amino acids
    Molecular mass:
    39088 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.
    • Found in serum of 50% of patients with acute monocytic leukemia.
    • Sequence=BAB14147.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAB39L Gene

neXtProt entry for CAB39L Gene

Post-translational modifications for CAB39L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for CAB39L
  • Boster Bio Antibodies for CAB39L
  • Santa Cruz Biotechnology (SCBT) Antibodies for CAB39L

No data available for DME Specific Peptides for CAB39L Gene

Domains & Families for CAB39L Gene

Gene Families for CAB39L Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAB39L Gene


Suggested Antigen Peptide Sequences for CAB39L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Mo25 family.
  • Belongs to the Mo25 family.
genes like me logo Genes that share domains with CAB39L: view

Function for CAB39L Gene

Molecular function for CAB39L Gene

UniProtKB/Swiss-Prot Function:
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).

Phenotypes From GWAS Catalog for CAB39L Gene

Gene Ontology (GO) - Molecular Function for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CAB39L: view
genes like me logo Genes that share phenotypes with CAB39L: view

Animal Models for CAB39L Gene

MGI Knock Outs for CAB39L:
  • Cab39l Cab39l<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAB39L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAB39L Gene

Localization for CAB39L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAB39L gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with CAB39L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAB39L Gene

Pathways & Interactions for CAB39L Gene

genes like me logo Genes that share pathways with CAB39L: view

Pathways by source for CAB39L Gene

Gene Ontology (GO) - Biological Process for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
genes like me logo Genes that share ontologies with CAB39L: view

No data available for SIGNOR curated interactions for CAB39L Gene

Drugs & Compounds for CAB39L Gene

No Compound Related Data Available

Transcripts for CAB39L Gene

Unigene Clusters for CAB39L Gene

Calcium binding protein 39-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAB39L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAB39L Gene

No ASD Table

Relevant External Links for CAB39L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAB39L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAB39L Gene

Protein differential expression in normal tissues from HIPED for CAB39L Gene

This gene is overexpressed in Cardia (17.3) and Colon muscle (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAB39L Gene

Protein tissue co-expression partners for CAB39L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAB39L Gene:


SOURCE GeneReport for Unigene cluster for CAB39L Gene:

genes like me logo Genes that share expression patterns with CAB39L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAB39L Gene

Orthologs for CAB39L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAB39L 34 33
  • 99.8 (n)
(Monodelphis domestica)
Mammalia CAB39L 34
  • 96 (a)
(Bos Taurus)
Mammalia CAB39L 34 33
  • 91.02 (n)
(Canis familiaris)
Mammalia CAB39L 34 33
  • 90.6 (n)
(Mus musculus)
Mammalia Cab39l 16 34 33
  • 90.5 (n)
(Rattus norvegicus)
Mammalia Cab39l 33
  • 89.91 (n)
(Ornithorhynchus anatinus)
Mammalia CAB39L 34
  • 63 (a)
(Gallus gallus)
Aves CAB39L 34 33
  • 83.99 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cab39l 33
  • 78.44 (n)
Str.15219 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68674 33
(Danio rerio)
Actinopterygii cab39l 34 33
  • 74.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mo25 34
  • 64 (a)
(Caenorhabditis elegans)
Secernentea mop-25.2 34
  • 56 (a)
mop-25.1 34
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYM1 34
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18940 33
  • 52.54 (n)
(Oryza sativa)
Liliopsida Os03g0359700 33
  • 51.04 (n)
(Zea mays)
Liliopsida Zm.3116 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3108 34
  • 63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pmo25 33
  • 54.26 (n)
Species where no ortholog for CAB39L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAB39L Gene

Gene Tree for CAB39L (if available)
Gene Tree for CAB39L (if available)
Evolutionary constrained regions (ECRs) for CAB39L: view image

Paralogs for CAB39L Gene

Paralogs for CAB39L Gene

(2) SIMAP similar genes for CAB39L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CAB39L: view

Variants for CAB39L Gene

Sequence variations from dbSNP and Humsavar for CAB39L Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000039244 -- 49,394,904(-) G/A intron_variant
rs1000085002 -- 49,407,529(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000095124 -- 49,324,306(-) G/A intron_variant
rs1000117272 -- 49,339,063(-) G/A intron_variant
rs1000137740 -- 49,412,166(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAB39L Gene

Variant ID Type Subtype PubMed ID
dgv969n106 CNV deletion 24896259
esv1939259 CNV deletion 18987734
esv2273400 CNV deletion 18987734
esv2539030 CNV deletion 19546169
esv2675887 CNV deletion 23128226
esv2747391 CNV deletion 23290073
esv2747392 CNV deletion 23290073
esv2747393 CNV deletion 23290073
esv3304012 CNV mobile element insertion 20981092
esv3339499 CNV insertion 20981092
esv3377952 CNV insertion 20981092
esv3404428 CNV insertion 20981092
esv3449183 CNV duplication 20981092
esv3550444 CNV deletion 23714750
esv3580632 CNV loss 25503493
esv3632044 CNV loss 21293372
esv3632046 CNV loss 21293372
esv4504 CNV loss 18987735
esv989296 CNV deletion 20482838
esv997002 CNV deletion 20482838
nsv1037 CNV deletion 18451855
nsv1069752 CNV deletion 25765185
nsv1149895 CNV deletion 26484159
nsv435647 CNV deletion 17901297
nsv512316 CNV loss 21212237
nsv523648 CNV gain 19592680
nsv561613 CNV loss 21841781
nsv64662 CNV deletion 16902084
nsv832607 CNV loss 17160897
nsv957462 CNV deletion 24416366

Variation tolerance for CAB39L Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAB39L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAB39L Gene

Disorders for CAB39L Gene

Additional Disease Information for CAB39L

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CAB39L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAB39L Gene

Publications for CAB39L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34. (PMID: 18592235) Zhang PY … Li WB (Cancer immunology, immunotherapy : CII 2009) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CAB39L Gene

Sources for CAB39L Gene

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