Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NDEL1 Gene

Aliases for NDEL1 Gene

  • NudE Neurodevelopment Protein 1 Like 1 2 3 5
  • Mitosin-Associated Protein 1 3 4
  • Protein Nudel 3 4
  • MITAP1 3 4
  • NUDEL 3 4
  • EOPA 3 4
  • NudE Nuclear Distribution Gene E Homolog (A. Nidulans)-Like 1 2
  • NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 2
  • NudE Nuclear Distribution Gene E Homolog-Like 1 3
  • NudE Nuclear Distribution E Homolog-Like 1 3
  • Nuclear Distribution Protein NudE-Like 1 3
  • Mitosin-Associated Protein MITAP1 3
  • Endooligopeptidase A 3
  • NDE1L1 3
  • NDE2 3

External Ids for NDEL1 Gene

Previous GeneCards Identifiers for NDEL1 Gene

  • GC17P008282
  • GC17P008539
  • GC17P008279

Summaries for NDEL1 Gene

Entrez Gene Summary for NDEL1 Gene

  • This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]

GeneCards Summary for NDEL1 Gene

NDEL1 (NudE Neurodevelopment Protein 1 Like 1) is a Protein Coding gene. Diseases associated with NDEL1 include Congenital Nervous System Abnormality and Miller-Dieker Lissencephaly Syndrome. Among its related pathways are Cell Cycle, Mitotic and Reelin Pathway (Cajal-Retzius cells). Gene Ontology (GO) annotations related to this gene include beta-tubulin binding. An important paralog of this gene is NDE1.

UniProtKB/Swiss-Prot for NDEL1 Gene

  • Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).

Gene Wiki entry for NDEL1 Gene

Additional gene information for NDEL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDEL1 Gene

Genomics for NDEL1 Gene

GeneHancer (GH) Regulatory Elements for NDEL1 Gene

Promoters and enhancers for NDEL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J008435 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655.6 +23.4 23376 2.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NDEL1 RPL26 KRBA2 RNF222 RNU7-43P ENSG00000212206 MYH10 GC17P008467
GH17J008412 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 660.1 -0.1 -149 1.6 HDAC1 KLF1 ATF1 ZNF473 ZBTB21 JUN CEBPG RAD21 HIC1 FOSL1 NDEL1 WRAP53 RPL26 KRBA2 ZBTB4 SLC25A35 RANGRF PFAS PIK3R6 CNTROB
GH17J008414 Enhancer 0.3 Ensembl 650.7 +1.2 1170 0.2 ZNF146 NDEL1 RPL26 KRBA2 SLC25A35 RANGRF PFAS GC17P008467
GH17J008415 Enhancer 0.2 Ensembl 655.9 +1.7 1670 0.4 NDEL1 RPL26 KRBA2 SLC25A35 RANGRF PFAS RNF222 GC17P008467
GH17J008149 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.8 -255.8 -255812 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 PER1 VAMP2 DVL2 CTC1 PFAS CNTROB POLR2A ENSG00000265749 WRAP53 SNORD10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NDEL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDEL1 gene promoter:
  • ARP-1
  • RFX1
  • Hlf
  • Olf-1
  • p53
  • Egr-2
  • c-Myc
  • Max
  • POU3F2 (N-Oct-5b)

Genomic Locations for NDEL1 Gene

Genomic Locations for NDEL1 Gene
chr17:8,413,131-8,490,411
(GRCh38/hg38)
Size:
77,281 bases
Orientation:
Plus strand
chr17:8,316,449-8,393,729
(GRCh37/hg19)
Size:
77,281 bases
Orientation:
Plus strand

Genomic View for NDEL1 Gene

Genes around NDEL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDEL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDEL1 Gene

Proteins for NDEL1 Gene

  • Protein details for NDEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZM8-NDEL1_HUMAN
    Recommended name:
    Nuclear distribution protein nudE-like 1
    Protein Accession:
    Q9GZM8
    Secondary Accessions:
    • B3KP93
    • D3DTS0
    • J3QT32
    • Q86T80
    • Q8TAR7
    • Q9UH50

    Protein attributes for NDEL1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38375 Da
    Quaternary structure:
    • Interacts with PLEKHM1 (via N- and C-terminus) (By similarity). Interacts with YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts with microtubules (By similarity). Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1, PAFAH1B1, PCM1 and PCNT. Interacts (via C-terminus) with CENPF. Interacts with ZNF365.

    Three dimensional structures from OCA and Proteopedia for NDEL1 Gene

    Alternative splice isoforms for NDEL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDEL1 Gene

Post-translational modifications for NDEL1 Gene

  • Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.
  • Palmitoylation at Cys-273 reduces affinity for dynein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDEL1 Gene

Domains & Families for NDEL1 Gene

Gene Families for NDEL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NDEL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDEL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZM8

UniProtKB/Swiss-Prot:

NDEL1_HUMAN :
  • Belongs to the nudE family.
Family:
  • Belongs to the nudE family.
genes like me logo Genes that share domains with NDEL1: view

Function for NDEL1 Gene

Molecular function for NDEL1 Gene

UniProtKB/Swiss-Prot Function:
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).

Gene Ontology (GO) - Molecular Function for NDEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10931877
GO:0008017 microtubule binding IBA --
GO:0042802 identical protein binding IPI 10931877
GO:0043014 alpha-tubulin binding IEA --
GO:0048487 beta-tubulin binding IEA --
genes like me logo Genes that share ontologies with NDEL1: view
genes like me logo Genes that share phenotypes with NDEL1: view

Animal Models for NDEL1 Gene

MGI Knock Outs for NDEL1:

Animal Model Products

Clone Products

  • Addgene plasmids for NDEL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDEL1 Gene

Localization for NDEL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDEL1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDEL1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for NDEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA,IDA 17600710
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005635 nuclear envelope IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with NDEL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NDEL1 Gene

Pathways & Interactions for NDEL1 Gene

genes like me logo Genes that share pathways with NDEL1: view

Pathways by source for NDEL1 Gene

Gene Ontology (GO) - Biological Process for NDEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IBA --
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0001764 neuron migration IEA --
GO:0001833 inner cell mass cell proliferation IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with NDEL1: view

No data available for SIGNOR curated interactions for NDEL1 Gene

Drugs & Compounds for NDEL1 Gene

No Compound Related Data Available

Transcripts for NDEL1 Gene

Unigene Clusters for NDEL1 Gene

NudE nuclear distribution E homolog (A. nidulans)-like 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for NDEL1

Alternative Splicing Database (ASD) splice patterns (SP) for NDEL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - - -
SP7:
SP8: - - - -
SP9:
SP10: -

Relevant External Links for NDEL1 Gene

GeneLoc Exon Structure for
NDEL1
ECgene alternative splicing isoforms for
NDEL1

Expression for NDEL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDEL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDEL1 Gene

This gene is overexpressed in Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for NDEL1 Gene

This gene is overexpressed in Fetal Brain (42.0), Fetal heart (10.1), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NDEL1 Gene



Protein tissue co-expression partners for NDEL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NDEL1 Gene:

NDEL1

SOURCE GeneReport for Unigene cluster for NDEL1 Gene:

Hs.372123

mRNA Expression by UniProt/SwissProt for NDEL1 Gene:

Q9GZM8-NDEL1_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Evidence on tissue expression from TISSUES for NDEL1 Gene

  • Nervous system(4.9)
  • Adrenal gland(2)
  • Blood(2)
genes like me logo Genes that share expression patterns with NDEL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NDEL1 Gene

Orthologs for NDEL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDEL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDEL1 34 33
  • 99.89 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDEL1 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDEL1 34 33
  • 95.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NDEL1 34 33
  • 93.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndel1 33
  • 92.08 (n)
mouse
(Mus musculus)
Mammalia Ndel1 16 34 33
  • 91.3 (n)
chicken
(Gallus gallus)
Aves NDEL1 34 33
  • 82.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDEL1 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndel1 33
  • 70.09 (n)
zebrafish
(Danio rerio)
Actinopterygii ndel1a 34
  • 72 (a)
OneToMany
ndel1b 34 33
  • 68.12 (n)
OneToMany
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3827 33
fruit fly
(Drosophila melanogaster)
Insecta nudE 34 33
  • 47.46 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009914 33
  • 44.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8970 34
  • 42 (a)
OneToMany
Cin.1886 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1886 33
Species where no ortholog for NDEL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDEL1 Gene

ENSEMBL:
Gene Tree for NDEL1 (if available)
TreeFam:
Gene Tree for NDEL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NDEL1: view image

Paralogs for NDEL1 Gene

Paralogs for NDEL1 Gene

(1) SIMAP similar genes for NDEL1 Gene using alignment to 11 proteins:

  • NDEL1_HUMAN
  • A6NIZ0_HUMAN
  • J3KRK9_HUMAN
  • J3KSF2_HUMAN
  • J3KT16_HUMAN
  • J3QL31_HUMAN
  • J3QL85_HUMAN
  • J3QLD0_HUMAN
  • J3QRD2_HUMAN
  • J3QRZ1_HUMAN
  • J3QSD2_HUMAN

Pseudogenes.org Pseudogenes for NDEL1 Gene

genes like me logo Genes that share paralogs with NDEL1: view

Variants for NDEL1 Gene

Sequence variations from dbSNP and Humsavar for NDEL1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000031279 -- 8,446,977(+) C/T intron_variant
rs1000045214 -- 8,438,666(+) C/T intron_variant
rs1000052084 -- 8,456,825(+) G/T intron_variant
rs1000144947 -- 8,439,182(+) C/T intron_variant
rs1000211748 -- 8,452,437(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NDEL1 Gene

Variant ID Type Subtype PubMed ID
nsv112058 CNV deletion 16902084
nsv509651 CNV insertion 20534489

Variation tolerance for NDEL1 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDEL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDEL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDEL1 Gene

Disorders for NDEL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NDEL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital nervous system abnormality
  • congenital neurologic anomaly
miller-dieker lissencephaly syndrome
  • mdls
- elite association - COSMIC cancer census association via MalaCards
Search NDEL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NDEL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NDEL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDEL1 Gene

Publications for NDEL1 Gene

  1. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. (PMID: 11163260) Niethammer M … Tsai LH (Neuron 2000) 2 3 4 22 58
  2. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. (PMID: 17035248) Kamiya A … Sawa A (Human molecular genetics 2006) 3 4 22 58
  3. Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1. (PMID: 15728732) Hayashi MA … Camargo AC (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 58
  4. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. (PMID: 16203747) Toyo-Oka K … Hirotsune S (Human molecular genetics 2005) 3 4 22 58
  5. Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. (PMID: 12556484) Yan X … Zhu X (Molecular and cellular biology 2003) 3 4 22 58

Products for NDEL1 Gene

Sources for NDEL1 Gene

Content
Loading form....